Translocations et al. in Hematological Cancers

Acknowledgement

This list is based on the Mayo Clinic Hematologic Cytogenetics Reference Sheet, November 2012.

Translocations Long List

Translocations
ANOMALY ASSOCIATED DISORDERS with FISH test GENES
der(1)t(1;1)(p36;q21) NHL
t(1;3)(p36;q21) MDS,AML PRDM16(MEL1)-RPN1
t(1;3;5)(p36;p21;q33) CEL WDR48-PDGFRB
t(1;5)(q21;q33) MPD TPM3-PDGFRB 
t(1;5)(q22;q33) MPD,CEL,B-ALL PDE4DIP-PDGFRB
der(1;7)(q10;p10) MDS,AML,MPD
t(1;8)(p13;q24.1) MYC
t(1;14)(q21;q32) B-ALL,NHL IGH-BCL9,IGH-FCGR2B,IGH-FCRL4,IGH-MUC1
t(1;19)(q23;p13.3) B-ALL TCF3(E2A)-PBX1
der(16)t(1;16)(q21;q11.2)
der(1;22)(q10;p10)
t(2;5)(p23;q35) ALCL,NHL NPM1-ALK
t(2;8)(p12;q24.1) BL,B-ALL,NHL MYC
t(2;11)(p21;q23) MDS,AML,B-ALL KMT2A
t(2;14)(p15;q32) CLL,NHL,B-ALL,T-ALL,AML
t(3;3)(q21;q26.2) MDS,AML RPN1-MECOM(EVI1)
t(3;5)(p21-25;q32-35) MPD GOLGA4-PDGFRB
t(3;21)(q26.2;q22) t-AML,t-MDS RPL22(EAP)-RUNX1(AML1)
t(4;11)(q21;q23) B-ALL,T-ALL KMT2A-AFF1
t(4;14)(p16.3;q32) MM IGH-FGFR3
t(4;22)(q12;q11) atypical MPD BCR-PDGFRA
t(4;5;5)(q23;q31;q33) Chronic Basophilic Leukemia PRKG2-PDGFRB
t(5;7)(q33;q11.2) CMML HIP1-PDGFRB
t(5;10)(q33;q21) atypical MPD CCD6-PDGFRB
t(5;12)(q31;p13) CEL,MPD ETV6(TEL)-ACSL6
t(5;12)(q33;q24) MPD GIT2-PDGFRB
t(5;12)(q33;p13) CMML,MDS,MPD ETV6(TEL)-PDGFRB
t(5;14)(q33;q24) MPD,MPD NIN-PDGFRB
t(5;14)(q33;q32) CCDC88C(KIAA1509)-PDGFRB
t(5;15)(q33;q22) CMML,MPD TP53BP1-PDGFRB
t(5;14)(q35;q32) T-cell lymphoma TLX3(HOX11L2)-BCL11B
t(5;16)(q33;q22) AML CBFB
der(5;17)(p10;q10) MDS,AML NPM1(NPM)-RARA
t(5;17)(q33;p11.2) JMML SPECC1-PDGFRB
t(5;17)(q33;p13) CMML,MPD RABEP1-PDGFRB 
der(6)t(1;6)(q21;p21.3) PMF
t(6;9)(p23;q34) MDS,AML DEK-NUP214 (CAN)
t(6;11)(q27;q23) AML,t-AML,T-ALL KMT2A-MLLT4
t(7;11)(p15;p15) AML NUP98-HOXA9
t(8;14)(q24.1;q32) BL,B-ALL,NHL IGH-MYC
t(8;16)(p11.2;p13.3) AML,t-MDS KAT6A(MYST3)-CREBBP(CBP)
t(8;21)(q22;q22) A AML RUNX1(AML)-RUNX1T1(ETO)
t(8;22)(q24.1;q11.2) BL,B-ALL,NHL,MM IGL-MYC
add(9)(p24) JAK2
t(9;11)(p22;q23) AML,B-ALL KMT2A-MLLT3
t(9;14)(p13;q32) MM,CLL,DLBCL,FL,MCL splenic MZL PAX5-IGH
t(9;22)(q34;q11.2) CML,B-ALL,T-ALL ABL1(ABL)-BCR
t(11;14)(q13;q32) MCL,MM IGH-CCND1
t(11;14)(q23;q32) AML KMT2A-KIAA0284
t(11;16)(q23;p13.3) t-MDS,t-AML MLL-CREBBP(CBP)
t(11;17)(q23;q21) APL ZBTB16(PLZF)-RARA
t(11;18)(q21;q21) MALT BIRC3(API2)-MALT1
t(11;19)(q23;p13.1) AML KMT2A-ELL
t(11;19)(q23;p13.3) B-ALL,AML,T-ALL KMT2A-MLLT1
t(14;16)(q32;q23) MM IGH-MAF
t(14;18)(q32;q21) BL,DLBCL,FL,CLL IGH-BCL2
t(14;19)(q32;q13.3) CLL,DLBCL,MCL,MZL,SLVL IGH-BCL3
t(14;19)(q32;q13) B-ALL IGH-EPOR
t(14;22)(q32;q11.2) B-ALL,CLL,HCL,AML,NHL,DLBCL IGH-IGL
t(15;17)(q24;q21) APL PML-RARA
t(16;16)(p13.1;q22) AML M4Eo MYH11-CBFB
der(19)t(1;19)(q23;p13.3) B-ALL,L3-like ALL,T-ALL,NHL,AML PBX1-TCF3(E2A)
der(Y)t(Y;1)(q12;q12) MDS

Inversions

INVERSIONS
ANOMALY ASSOCIATED DISORDERS with FISH test GENES
inv(3)(q21q26.2) MDS,AML RPN1-MECOM(EVI1)
inv(11)(q21q23) MDS,AML M2,T-ALL MAML2-MLL
inv(14)(q11.2q32) PLL TRA-TCL1A(TCL1)
inv(16)(p13.1q22) AML M4Eo MYH11-CBFB

Duplications

DUPLICATIONS
ANOMALY ASSOCIATED DISORDERS with FISH test GENES
dup(1)(q11q44)
dup(1)(q21q32) B-ALL,NHL
dup(1)(q21q42)
dup(1)(q23q32)
dup(1)(q23q42) NHL
dup(11)(q13q25) NHL MLL
dup(12)(q13q22)

Isochromsomes

ISOCHROMOSOMES
ANOMALY ASSOCIATED DISORDERS with FISH test GENES
i(1)(q10) NHL
i(3)(q10) NHL
i(7)(q10) T-cell lymphoma
i(8)(q10) T-ALL,AML,B-ALL
i(11)(q10) AML M2,AML M4,MDS
i(17)(q10) MDS,MPD,AML,CML,B-ALL,CLL,Hodgkin and NHL
i(21)(q10) B-ALL,MDS,NHL,AML,CMML
idic(X)(q13) AML M1,M2,M4,MDS,RARS XIST

Cryptic

CRYPTIC
ANOMALY ASSOCIATED DISORDERS with FISH test GENES
t(12;21)(p13;q22) B-ALL ETV6 (TEL)-RUNX1(AML1)
t(X;14) and t(Y;14) B-ALL IGH-CRLF2
t(5;14)(q35;q32) T-ALL TLX3-BCL11B
del(1)(p32p32) T-ALL SIL(STIL)-TAL1

Deletions

DELETIONS
ANOMALY ASSOCIATED DISORDERS with FISH test GENES
del(1)(p32p36) NHL,MM
del(1)(p32-34p36.1)
del(1)(p36.1) Neuroblastoma TP73(P73)
del(3)(p13p21)
del(3)(q21) B-ALL,AML,NHL
del(5)(q13q33) AML,MDS,MPD  PDGFRB
del(5)(q15q33) AML,MDS,MPD  PDGFRB 
del(5)(q22q35) AML,MDS,MPD  PDGFRB 
del(5)(q31q35) AML,MDS,MPD  PDGFRB 
del(6)(q13q21) WM/LPL,MM,NK lymphoma,DLBCL BLMP1-PRDM1
del(6)(q13q23) CLL,atypical CLL,FL,MCL,T-NHL,childhood B-ALL,childhood T-ALL,adult ALL,MM
del(6)(q15q21)
del(6)(q21) CLL,atypical CLL,AML,childhood B-ALL,childhood T-ALL,adult ALL,MM
del(7)(p15)
del(7)(p13) AML,NHL
del(7)(p13p15)
del(7)(p11.2) B-ALL,AML,MDS
del(7)(q11.2) B-ALL,AML,MDS
del(7)(q22q34) AML,MDS,NHL
del(7)(q32q34) AML,MDS,NHL
del(7)(q32) AML,MDS,NHL
del(8)(p21)
del(8)(q22)
del(9)(p13) B-ALL,NHL,pediatric B-ALL
del(9)(p13p22) B-ALL
del(9)(p21) B-ALL,AML,NHL
del(9)(p22) B-ALL
del(9)(q13) AML M1,M2,M4,M6
del(9)(q13q22) AML,MDS
del(10)(q24)
del(11)(p11.2) NHL
del(11)(p12p13) B-ALL LMO2
del(11)(q13)
del(11)(q13q21)
del(11)(q13q23) AML,CLL,MDS,NHL ATM
del(11)(q21q23) AML MLL
del(11)(q23) AML,B-ALL,CLL,MDS,NHL MLL
add(12)(p)/ del(12)(p11.2p13) AML,MDS,B-ALL ETV6(TEL)
del(13)(q12q14) AML,AMM,MDS,NHL
del(13)(q12q22) AML,PMF,CLL,MM,MDS,NHL
del(14)(q24) NHL
del(16)(q22) AML,AML-M4Eo,NHL
del(17)(p11.2) B-ALL,AML,CLL,MDS,NHL TP53(P53)
del(18)(q21) AML,NHL
[[del(20)(q11.2q13.1) del(20)(q11.2q13.3) AML,MDS,MPD
ider(20)(p11.1)del(20)(q11.2q13.3) AML,MDS,MPD
del(X)(q24) NHL

Numerical Abnormalities

NUMERICAL
ANOMALY ASSOCIATED DISORDERS with FISH test
+3 SLVL,T-cell lymphoma,MZL,MCL,MALT
+4 AML M1-M2 and M4,and treatment related AML
+8 B-ALL,AML,MPD,MDS,PV
+9 AML,MDS,MPD,PV,B-ALL,T-ALL
+10 AML,B-ALL,MDS
+11 AML M1,M2,M4,MDS
+12 AML,CLL,NHL,MALT,HCL,SLVL,WM/LPL,FL,MCL and DLBCL
+13/+13,+13 AML-M0
+14 MDS RA,RAEB±T mainly,AML M1,M2,M4,atypical MPD
+15 Age related when sole anomaly or with -Y
+19 AML,MDS
+21 AML,B-ALL,MDS,MPD
+22 AML-M4eo
-7 MDS,RAEB/RAEB±T,CMML,J-CML,AML most often M4 or M6.
-Y age related when sole anomaly

Primarily Pediatric

PEDIATRIC
ANOMALY ASSOCIATED DISORDERS with FISH test GENES
t(1;19)(q23;p13.3) B-ALL PBX1-TCF3(E2A)
der(19)t(1;19)(q23;p13.3) B-ALL PBX1-TCF3(E2A)
t(8;14)(q11;q32) B-ALL IGH-CEBPB
i(9)(q10)/idic(9)(q10) B-ALL
dic(9;12)(p11;p11.2) B-ALL
dic(9;20)(p11;q11) B-ALL PAX5
t(17;19)(q22;p13) B-ALL TCF3(E2A)-HLF
t(1;22)(p13;q13) AML M7 RBM15-MKL1
t(10;11)(p13;q23) Primarily AML ,uncommonly B-ALL MLLT10(AF10)/MLL
t(16;21)(p11.2;q22) AML FUS-ERG
t(16;21)(q24;q22) AML CBFA2T3-RUNX1-(AML1)
t(10;11)(p13;q14) T-ALL MLLT10(AF10)/PICALM 
t(11;14)(p15;q11.2) T-ALL LMO1-TRA
t(11;14)(p13;q11-q11.2) T-ALL LMO2(Rhom2)-TRA