| Gene Symbol |
Chromosome Band |
Tumour Types |
Translocation Partner (if any)
|
| SEPT5 |
22q11.21 |
AML |
KMT2A
|
| SEPT6 |
Xq24 |
AML |
KMT2A
|
| SEPT9 |
17q25 |
AML |
KMT2A
|
| ABI1 |
10p11.2 |
AML |
KMT2A
|
| ABL1 |
9q34.1 |
CML,ALL,T-ALL |
BCR,ETV6,NUP214
|
| ABL2 |
1q24-q25 |
AML |
ETV6
|
| ACKR3 |
2q37.3 |
lipoma |
HMGA2
|
| ACSL3 |
2q36 |
prostate |
ETV1
|
| ACSL6 |
5q31.1 |
AML,AEL |
ETV6
|
| ACVR1 |
2q23-q24 |
DIPG |
|
| AFF1 |
4q21 |
AL |
KMT2A
|
| AFF3 |
2q11.2-q12 |
ALL,T-ALL |
KMT2A,RUNX1
|
| AFF4 |
5q31 |
ALL |
KMT2A
|
| AKAP9 |
7q21-q22 |
papillary thyroid |
BRAF
|
| AKT1 |
14q32.32 |
breast,colorectal,ovarian,NSCLC |
|
| AKT2 |
19q13.1-q13.2 |
ovarian,pancreatic |
|
| ALDH2 |
12q24.2 |
leiomyoma |
HMGA2
|
| ALK |
2p23 |
ALCL,NSCLC,neuroblastoma,inflammatory myofibroblastic tumour,Spitzoid tumour |
NPM1,TPM3,TFG,TPM4,ATIC,CLTC,MSN,RNF213,CARS,EML4,KIF5B,C2orf22,DCTN1,HIP1,TPR,RANBP2,PPFIBP1,SEC31A,STRN,VCL,C2orf44,KLC1
|
| AMER1 |
Xq11.2 |
Wilms tumour |
|
| APC |
5q21 |
colorectal,pancreatic,desmoid,hepatoblastoma,glioma,other CNS |
|
| ARHGAP26 |
5q31 |
AML,MDS |
KMT2A
|
| ARHGEF12 |
11q23.3 |
AML |
KMT2A
|
| ARID1A |
1p35.3 |
clear cell ovarian carcinoma,RCC,breast |
MAST2
|
| ARID1B |
6q25.1 |
breast,hepatocellular carcinoma |
|
| ARID2 |
12q12 |
hepatocellular carcinoma |
|
| ARNT |
1q21 |
AML |
ETV6
|
| ASPSCR1 |
17q25 |
alveolar soft part sarcoma |
TFE3
|
| ASXL1 |
20q11.1 |
MDS,CMML |
|
| ATF1 |
12q13 |
malignant melanoma of soft parts,angiomatoid fibrous histiocytoma |
EWSR1,FUS
|
| ATIC |
2q35 |
ALCL |
ALK
|
| ATM |
11q22.3 |
T-PLL |
|
| ATP1A1 |
1p21 |
adrenal aldosterone producing adenoma |
|
| ATP2B3 |
Xq28 |
adrenal aldosterone producing adenoma |
|
| ATR |
3q23 |
endometrial,gastric |
|
| ATRX |
Xq21.1 |
pancreatic neuroendocrine tumours,paediatric GBM |
|
| AXIN1 |
16p13.3 |
colorectal,endometrial,prostate,hepatocellular carcinoma,hepatoblastoma,sporadic medulloblastoma |
|
| AXIN2 |
17q24.1 |
colorectal carcinoma,stomach carcinoma,hepatocellular carcinoma |
|
| BAP1 |
3p21.31-p21.2 |
uveal melanoma,breast,NSCLC,RCC |
|
| BCL10 |
1p22 |
MALT |
IGH
|
| BCL11A |
2p13 |
B-CLL |
IGH
|
| BCL11B |
14q32.1 |
T-ALL |
TLX3
|
| BCL2 |
18q21.3 |
NHL,CLL |
IGH
|
| BCL3 |
19q13 |
CLL |
IGH
|
| BCL5 |
17q22 |
CLL |
MYC
|
| BCL6 |
3q27 |
NHL,CLL |
IG loci,ZNFN1A1,LCP1,PIM1,TFRC,CIITA,NACA,HSPCB,HSP90AA1,HIST1H4I,IL21R,POU2AF1,RHOH,EIF4A2,SRSF3
|
| BCL7A |
12q24.1 |
BNHL |
MYC
|
| BCL9 |
1q21 |
B-ALL |
IGH,IGL
|
| BCOR |
Xp11.4 |
retinoblastoma,AML,APL (translocation) |
RARA
|
| BCR |
22q11.21 |
CML,ALL,AML |
ABL1,FGFR1,JAK2
|
| BIRC3 |
11q22 |
CLL,MALT,MCL,MM |
MALT1
|
| BRAF |
7q34 |
melanoma,colorectal,papillary thyroid,borderline ovarian,NSCLC,cholangiocarcinoma,pilocytic astrocytoma,Spitzoid tumour,pancreas acinar carcinoma,melanocytic nevus,prostate,gastric |
AKAP9,KIAA1549,CEP88,LSM14A,SND1,FCHSD1,SLC45A3,FAM131B,RNF130,CLCN6,MKRN1,GNAI1,AGTRAP
|
| BRCA1 |
17q21 |
ovarian |
|
| BRCA2 |
13q12 |
breast,ovarian,pancreatic |
|
| BRD3 |
9q34 |
lethal midline carcinoma of young people |
NUTM1
|
| BRD4 |
19p13.1 |
lethal midline carcinoma of young people |
NUTM1
|
| BTG1 |
12q22 |
B-CLL |
MYC
|
| C12orf9 |
12q14.3 |
lipoma |
LPP
|
| C15orf65 |
15q21.3 |
PMBL,Hodgkin lymphoma |
CIITA
|
| C2orf44 |
2p23.3 |
colorectal |
ALK
|
| CACNA1D |
3p14.3 |
adrenal aldosterone producing adenoma |
|
| CALR |
19p13.3-p13.2 |
MPN,MDS |
|
| CAMTA1 |
1p36.31-p36.23 |
epithelioid haemangioendothelioma |
WWTR1
|
| CANT1 |
17q25 |
prostate |
ETV4
|
| CARD11 |
7p22 |
DLBCL |
|
| CARS |
11p15.5 |
ALCL |
ALK
|
| CASC5 |
15q14 |
AML |
KMT2A
|
| CASP8 |
2q33-q34 |
hepatocellular,oral squamous cell,breast |
|
| CBFA2T3 |
16q24 |
AML |
RUNX1
|
| CBFB |
16q22 |
AML |
MYH11
|
| CBL |
11q23.3 |
AML,JMML,MDS |
KMT2A
|
| CBLB |
3q13.11 |
AML |
|
| CBLC |
19q13.2 |
AML |
|
| CCDC6 |
10q21 |
papillary thyroid,CML,NSCLC |
RET,PDGFRB
|
| CCNB1IP1 |
14q11.2 |
leiomyoma |
HMGA2
|
| CCND1 |
11q13 |
CLL,B-ALL,breast |
IGH,FSTL3
|
| CCND2 |
12p13 |
NHL,CLL |
IGL
|
| CCND3 |
6p21 |
MM |
IGH
|
| CCNE1 |
19q12 |
serous ovarian |
|
| CD274 |
9p24 |
PMBL,Hodgkin lymphoma |
CIITA
|
| CD74 |
5q32 |
NSCLC |
ROS1,NRG1
|
| CD79A |
19q13.2 |
DLBCL,WM |
|
| CD79B |
17q23 |
DLBCL,WM |
|
| CDC73 |
1q21-q31 |
parathyroid adenoma |
|
| CDH1 |
16q22.1 |
lobular breast,gastric |
|
| CDH11 |
16q22.1 |
aneurysmal bone cyst |
USP6
|
| CDK12 |
17q12 |
serous ovarian |
|
| CDK6 |
7q21-q22 |
ALL |
MLLT10
|
| CDKN1B |
12p13.1-p12 |
breast,small intestine neuroendocrine tumours |
|
| CDKN2A |
9p21 |
melanoma,multiple other tumour types |
|
| CDKN2A(p14) |
9p21 |
melanoma,multiple other tumour types |
|
| CDKN2C |
1p32 |
glioma,MM |
|
| CDX2 |
13q12.3 |
AML |
ETV6
|
| CEBPA |
19q13.1 |
AML,MDS |
|
| CEP89 |
19q13.11 |
Spitzoid tumour |
BRAF
|
| CHCHD7 |
8q11.2 |
salivary adenoma |
PLAG1
|
| CHIC2 |
4q11-q12 |
AML |
ETV6
|
| CHN1 |
2q31-q32.1 |
extraskeletal myxoid chondrosarcoma |
TAF15
|
| CIC |
19q13.2 |
oligodendroglioma,soft tissue sarcoma |
DUX4L1,FOXO4
|
| CIITA |
16p13 |
PMBL,Hodgkin lymphoma |
C15orf55,CD274,PDCD1LG2,RALGDS,RUNDC2A,RMI2,BCL6
|
| CLIP1 |
12q24.3 |
Spitzoid tumour |
ROS1
|
| CLP1 |
11q12 |
AML |
KMT2A
|
| CLTC |
17q11-qter |
ALCL,renal |
ALK,TFE3
|
| CLTCL1 |
22q11.21 |
ALCL |
Unknown
|
| CNBP |
3q21 |
aneurysmal bone cyst |
USP6
|
| CNOT3 |
19q13.4 |
T-ALL |
|
| CNTRL |
9q33.2 |
MPN,NHL |
FGFR1
|
| COL1A1 |
17q21.31-q22 |
DFSP,aneurysmal bone cyst |
PDGFB,USP6
|
| COL2A1 |
12q13.11 |
chondrosarcoma,enchondroma |
|
| COX6C |
8q22-q23 |
uterine leiomyoma |
HMGA2
|
| CREB1 |
2q34 |
clear cell sarcoma,angiomatoid fibrous histiocytoma |
EWSR1
|
| CREB3L1 |
11p11.2 |
myxofibrosarcoma |
FUS
|
| CREB3L2 |
7q34 |
fibromyxoid sarcoma |
FUS
|
| CREBBP |
16p13.3 |
ALL,AML,DLBCL,B-NHL |
KMT2A,MORF,KAT6A
|
| CRLF2 |
Xp22.3; Yp11.3 |
B-ALL,Downs associated ALL |
P2RY8,IGH
|
| CRTC1 |
19p13.11 |
salivary gland mucoepidermoid |
MAML2
|
| CRTC3 |
15q26.1 |
salivary gland mucoepidermoid |
MAML2
|
| CSF3R |
1p35-p34.4 |
aCML,CNL,leukaemia lymphoma and MDS associated with severe congenital neutropenia,CMML,de novo AML,MDS |
|
| CTNNB1 |
3p22-p21.3 |
colorectal,ovarian,hepatoblastoma,pleomorphic salivary gland adenoma,other tumour types |
PLAG1
|
| CUX1 |
7q22.1 |
endometrial,melanoma,colorectal,AML,MDS,other tumour types |
CLDN7
|
| CYLD |
16q12-q13 |
cylindroma |
|
| DAXX |
6p21.3 |
pancreatic neuroendocrine tumour,paediatric glioblastoma |
|
| DCTN1 |
2p13 |
inflammatory myofibroblastic tumour,Spitzoid tumour |
ALK,ROS1
|
| DDIT3 |
12q13.1-q13.2 |
liposarcoma |
FUS,EWSR1
|
| DDX10 |
11q22-q23 |
AML* |
NUP98
|
| DDX5 |
17q21 |
prostate |
ETV4
|
| DDX6 |
11q23.3 |
B-NHL |
IGH
|
| DEK |
6p23 |
AML |
NUP214
|
| DICER1 |
14q32.13 |
sex cord-stromal tumour,TGCT,embryonal rhabdomyosarcoma,pleuropulmonary blastoma,pituitary blastoma,Wilms tumour,thyroid cancer,other tumour types |
|
| DNM2 |
19p13.2 |
T-ALL |
|
| DNMT3A |
2p23 |
AML |
|
| DUX4L1 |
4q35 |
soft tissue sarcoma |
CIC
|
| EBF1 |
5q34 |
lipoma |
HMGA2
|
| ECT2L |
6q24.1 |
ETP ALL |
|
| EGFR |
7p12.3-p12.1 |
glioma,NSCLC |
|
| EIF3E |
8q22-q23 |
colorectal |
RSPO3
|
| EIF4A2 |
3q27.3 |
NHL |
BCL6
|
| ELF4 |
Xq26 |
AML |
ERG
|
| ELK4 |
1q32 |
prostate |
SLC45A3
|
| ELL |
19p13.1 |
AL |
KMT2A
|
| ELN |
7q11.23 |
B-ALL |
PAX5
|
| EML4 |
2p21 |
NSCLC |
ALK
|
| EP300 |
22q13 |
colorectal,breast,pancreatic,AML,ALL,DLBCL |
KMT2A,KAT6A
|
| EPS15 |
1p32 |
ALL |
KMT2A
|
| ERBB2 |
17q21.1 |
breast,ovarian,other tumour types,NSCLC,gastric |
|
| ERBB3 |
12q13 |
colon,gastric,head and neck,bladder,skin |
|
| ERC1 |
12p13.3 |
papillary thyroid,Spitzoid tumour |
RET,ROS1
|
| ERG |
21q22.3 |
Ewing sarcoma,prostate,AML |
EWSR1,TMPRSS2,ELF4,FUS,HERPUD1,NDRG1
|
| ESR1 |
6q25.1 |
breast |
|
| ETNK1 |
12p12.1 |
aCML,CMML,SM-AHD,HES |
|
| ETV1 |
7p22 |
Ewing sarcoma,prostate |
EWSR1,TMPRSS2,SLC45A3,HMGN2P46,HNRNPA2B1. ACSL3
|
| ETV4 |
17q21 |
Ewing sarcoma,prostate carcinoma |
EWSR1,TMPRSS2,DDX5,KLK2,CANT1
|
| ETV5 |
3q28 |
prostate |
TMPRSS2,SCL45A3
|
| ETV6 |
12p13 |
congenital fibrosarcoma,multiple different leukaemia and lymphoma tumour types including ALL,secretory breast,MDS |
NTRK3,RUNX1,PDGFRB,ABL1,MN1,ABL2,ACSL6,CHIC2,ARNT,JAK2,MECOM,CDX2,RNF217-AS1,MNX1,MDS2,PER1,SYK,TTL,FGFR3,PAX5
|
| EWSR1 |
22q12 |
Ewing sarcoma,desmoplastic small round cell tumour ,ALL,clear cell sarcoma,sarcoma,myoepithelioma,mesothelioma |
FLI1,ERG,NR4A3,FEV,ATF1,ETV1,ETV4,WT1,ZNF384,CREB1,POU5F1,PBX1,NFATC1,NFATC2,DDIT3,PATZ1,SMARCA5,SP3,ZNF444,YY1
|
| EZH2 |
7q35-q36 |
DLBCL |
|
| EZR |
6q25.3 |
NSCLC |
ROS1
|
| FAM131B |
7q34 |
pilocytic astrocytoma |
BRAF
|
| FAM46C |
1p12 |
MM |
|
| FAS |
10q24.1 |
TGCT,nasal NK/T lymphoma,skin squamous cell carcinoma-burn scar related |
|
| FBXO11 |
2p16.3 |
DLBCL |
|
| FBXW7 |
4q31.3 |
colorectal,endometrial,T-ALL |
|
| FCGR2B |
1q23 |
ALL |
Unknown
|
| FCRL4 |
1q21 |
B-NHL |
IGH
|
| FEV |
2q36 |
Ewing sarcoma |
EWSR1,FUS
|
| FGFR1 |
8p11.2-p11.1 |
MPN,NHL,salivary adenoma |
BCR,FOP,ZMYM2,CNTRL,PLAG1
|
| FGFR1OP |
6q27 |
MPN,NHL |
FGFR1
|
| FGFR2 |
10q26 |
gastric,NSCLC,endometrial |
|
| FGFR3 |
4p16.3 |
bladder,MM,T-cell lymphoma |
IGH,ETV6
|
| FGFR4 |
5q35.2 |
rhabdomyosarcoma |
|
| FHIT |
3p14.2 |
pleomorphic salivary gland adenoma |
HMGA2
|
| FIP1L1 |
4q12 |
idiopathic hypereosinophilic syndrome |
PDGFRA
|
| FLI1 |
11q24 |
Ewing sarcoma |
EWSR1
|
| FLT3 |
13q12 |
AML,ALL |
|
| FLT4 |
5q35.3 |
soft tissue sarcoma |
|
| FNBP1 |
9q23 |
AML |
KMT2A
|
| FOXA1 |
14q12-q13 |
breast,prostate |
|
| FOXL2 |
3q23 |
granulosa-cell tumour of the ovary |
|
| FOXO1 |
13q14.1 |
alveolar rhabdomyosarcoma |
PAX3,PAX7
|
| FOXO3 |
6q21 |
AL |
KMT2A
|
| FOXO4 |
Xq13.1 |
AL |
KMT2A
|
FOXO4 |
Xq13.1 |
soft tissue sarcoma |
CIC
|
| FOXP1 |
3p14.1 |
ALL |
PAX5
|
| FSTL3 |
19p13 |
B-CLL |
CCND1
|
| FUBP1 |
1p13.1 |
oligodendroglioma |
|
| FUS |
16p11.2 |
liposarcoma,AML,Ewing sarcoma,angiomatoid fibrous histiocytoma,fibromyxoid sarcoma |
DDIT3,ERG,FEV,ATF1,CREB3L2,CREB3L1,NFATC2
|
| GAS7 |
17p |
AML* |
KMT2A
|
| GATA1 |
Xp11.23 |
megakaryoblastic leukaemia of Downs syndrome |
|
| GATA2 |
3q21.3 |
AML (CML blast transformation) |
|
| GATA3 |
10p15 |
breast |
|
| GMPS |
3q24 |
AML |
KMT2A
|
| GNA11 |
19p13.3 |
uveal melanoma |
|
| GNAQ |
9q21 |
uveal melanoma |
|
| GNAS |
20q13.2 |
pituitary adenoma |
|
| GOLGA5 |
14q |
papillary thyroid,Spitzoid tumour |
RET
|
| GOPC |
6q21 |
glioblastoma |
ROS1
|
| GPHN |
14q24 |
AL |
KMT2A
|
| GRIN2A |
16p13.2 |
melanoma,colorectal carcinoma,gastric carcinoma,lung carcinoma |
|
| H3F3A |
1q42.12 |
glioma |
|
| H3F3B |
17q25.1 |
chondroblastoma |
|
| HERPUD1 |
16q12.2-q13 |
prostate |
ERG
|
| HEY1 |
8q21 |
mesenchymal chondrosarcoma |
NCOA2
|
| HIP1 |
7q11.23 |
CMML,NSCLC |
PDGFRB,ALK
|
| HIST1H3B |
6p22.1 |
glioma |
|
| HIST1H4I |
6p21.3 |
NHL |
BCL6
|
| HLA-A |
6p21.3 |
Spitzoid tumour |
ROS1
|
| HLF |
17q22 |
ALL |
TCF3
|
| HMGA1 |
6p21 |
microfollicular thyroid adenoma,various benign mesenchymal tumours |
Unknown
|
| HMGA2 |
12q15 |
lipoma,leiomyoma,pleomorphic salivary gland adenoma |
LHFP,RAD51B,LPP,COX6C,ACKR3,NFIB,ALDH2,CCNB1IP1,EBF1,WIF1,FHIT
|
| HMGN2P46 |
15q21.1 |
prostate |
ETV1
|
| HNF1A |
12q24.2 |
hepatic adenoma,hepatocellular |
|
| HNRNPA2B1 |
7p15 |
prostate |
ETV1
|
| HOOK3 |
8p11.21 |
papillary thyroid |
RET
|
| HOXA11 |
7p15-p14.2 |
CML |
NUP98
|
| HOXA13 |
7p15-p14.2 |
AML |
NUP98
|
| HOXA9 |
7p15-p14.2 |
AML* |
NUP98,MSI2
|
| HOXC11 |
12q13.3 |
AML |
NUP98
|
| HOXC13 |
12q13.3 |
AML |
NUP98
|
| HOXD11 |
2q31-q32 |
AML |
NUP98
|
| HOXD13 |
2q31-q32 |
AML* |
NUP98
|
| HRAS |
11p15.5 |
infrequent sarcomas,rare other tumour types |
|
| HSP90AA1 |
14q32.33 |
NHL |
BCL6
|
| HSP90AB1 |
6p12 |
NHL |
BCL6
|
| IDH1 |
2q33.3 |
glioblastoma |
|
| IDH2 |
15q26.1 |
glioblastoma |
|
| IGH |
14q32.33 |
MM,Burkitt lymphoma,NHL,CLL,B-ALL,MALT,MLCLS |
MYC,FGFR3,PAX5,FCRL4,IRF4,CCND1,BCL9,BCL8,BCL6,BCL2,BCL3,BCL10,BCL11A. LHX4,DDX6,NFKB2,PAFAH1B2,PCSK7,CRLF2
|
| IGK |
2p12 |
Burkitt lymphoma,B-NHL |
MYC,KDSR
|
| IGL |
22q11.2 |
Burkitt lymphoma |
BCL9,MYC,CCND2
|
| IKBKB |
8p11.2 |
SMZL |
|
| IKZF1 |
7p12.2 |
ALL,DLBCL |
BCL6
|
| IL2 |
4q26-q27 |
intestinal T-cell lymphoma |
TNFRSF17
|
| IL21R |
16p11 |
NHL |
BCL6
|
| IL6ST |
5q11 |
hepatocellular carcinoma |
|
| IL7R |
5p13 |
ALL,ETP ALL |
|
| IRF4 |
6p25-p23 |
MM |
IGH
|
| ITK |
5q31-q32 |
peripheral T-cell lymphoma |
SYK
|
| JAK1 |
1p32.3-p31.3 |
ALL |
|
| JAK2 |
9p24 |
ALL,AML,MPN,CML |
ETV6,PCM1,BCR
|
| JAK3 |
19p13.1 |
acute megakaryocytic leukaemia,ETP ALL |
|
| JAZF1 |
7p15.2-p15.1 |
endometrial stromal tumour |
SUZ12
|
| JUN |
1p32-p31 |
sarcoma |
|
| KAT6A |
8p11 |
AML |
CREBBP,NCOA2,EP300
|
| KAT6B |
10q22.2 |
AML |
CREBBP
|
| KCNJ5 |
11q24 |
adrenal adenoma |
|
| KDM5A |
12p11 |
AML |
NUP98
|
| KDM5C |
Xp11.22-p11.21 |
clear cell renal carcinoma |
|
| KDM6A |
Xp11.2 |
renal cell carcinoma,bladder carcinoma,oesophageal SCC,MM,medulloblastoma,T-ALL,other tumour types |
|
| KDR |
4q11-q12 |
NSCLC,angiosarcoma |
|
| KDSR |
18q21.3 |
B-NHL |
IGK
|
| KIAA1549 |
7q34 |
pilocytic astrocytoma |
BRAF
|
| KIAA1598 |
10q25.3 |
Spitzoid tumour |
ROS1
|
| KIF5B |
10p11.22 |
NSCLC,Spitzoid tumour |
RET,ALK
|
| KIT |
4q12 |
GIST,AML,TGCT,mastocytosis,mucosal melanoma |
|
| KLF4 |
9q31 |
meningioma |
|
| KLF6 |
10p15 |
prostate,glioma |
|
| KLK2 |
19q13.41 |
prostate |
ETV4
|
| KMT2A |
11q23 |
AML,ALL |
KMT2A,MLLT1,AFF1,MLLT3,MLLT4,FOXO4,MLLT10,MLLT6,ELL,EPS15,MLLT11,CREBBP,SH3GL1,FNBP1,SEPT5,SEPT9,GPHN,GMPS,ABI1,ARHGEF12,GAS7,FOXO3,AFF3,TET1,SEPT6,LPP,RUNX1T1,ARHGAP26,EP300,PICALM,CLP1,PRRC1,DAB2IP,MAPRE1,KIAA1524,SEPT2,SARNP,ZFYVE19,TOP3A,CASC5,EEFSEC,FRYL,SORBS2,ABI2,LASP1,CASP8AP2,AFF4,NRIP3,NCKIPSD,CBL,ACTN4,PDS5A,CT45A2,MYO1F,KIAA0284,BTBD18
|
| KMT2C |
7q36.1 |
medulloblastoma |
|
| KMT2D |
12q13.12 |
medulloblastoma,renal |
|
| KRAS |
12p12.1 |
pancreatic,colorectal,lung,thyroid,AML,other tumour types |
|
| KTN1 |
14q22.1 |
papillary thyroid |
RET
|
| LASP1 |
17q11-q21.3 |
AML |
KMT2A
|
| LCK |
1p35-p34.3 |
T-ALL |
TRB
|
| LCP1 |
13q14.1-q14.3 |
NHL |
BCL6
|
| LHFP |
13q12 |
lipoma |
HMGA2
|
| LIFR |
5p13-p12 |
salivary adenoma |
PLAG1
|
| LMNA |
1q22 |
Spitzoid tumour |
NTRK1
|
| LMO1 |
11p15 |
T-ALL,neuroblastoma |
TRD
|
| LMO2 |
11p13 |
T-ALL |
TRD
|
| LPP |
3q28 |
lipoma,leukaemia |
HMGA2,KMT2A,C12orf9
|
| LRIG3 |
12q14.1 |
NSCLC |
ROS1
|
| LSM14A |
19q13.11 |
Spitzoid tumour |
BRAF
|
| LYL1 |
19p13.2-p13.1 |
T-ALL |
TRB
|
| MAF |
16q22-q23 |
MM |
IGH
|
| MAFB |
20q11.2-q13.1 |
MM |
IGH
|
| MALAT1 |
11q31.1 |
renal cell carcinoma (childhood epithelioid),lung |
TFEB
|
| MALT1 |
18q21 |
MALT |
BIRC3
|
| MAML2 |
11q22-q23 |
salivary gland mucoepidermoid |
CRTC3,CRTC1
|
| MAP2K1 |
15q22.1-q22.33 |
NSCLC,melanoma,colorectal |
|
| MAP2K2 |
19p13.3 |
NSCLC,melanoma |
|
| MAP2K4 |
17p11.2 |
pancreatic,breast,colorectal |
|
| MAP3K1 |
5q11.2 |
luminal A breast |
|
| MAP3K13 |
3q27 |
breast |
|
| MAX |
14q23 |
pheochromocytoma,endometrioid carcinoma,colon carcinoma |
|
| MDM2 |
12q15 |
sarcoma,glioma,colorectal,other tumour types |
|
| MDM4 |
1q32 |
glioblastoma,bladder,retinoblastoma |
|
| MDS2 |
1p36 |
MDS |
ETV6
|
| MECOM |
3q26.2 |
AML,CML,MDS |
RUNX1,ETV6,PRDM16,RPN1
|
| MED12 |
Xq13 |
uterine leiomyoma |
|
| MEN1 |
11q13 |
parathyroid tumours,pancreatic neuroendocrine tumour |
|
| MET |
7q31 |
papillary renal,head-neck squamous cell |
|
| MITF |
3p14.1 |
melanoma |
|
| MKL1 |
22q13 |
acute megakaryocytic leukaemia |
RBM15
|
| MLF1 |
3q25.1 |
AML |
NPM1
|
| MLH1 |
3p21.3 |
colorectal,endometrial,ovarian,CNS tumours |
|
| MLLT1 |
19p13.3 |
AL |
KMT2A
|
| MLLT10 |
10p12 |
AL |
KMT2A,PICALM,CDK6
|
| MLLT11 |
1q21 |
ALL |
KMT2A
|
| MLLT3 |
9p22 |
ALL |
KMT2A
|
| MLLT4 |
6q27 |
AL |
KMT2A
|
| MLLT6 |
17q21 |
AL |
KMT2A
|
| MN1 |
22q13 |
AML,meningioma |
ETV6
|
| MNX1 |
7q36 |
AML |
ETV6
|
| MPL |
1p34 |
MPN |
|
| MSH2 |
2p22-p21 |
colorectal,endometrial,ovarian |
|
| MSH6 |
2p16 |
colorectal |
|
| MSI2 |
17q23.2 |
CML |
HOXA9
|
| MSN |
Xq11.2-q12 |
ALCL |
ALK
|
| MTCP1 |
Xq28 |
T cell prolymphocytic leukaemia |
TRA
|
| MUC1 |
1q21 |
B-NHL |
IGH
|
| MYB |
6q22-23 |
adenoid cystic carcinoma |
NFIB
|
| MYC |
8q24.12-q24.13 |
Burkitt lymphoma,amplified in other cancers,B-CLL |
IGK,BCL5,BCL7A ,BTG1,TRA,IGH
|
| MYCL |
1p34.2 |
small cell lung carcinoma |
|
| MYCN |
2p24.1 |
neuroblastoma |
|
| MYD88 |
3p22 |
ABC-DLBCL |
|
| MYH11 |
16p13.13-p13.12 |
AML |
CBFB
|
| MYH9 |
22q13.1 |
ALCL |
ALK
|
| MYO5A |
15q21 |
Spitzoid tumour |
ROS1
|
| MYOD1 |
11p15.4 |
embryonal rhabdomyosarcoma |
|
| NAB2 |
12q13.3 |
solitary fibrous tumour,meningeal haemangiopericytoma |
STAT6
|
| NACA |
12q23-q24.1 |
NHL |
BCL6
|
| NCKIPSD |
3p21 |
ALL |
KMT2A
|
| NCOA1 |
2p23 |
alveolar rhabdomyosarcoma |
PAX3
|
| NCOA2 |
8q13.1 |
AML,chondrosarcoma,rhabdomyosarcoma |
KAT6A,HEY1,NCOA2
|
| NCOA4 |
10q11.2 |
papillary thyroid |
RET
|
| NCOR1 |
17p11.2 |
breast |
|
| NDRG1 |
8q24.3 |
prostate |
ERG
|
| NF1 |
17q12 |
neurofibroma,glioma |
|
| NF2 |
22q12.2 |
meningioma,acoustic neuroma,renal |
|
| NFATC2 |
20q13.2 |
Ewing sarcoma |
EWSR1
|
| NFE2L2 |
2q31 |
NSCLC,HNSCC |
|
| NFIB |
9p24.1 |
adenoid cystic carcinoma,lipoma |
MYB,HGMA2
|
| NFKB2 |
10q24 |
B-NHL |
IGH
|
| NFKBIE |
6p21.1 |
CLL |
|
| NIN |
14q24 |
MPN |
PDGFRB
|
| NKX2-1 |
14q13 |
NSCLC |
|
| NONO |
Xq13.1 |
papillary renal |
TFE3
|
| NOTCH1 |
9q34.3 |
T-ALL,breast,bladder,skin SCC,lung SCC,head and neck SCC |
TRB,SEC16A,GABBR2
|
| NOTCH2 |
1p13-p11 |
marginal zone lymphoma,DLBCL,bladder |
|
| NPM1 |
5q35 |
NHL,APL,AML |
ALK,RARA,MLF1
|
| NR4A3 |
9q22 |
extraskeletal myxoid chondrosarcoma |
EWSR1,TAF15,TCF12,TFG
|
| NRAS |
1p13.2 |
melanoma,MM,AML,thyroid |
|
| NRG1 |
8p12 |
NSCLC |
CD74
|
| NSD1 |
5q35 |
AML |
NUP98
|
| NT5C2 |
10q24.32 |
relapse ALL |
|
| NTRK1 |
1q21-q22 |
papillary thyroid,Spitzoid tumour |
TPM3,TPR,TFG,TP53,LMNA
|
| NTRK3 |
15q25 |
congenital fibrosarcoma,secretory breast |
ETV6
|
| NUMA1 |
11q13 |
APL |
RARA
|
| NUP214 |
9q34.1 |
AML,T-ALL |
DEK,SET,ABL1
|
| NUP98 |
11p15 |
AML |
HOXA9,NSD1,WHSC1L1,DDX10,TOP1,HOXD13,PRRX1,HOXA13,HOXD11,HOXA11,RAP1GDS1,HOXC11
|
| NUTM1 |
15q14 |
lethal midline carcinoma |
BRD3,BRD4
|
| NUTM2A |
10q23.2 |
endometrial stromal sarcoma |
YWHAE
|
| NUTM2B |
10q22.3 |
endometrial stromal sarcoma |
YWHAE
|
| OLIG2 |
21q22.11 |
T-ALL |
TRA
|
| OMD |
9q22.31 |
aneurysmal bone cyst |
USP6
|
| P2RY8 |
Xp22.3; Yp11.3 |
B-ALL,Down syndrome associated ALL |
CRLF2
|
| PAFAH1B2 |
11q23 |
MLCLS |
IGH
|
| PAX3 |
2q35 |
alveolar rhabdomyosarcoma |
FOXO1,NCOA1,NCOA2
|
| PAX5 |
9p13 |
NHL,ALL,B-ALL |
IGH,ETV6,PML,FOXP1,ZNF521,ELN
|
| PAX7 |
1p36.2-p36.12 |
alveolar rhabdomyosarcoma |
FOXO1
|
| PAX8 |
2q12-q14 |
follicular thyroid |
PPARG
|
| PBRM1 |
3p21 |
clear cell renal carcinoma,breast |
|
| PBX1 |
1q23 |
pre B-ALL,myoepithelioma |
TCF3,EWSR1
|
| PCM1 |
8p22-p21.3 |
papillary thyroid,CML,MPN |
RET,JAK2
|
| PCSK7 |
11q23.3 |
MLCLS |
IGH
|
| PDCD1LG2 |
9p24.2 |
PMBL,Hodgkin lymphoma |
CIITA
|
| PDE4DIP |
1q12 |
MPN |
PDGFRB
|
| PDGFB |
22q12.3-q13.1 |
DFSP |
COL1A1
|
| PDGFRA |
4q11-q13 |
GIST,idiopathic hypereosinophilic syndrome,paediatric glioblastoma |
FIP1L1
|
| PDGFRB |
5q31-q32 |
MPN,AML,CMML,CML |
ETV6,TRIP11,HIP1,RABEP1,H4,NIN,SPECC1,PDE4DIP
|
| PER1 |
17p13.1-17p12 |
AML,CMML |
ETV6
|
| PHF6 |
Xq26.3 |
ETP ALL |
|
| PHOX2B |
4p12 |
neuroblastoma |
|
| PICALM |
11q14 |
T-ALL,AML |
MLLT10,KMT2A
|
| PIK3CA |
3q26.3 |
colorectal,gastric,glioblastoma,breast |
|
| PIK3R1 |
5q13.1 |
glioblastoma,ovarian,colorectal |
|
| PIM1 |
6p21.2 |
NHL |
BCL6
|
| PLAG1 |
8q12 |
salivary adenoma,lipoblastoma |
TCEA1,LIFR,CTNNB1,CHCHD7,COL1A2,HAS2
|
| PLCG1 |
20q12-q13.1 |
angiosarcoma |
|
| PML |
15q22 |
APL,ALL |
RARA,PAX5
|
| POLE |
12q24.3 |
colorectal carcinoma,endometrioid carcinoma,stomach carcinoma,skin cancer |
|
| POT1 |
7q31.33 |
CLL |
|
| POU2AF1 |
11q23.1 |
NHL |
BCL6
|
| POU5F1 |
6p21.31 |
sarcoma |
EWSR1
|
| PPARG |
3p25 |
follicular thyroid |
PAX8
|
| PPFIBP1 |
12p12.1 |
Spitzoid tumour,inflammatory myofibroblastic tumour |
ROS1,ALK
|
| PPP2R1A |
19q13.41 |
clear cell ovarian carcinoma |
|
| PPP6C |
9q33.3 |
melanoma |
|
| PRCC |
1q21.1 |
papillary renal |
TFE3
|
| PRDM1 |
6q21 |
DLBCL |
|
| PRDM16 |
1p36.23-p33 |
MDS,AML |
MECOM
|
| PRKAR1A |
17q23-q24 |
papillary thyroid |
RET
|
| PRRX1 |
1q24 |
AML |
NUP98
|
| PSIP1 |
9p22.3 |
AML |
NUP98
|
| PTCH1 |
9q22.3 |
skin basal cell,medulloblastoma |
|
| PTEN |
10q23.3 |
glioma,prostate,endometrial |
|
| PTPN11 |
12q24.1 |
JMML,AML,MDS |
|
| PTPRB |
12q15-q21 |
angiosarcoma |
|
| PTPRC |
1q31-q32 |
T-ALL |
|
| PTPRK |
6q22.2-q22.3 |
colorectal |
RSPO3
|
| PWWP2A |
5q33.3 |
Spitzoid tumour |
ROS1
|
| RABEP1 |
17p13.2 |
CMML |
PDGFRB
|
| RAC1 |
7p22 |
melanoma,carcinoma |
|
| RAD21 |
8q24.11 |
AML,endometrium,colorectal,lung |
|
| RAD51B |
14q23-q24.2 |
lipoma,uterine leiomyoma |
HMGA2
|
| RAF1 |
3p25 |
pilocytic astrocytoma,prostate |
SRGAP3,ESRP1
|
| RALGDS |
9q34.3 |
PMBL,Hodgkin lymphoma, |
CIITA
|
| RANBP17 |
5q34 |
ALL |
TRD
|
| RANBP2 |
2q12.3 |
inflammatory myofibroblastic tumour |
ALK
|
| RAP1GDS1 |
4q21-q25 |
T-ALL |
NUP98
|
| RARA |
17q12 |
APL |
PML,ZBTB16,TRIM24,NUMA1,NPM1
|
| RB1 |
13q14 |
retinoblastoma,sarcoma,breast,small cell lung carcinoma |
|
| RBM15 |
1p13 |
acute megakaryocytic leukaemia |
MKL1
|
| REL |
2p13-p12 |
Hodgkin lymphoma |
|
| RET |
10q11.2 |
medullary thyroid,papillary thyroid,pheochromocytoma,NSCLC,Spitzoid tumour |
H4,PRKAR1A,NCOA4,PCM1,GOLGA5,TRIM33,KTN1,TRIM27,HOOK3,KIF5B,CCDC6
|
| RHOA |
3p21.3 |
diffuse gastric,T cell lymphomas,paediatric Burkitt lymphoma |
|
| RHOH |
4p13 |
NHL |
BCL6
|
| RMI2 |
16p13.13 |
PMBL,Hodgkin lymphoma |
CIITA
|
| RNF213 |
17q25.3 |
ALCL |
ALK
|
| RNF217-AS1 |
6q22.33 |
B-ALL |
ETV6
|
| RNF43 |
17q23.2 |
cholangiocarcinoma,ovary,pancreas |
|
| ROS1 |
6q22 |
glioblastoma,NSCLC,Spitzoid tumour |
GOPC,SDC4,SLC34A2,EZR,LRIG3,HLA-A,MYO5A,PPFIBP1,ERC1,CLIP1,TPM3,ZCCHHC8,KIAA1598,PWWP2A
|
| RPL10 |
Xq28 |
T-ALL |
|
| RPL22 |
1p36.31 |
AML,CML |
RUNX1
|
| RPL5 |
1p22.1 |
T-ALL |
|
| RPN1 |
3q21.3-q25.2 |
AML |
MECOM
|
| RSPO2 |
8q23.1 |
colorectal |
EIF3E
|
| RSPO3 |
6q22.33 |
colorectal |
PTPRK
|
| RUNDC2A |
16p13.13 |
PMBL,Hodgkin lymphoma |
CIITA
|
| RUNX1 |
21q22.3 |
AML,preB- ALL,T-ALL |
RPL22,MECOM,CBFA2T3,RUNX1T1,ETV6,AFF3
|
| RUNX1T1 |
8q22 |
AML |
KMT2A,RUNX1
|
| SDC4 |
20q12 |
NSCLC |
ROS1
|
| SET |
9q34 |
AML |
NUP214
|
| SETBP1 |
18q21.1 |
aCML,sAML,MDS/MPN-U,CMML,JMML |
NUP98
|
| SETD2 |
3p21.31 |
clear cell renal carcinoma |
|
| SF3B1 |
2q33.1 |
myelodysplastic syndrome |
|
| SFPQ |
1p34.3 |
papillary renal |
TFE3
|
| SH2B3 |
12q24.12 |
MPN,sAML,erythrocytosis,B-ALL |
|
| SH3GL1 |
19p13.3 |
AL |
KMT2A
|
| SLC34A2 |
4p15.2 |
NSCLC |
ROS1
|
| SLC45A3 |
1q32 |
prostate |
ETV1,ETV5,ELK4,ERG,BRAF
|
| SMAD4 |
18q21.1 |
colorectal,pancreatic,small intestine |
|
| SMARCA4 |
19p13.2 |
NSCLC,SCCOHT |
|
| SMARCB1 |
22q11 |
malignant rhabdoid |
|
| SMARCD1 |
12q13-q14 |
breast |
|
| SMO |
7q31-q32 |
skin basal cell |
|
| SND1 |
7q31.3 |
pancreas acinar carcinoma |
BRAF
|
| SOCS1 |
16p13.13 |
Hodgkin lymphoma,PMBL |
|
| SOX2 |
3q26.3-q27 |
NSCLC,oesophageal squamous carcinoma |
|
| SPECC1 |
17p11.2 |
JMML |
PDGFRB
|
| SPEN |
1p36 |
SMZL,adenoid cystic carcinoma,DLBCL |
|
| SPOP |
17q21.33 |
prostate,serous endometrial |
|
| SRGAP3 |
3p25.3 |
pilocytic astrocytoma |
RAF1
|
| SRSF2 |
17q25 |
MDS,CLL |
|
| SRSF3 |
6p21 |
follicular lymphoma |
BCL6
|
| SS18 |
18q11.2 |
synovial sarcoma |
SSX1,SSX2,SSX4
|
| SS18L1 |
20q13.3 |
synovial sarcoma |
SSX1
|
| SSX1 |
Xp11.23-p11.22 |
synovial sarcoma |
SS18
|
| SSX2 |
Xp11.23-p11.22 |
synovial sarcoma |
SS18
|
| SSX4 |
Xp11.23 |
synovial sarcoma |
SS18
|
| STAG2 |
Xq25 |
bladder carcinoma,glioblastoma,melanoma,Ewing's sarcoma,myeloid neoplasms |
|
| STAT3 |
17q21.31 |
T-cell large granular lymphocytic leukaemia |
|
| STAT5B |
17q11.2 |
large granular lymphocytic leukaemia,skin basal cell,APL |
RARA
|
| STAT6 |
12q13 |
solitary fibrous tumour,meningeal haemangiopericytoma |
NAB2
|
| STIL |
1p32 |
T-ALL |
TAL1
|
| STK11 |
19p13.3 |
NSCLC,pancreatic |
|
| STRN |
2p22.2 |
anaplastic thyroid,papillary thyroid,lung |
ALK
|
| SUFU |
10q24.32 |
medulloblastoma |
|
| SUZ12 |
17q11.2 |
endometrial stromal tumour |
JAZF1
|
| SYK |
9q22 |
MDS,peripheral T-cell lymphoma |
ETV6,ITK
|
| TAF15 |
17q11.1-q11.2 |
extraskeletal myxoid chondrosarcoma,ALL |
NR4A3,CHN1,ZNF384
|
| TAL1 |
1p32 |
lymphoblastic leukaemia/biphasic |
TRD,STIL
|
| TAL2 |
9q31 |
T-ALL |
TRB
|
| TBL1XR1 |
3q26.32 |
splenic marginal zone lymphoma,primary central nervous system lymphoma,colorectal carcinoma,gallbladder carcinoma |
|
| TBX3 |
12q24.21 |
breast |
|
| TCEA1 |
8q11.2 |
salivary adenoma |
PLAG1
|
| TCF12 |
15q21 |
extraskeletal myxoid chondrosarcoma |
NR4A3
|
| TCF3 |
19p13.3 |
pre B-ALL |
PBX1,HLF,TFPT
|
| TCF7L2 |
10q25.3 |
colorectal |
VTI1A
|
| TCL1A |
14q32.1 |
T-CLL |
TRA
|
| TCL6 |
14q32.1 |
T-ALL |
TRA
|
| TERT |
5p15.33 |
melanoma,glioblastoma,hepatocellular carcinoma,bladder,skin basal cell,skin squamous cell,mesothelioma,medulloblastoma,other tumour types |
|
| TET1 |
10q21 |
AML |
KMT2A
|
| TET2 |
4q24 |
MDS |
|
| TFE3 |
Xp11.22 |
papillary renal,alveolar soft part sarcoma,renal |
SFPQ,ASPSCR1,PRCC,NONO,CLTC
|
| TFEB |
6p21 |
renal cell carcinoma (childhood epithelioid) |
ALPHA
|
| TFG |
3q11-q12 |
papillary thyroid,ALCL,NSCLC,extraskeletal myxoid chondrosarcoma |
NTRK1,ALK,NR4A3
|
| TFPT |
19q13 |
pre-B ALL |
TCF3
|
| TFRC |
3q29 |
NHL |
BCL6
|
| THRAP3 |
1p34.3 |
aneurysmal bone cyst |
USP6
|
| TLX1 |
10q24 |
T-ALL |
TRB,TRD
|
| TLX3 |
5q35.1 |
T-ALL |
BCL11B
|
| TMPRSS2 |
21q22.3 |
prostate |
ERG,ETV1,ETV4,ETV5
|
| TNFAIP3 |
6q23 |
marginal zone B-cell lymphomas,Hodgkin lymphoma,PMBL |
|
| TNFRSF14 |
1p36.32 |
follicular lymphoma |
|
| TNFRSF17 |
16p13.1 |
intestinal T-cell lymphoma |
IL2
|
| TOP1 |
20q12-q13.1 |
AML* |
NUP98
|
| TP53 |
17p13 |
breast,colorectal,lung,sarcoma,adrenocortical,glioma,Spitzoid tumour,multiple other tumour types |
NTRK1
|
| TPM3 |
1q22-q23 |
papillary thyroid,ALCL,NSCLC,Spitzoid tumour |
NTRK1,ALK,ROS1
|
| TPM4 |
19p13.1 |
ALCL |
ALK
|
| TPR |
1q25 |
papillary thyroid,NSCLC |
NTRK1,ALK
|
| TRA |
14q11.2 |
T-ALL |
ATL,OLIG2,MYC,TCL1A,TCL6,MTCP1,TCL6
|
| TRAF7 |
16p13.3 |
meningioma |
|
| TRB |
7q34 |
T-ALL |
HOX11,LCK,NOTCH1,TAL2,LYL1
|
| TRD |
14q11.2 |
T-cell leukaemia |
TAL1,HOX11,TLX1,LMO1,LMO2,RANBP17
|
| TRIM24 |
7q32-q34 |
APL |
RARA
|
| TRIM27 |
6p22 |
papillary thyroid |
RET
|
| TRIM33 |
1p13 |
papillary thyroid |
RET
|
| TRIP11 |
14q31-q32 |
AML |
PDGFRB
|
| TRRAP |
7q21.2-q22.1 |
melanoma |
|
| TSC1 |
9q34 |
renal cell carcinoma,bladder carcinoma |
|
| TSC2 |
16p13.3 |
pulmonary lymphangioleiomyomatosis (LAM),renal angiomyolipoma,HNSCC |
|
| TSHR |
14q31 |
toxic thyroid adenoma |
|
| TTL |
2q13 |
ALL |
ETV6
|
| U2AF1 |
21q22.3 |
CLL,MDS |
|
| UBR5 |
8q22 |
mantle cell lymphoma,gastric,colorectal |
|
| USP6 |
17p13 |
aneurysmal bone cyst |
COL1A1,CDH11,CNBP,OMD,THRAP3
|
| VHL |
3p25 |
renal,haemangioma,pheochromocytoma |
|
| VTI1A |
10q25.2 |
colorectal |
TCF7L2
|
| WHSC1 |
4p16.3 |
MM |
IGH
|
| WHSC1L1 |
8p12 |
AML |
NUP98
|
| WIF1 |
12q14.3 |
pleomorphic salivary gland adenoma |
HMGA2
|
| WT1 |
11p13 |
Wilms tumour,desmoplastic small round cell tumour |
EWSR1
|
| WWTR1 |
3q23-q24 |
epithelioid haemangioendothelioma |
CAMTA1
|
| XPO1 |
2p15 |
CLL |
|
| YWHAE |
17p13.3 |
endometrial stromal sarcoma |
NUTM2A,NUTM2B
|
| ZBTB16 |
11q23.1 |
APL |
RARA
|
| ZCCHC8 |
12q24.31 |
Spitzoid tumour |
ROS1
|
| ZNF198 |
13q11-q12 |
MPN,NHL |
FGFR1
|
| ZNF278 |
22q12-q14 |
Ewing sarcoma |
EWSR1
|
| ZNF331 |
19q13.3-q13.4 |
follicular thyroid adenoma |
Unknown
|
| ZNF384 |
12p13 |
ALL |
EWSR1,TAF15
|
| ZNF521 |
18q11.2 |
ALL |
PAX5
|
| ZRSR2 |
Xp22.1 |
MDS,CLL |
|