Translocations et al. in Hematological Cancers
Acknowledgement
This list is based on the Mayo Clinic Hematologic Cytogenetics Reference Sheet, November 2012.
Translocations
Inversions
| ANOMALY | ASSOCIATED DISORDERS with FISH test | GENES |
| inv(3)(q21q26.2) | MDS,AML | RPN1-MECOM(EVI1) |
| inv(11)(q21q23) | MDS,AML M2,T-ALL | MAML2-MLL |
| inv(14)(q11.2q32) | PLL | TRA-TCL1A(TCL1) |
| inv(16)(p13.1q22) | AML M4Eo | MYH11-CBFB |
Duplications
| ANOMALY | ASSOCIATED DISORDERS with FISH test | GENES |
| dup(1)(q11q44) | ||
| dup(1)(q21q32) | B-ALL,NHL | |
| dup(1)(q21q42) | ||
| dup(1)(q23q32) | ||
| dup(1)(q23q42) | NHL | |
| dup(11)(q13q25) | NHL | MLL |
| dup(12)(q13q22) |
Isochromsomes
| ANOMALY | ASSOCIATED DISORDERS with FISH test | GENES |
| i(1)(q10) | NHL | |
| i(3)(q10) | NHL | |
| i(7)(q10) | T-cell lymphoma | |
| i(8)(q10) | T-ALL,AML,B-ALL | |
| i(11)(q10) | AML M2,AML M4,MDS | |
| i(17)(q10) | MDS,MPD,AML,CML,B-ALL,CLL,Hodgkin and NHL | |
| i(21)(q10) | B-ALL,MDS,NHL,AML,CMML | |
| idic(X)(q13) | AML M1,M2,M4,MDS,RARS | XIST |
Cryptic
| ANOMALY | ASSOCIATED DISORDERS with FISH test | GENES |
| t(12;21)(p13;q22) | B-ALL | ETV6 (TEL)-RUNX1(AML1) |
| t(X;14) and t(Y;14) | B-ALL | IGH-CRLF2 |
| t(5;14)(q35;q32) | T-ALL | TLX3-BCL11B |
| del(1)(p32p32) | T-ALL | SIL(STIL)-TAL1 |
Deletions
Numerical Abnormalities
| ANOMALY | ASSOCIATED DISORDERS with FISH test |
| +3 | SLVL,T-cell lymphoma,MZL,MCL,MALT |
| +4 | AML M1-M2 and M4,and treatment related AML |
| +8 | B-ALL,AML,MPD,MDS,PV |
| +9 | AML,MDS,MPD,PV,B-ALL,T-ALL |
| +10 | AML,B-ALL,MDS |
| +11 | AML M1,M2,M4,MDS |
| +12 | AML,CLL,NHL,MALT,HCL,SLVL,WM/LPL,FL,MCL and DLBCL |
| +13/+13,+13 | AML-M0 |
| +14 | MDS RA,RAEB±T mainly,AML M1,M2,M4,atypical MPD |
| +15 | Age related when sole anomaly or with -Y |
| +19 | AML,MDS |
| +21 | AML,B-ALL,MDS,MPD |
| +22 | AML-M4eo |
| -7 | MDS,RAEB/RAEB±T,CMML,J-CML,AML most often M4 or M6. |
| -Y | age related when sole anomaly |