Difference between revisions of "Myeloid Neoplasms with Germline Predisposition"

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==General Disease Overview / Description of Cancer Category==
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==Epidemiology / Prevalence==
 
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==Clinical Features==
 
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==Morphologic Features==
 
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==Immunophenotype==
 
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! Finding  !! Marker
 
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|Positive (universal) || EXAMPLE CD1
 
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|Positive (subset) || EXAMPLE CD2
 
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|Negative (universal) || EXAMPLE CD3
 
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|Negative (subset) || EXAMPLE CD4
 
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==Chromosomal Rearrangements (Gene Fusions)==
 
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! Chromosomal Rearrangement !! Genes in Fusion (5’ or 3’ Segments) !! Pathogenic Derivative !! Prevalence
 
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|EXAMPLE t(9;22)(q34;q11.2) || EXAMPLE 3'ABL1 / 5'BCR || EXAMPLE der(22) || EXAMPLE 5%
 
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|EXAMPLE t(8;21)(q22;q22) || EXAMPLE 5'RUNX1 / 3'RUNXT1 || EXAMPLE der(8) || EXAMPLE 5%
 
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==Characteristic Chromosomal Aberrations / Patterns==
 
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! Chromosome Number !! Gain/Loss/Amp/LOH !! Region
 
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|EXAMPLE 8 || EXAMPLE Gain || EXAMPLE chr8:0-1000000
 
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|EXAMPLE 7 || EXAMPLE Loss || EXAMPLE chr7:0-1000000
 
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! Gene !! Mutation !! Oncogene/Tumor Suppressor/Other !! Presumed Mechanism (LOF/GOF/Other; Driver/Passenger) !! Prevalence (COSMIC/TCGA/Other)
 
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| EXAMPLE TP53 || EXAMPLE R273H || EXAMPLE Tumor Suppressor || EXAMPLE LOF || EXAMPLE 20%
 
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==Epigenomics (Methylation)==
 
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==Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications)==
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==WHO Classification Pages (Includes Links to Content)==
  
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==Familial Forms==
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==Other Related Pages (Includes Links to Content)==
  
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Put your text here, EXAMPLE #[[Acute Myeloid Leukemia (AML) with Mutated FLT3]]
  
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==Other Information==
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==Additional Information==
  
 
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==References==
 
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=== EXAMPLE Book ===
 
=== EXAMPLE Book ===
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#Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4thedition.Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.
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#Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.
  
 
=== EXAMPLE Journal Article ===
 
=== EXAMPLE Journal Article ===

Revision as of 20:35, 8 June 2019

Primary Author(s)*

Put your text here

General Disease Overview / Description of Cancer Category

Put your text here

WHO Classification Pages (Includes Links to Content)

Put your text here, EXAMPLE #Chromophobe renal cell carcinoma

Other Related Pages (Includes Links to Content)

Put your text here, EXAMPLE #Acute Myeloid Leukemia (AML) with Mutated FLT3

Additional Information

Put your text here

References

EXAMPLE Book

  1. Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.

EXAMPLE Journal Article

  1. Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.

Notes

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