Difference between revisions of "Global Template"
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==Immunophenotype== | ==Immunophenotype== | ||
− | Put your text here or fill in the table | + | Put your text here and/or fill in the table |
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|Negative (subset) || EXAMPLE CD4 | |Negative (subset) || EXAMPLE CD4 | ||
|} | |} | ||
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==Chromosomal Rearrangements (Gene Fusions)== | ==Chromosomal Rearrangements (Gene Fusions)== | ||
− | Put your text here or fill in the table | + | Put your text here and/or fill in the table |
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
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! Chromosomal Rearrangement !! Genes in Fusion (5’ or 3’ Segments) !! Pathogenic Derivative !! Prevalence | ! Chromosomal Rearrangement !! Genes in Fusion (5’ or 3’ Segments) !! Pathogenic Derivative !! Prevalence | ||
|- | |- | ||
− | |EXAMPLE t(9;22) || EXAMPLE BCR | + | |EXAMPLE t(9;22)(q34;q11.2) || EXAMPLE 3'ABL1 / 5'BCR || EXAMPLE der(22) || EXAMPLE 5% |
|- | |- | ||
− | |EXAMPLE t(8;21) || EXAMPLE RUNX1 | + | |EXAMPLE t(8;21)(q22;q22) || EXAMPLE 5'RUNX1 / 3'RUNXT1 || EXAMPLE der(8) || EXAMPLE 5% |
|} | |} | ||
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==Characteristic Chromosomal Aberrations / Patterns== | ==Characteristic Chromosomal Aberrations / Patterns== | ||
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==Genomic Gain/Loss/LOH== | ==Genomic Gain/Loss/LOH== | ||
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{| class="wikitable sortable" | {| class="wikitable sortable" | ||
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|} | |} | ||
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==Gene Mutations (SNV/INDEL)== | ==Gene Mutations (SNV/INDEL)== | ||
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===Other Mutations=== | ===Other Mutations=== | ||
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| Concomitant Mutations || EXAMPLE IDH1 R123H | | Concomitant Mutations || EXAMPLE IDH1 R123H | ||
|- | |- | ||
− | | Secondary Mutations || EXAMPLE | + | | Secondary Mutations || EXAMPLE Trisomy 7 |
|- | |- | ||
− | |Mutually Exclusive || | + | |Mutually Exclusive || EXAMPLE EGFR Amplification |
|} | |} | ||
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=== EXAMPLE Book === | === EXAMPLE Book === | ||
− | #Arber DA, | + | #Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4thedition.Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118. |
=== EXAMPLE Journal Article === | === EXAMPLE Journal Article === | ||
− | #Li Y, | + | #Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691. |
== Notes == | == Notes == | ||
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome. | <nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome. |
Revision as of 17:14, 7 May 2017
Primary Author(s)*
Cancer Category/Type
Put your text here
Cancer Sub-Classification / Subtype
Put your text here
Definition / Description of Disease
Put your text here
Synonyms / Terminology
Put your text here
Epidemiology / Prevalence
Put your text here
Clinical Features
Put your text here
Sites of Involvement
Put your text here
Morphologic Features
Put your text here
Immunophenotype
Put your text here and/or fill in the table
Finding | Marker |
---|---|
Positive (universal) | EXAMPLE CD1 |
Positive (subset) | EXAMPLE CD2 |
Negative (universal) | EXAMPLE CD3 |
Negative (subset) | EXAMPLE CD4 |
Chromosomal Rearrangements (Gene Fusions)
Put your text here and/or fill in the table
Chromosomal Rearrangement | Genes in Fusion (5’ or 3’ Segments) | Pathogenic Derivative | Prevalence |
---|---|---|---|
EXAMPLE t(9;22)(q34;q11.2) | EXAMPLE 3'ABL1 / 5'BCR | EXAMPLE der(22) | EXAMPLE 5% |
EXAMPLE t(8;21)(q22;q22) | EXAMPLE 5'RUNX1 / 3'RUNXT1 | EXAMPLE der(8) | EXAMPLE 5% |
Characteristic Chromosomal Aberrations / Patterns
Put your text here
Genomic Gain/Loss/LOH
Put your text here and/or fill in the table
Chromosome Number | Gain/Loss/Amp/LOH | Region |
---|---|---|
EXAMPLE 8 | EXAMPLE Gain | EXAMPLE chr8:0-1000000 |
EXAMPLE 7 | EXAMPLE Loss | EXAMPLE chr7:0-1000000 |
Gene Mutations (SNV/INDEL)
Put your text here and/or fill in the tables
Gene | Mutation | Oncogene/Tumor Suppressor/Other | Presumed Mechanism (LOF/GOF/Other; Driver/Passenger) | Prevalence (COSMIC/TCGA/Other) |
---|---|---|---|---|
EXAMPLE TP53 | EXAMPLE R273H | EXAMPLE Tumor Suppressor | EXAMPLE LOF | EXAMPLE 20% |
Other Mutations
Type | Gene/Region/Other |
---|---|
Concomitant Mutations | EXAMPLE IDH1 R123H |
Secondary Mutations | EXAMPLE Trisomy 7 |
Mutually Exclusive | EXAMPLE EGFR Amplification |
Epigenomics (Methylation)
Put your text here
Genes and Main Pathways Involved
Put your text here
Diagnostic Testing Methods
Put your text here
Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications)
Put your text here
Familial Forms
Put your text here
Other Information
Put your text here
Links
Put your links here
References
EXAMPLE Book
- Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4thedition.Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.
EXAMPLE Journal Article
- Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.
Notes
*Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.