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Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray (view source)
Revision as of 09:10, 16 November 2018
, 09:10, 16 November 2018no edit summary
PMID:25965575; PMID:21627842; PMID:24939246; PMID:22516549
PMID:25965575; PMID:21627842; PMID:24939246; PMID:22516549
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|Classic ependymoma (no WHO grade assigned)
|'''Gain:''' 1q, 5, 7, 9, 11, 18, 20<br>
'''Loss:''' 1p, 3, -6/6q, 9p, 13q, 17, 22
|Usually intracranial, spinal tumors (myxopapillary) are rare; 80% of pediatric tumors develop in posterior fossa (PF); Supratentorial tumors preferentially show monosomy 9; 1q gain is unfavorable prognostic indicator in PF tumors; spinal tumors associated with NF2 (germline); children have worse outcomes than adults
|PMID:25965575; PMID:22338015; PMID:28371821
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|Subependymoma, WHO grade I
|Typically '''balanced genomes'''<br>
'''Loss:''' -6/6q in spinal tumors
|No diagnostic mutations
|Favorable prognosis
|WHO CNS Tumors (2016) <br>
PMID:21959044; PMID:21840481<br>
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|Myxopapillary ependymoma, WHO grade I
|'''Aneuploidy:''' multiple chromosomes lost and gained
|'''Mutation:''' NF2 (including germline) in spinal tumors
|Less common but more aggressive in children
|PMID:25965575; PMCID:3991130; PMID:20425037; PMID:25957288; PMID:25965575; PMID:22516549
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