Difference between revisions of "Global Template"
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! Chromosome Number !! Gain/Loss/Amp/LOH !! Region | ! Chromosome Number !! Gain/Loss/Amp/LOH !! Region | ||
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− | | 8 || Gain || chr8:0-1000000 | + | |EXAMPLE 8 || EXAMPLE Gain || EXAMPLE chr8:0-1000000 |
|- | |- | ||
− | |7 || Loss || chr7:0-1000000 | + | |EXAMPLE 7 || EXAMPLE Loss || EXAMPLE chr7:0-1000000 |
|} | |} | ||
Revision as of 05:06, 2 May 2017
Primary Author(s)*
Cancer Category/Type
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Cancer Sub-Classification / Subtype
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Definition / Description of Disease
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Synonyms / Terminology
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Epidemiology / Prevalence
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Clinical Features
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Sites of Involvement
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Morphologic Features
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Immunophenotype
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Finding | Marker |
---|---|
Positive (universal) | EXAMPLE CD1 |
Positive (subset) | EXAMPLE CD2 |
Negative (universal) | EXAMPLE CD3 |
Negative (subset) | EXAMPLE CD4 |
Additional Description:
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Chromosomal Rearrangements (Gene Fusions)
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Chromosomal Rearrangement | Genes in Fusion (5’ or 3’ Segments) | Pathogenic Derivative | Prevalence |
---|---|---|---|
EXAMPLE t(9;22) | EXAMPLE BCR-ABL1 | EXAMPLE der(22) | EXAMPLE 5% |
EXAMPLE t(8;21) | EXAMPLE RUNX1-RUNXT1 | EXAMPLE der(8) | 5% |
Additional Description:
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Characteristic Chromosomal Aberrations / Patterns
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Genomic Gain/Loss/LOH
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Chromosome Number | Gain/Loss/Amp/LOH | Region |
---|---|---|
EXAMPLE 8 | EXAMPLE Gain | EXAMPLE chr8:0-1000000 |
EXAMPLE 7 | EXAMPLE Loss | EXAMPLE chr7:0-1000000 |
Additional Description:
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Gene Mutations (SNV/INDEL)
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Gene | Mutation | Oncogene/Tumor Suppressor/Other | Presumed Mechanism (LOF/GOF/Other; Driver/Passenger) | Prevalence (COSMIC/TCGA/Other) |
---|---|---|---|---|
TP53 | R273H | Tumor Suppressor | LOF | 20% |
Additional Description:
- Other Mutations
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- Concomitant Mutations
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- Secondary Mutations
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- Mutually Exclusive
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Epigenomics (Methylation)
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Genes and Main Pathways Involved
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Diagnostic Testing Methods
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Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications)
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Familial Forms
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Other Information
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Links
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References
EXAMPLE Book
- Arber DA, Brunning RD, Le Beau MM, Falini B, Vardiman JW, Porwit A, Thiele J, Bloomfield CD (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4thedition.Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.
EXAMPLE Journal Article
- Li Y, Mehta PK, Nizetic D, Kaneko Y, Chan GCF, Chan LC, Squire J, Scherer SW and Hitzler JK (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.
Notes
*Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.