Testingnew move2

Myeloid proliferations and neoplasms (Overview Page Link)

Myeloid precursor lesions

 Clonal Haematopoiesis
   - Clonal haematopoiesis
   - Clonal cytopenias of undetermined significance

Myeloproliferative neoplasms

 Myeloproliferative neoplasms
   - Chronic myeloid leukaemia
   - Chronic neutrophilic leukaemia
   - Chronic eosinophilic leukaemia
   - Polycythaemia vera
   - Essential thrombocythaemia
   - Primary myelofibrosis
   - Juvenile myelomonocytic leukaemia
   - Myeloproliferative neoplasm, NOS

Mastocytosis

   - Cutaneous mastocytosis
   - Systemic mastocytosis
   - Mast cell sarcoma

Myelodysplastic neoplasms

 Myelodysplastic neoplasms, with defining genetic abnormalities
   - Myelodysplastic neoplasm with low blasts and 5q deletion
   - Myelodysplastic neoplasm with low blasts and SF3B1 mutation
   - Myelodysplastic neoplasm with biallelic TP53 inactivation
 Myelodysplastic neoplasms, morphologically defined
   - Myelodysplastic neoplasm with low blasts
   - Myelodysplastic neoplasm, hypoplastic
   - Myelodysplastic neoplasm with increased blasts
 Myelodysplastic neoplasms of childhood
   - Childhood myelodysplastic neoplasm with low blasts
   - Childhood myelodysplastic neoplasm with increased blasts

Myelodysplastic/myeloproliferative neoplasms

   - Chronic myelomonocytic leukaemia
   - Myelodysplastic/myeloproliferative neoplasm with neutrophilia
   - Myelodysplastic/myeloproliferative neoplasm with SF3B1 mutation and thrombocytosis
   - Myelodysplastic/myeloproliferative neoplasm, NOS

Acute myeloid leukaemia

 Acute myeloid leukaemia with defining genetic abnormalities
   - Acute promyelocytic leukaemia with PML::RARA fusion
   - Acute myeloid leukaemia with RUNX1::RUNX1T1 fusion
   - Acute myeloid leukaemia with CBFB::MYH11 fusion
   - Acute myeloid leukaemia with DEK::NUP214 fusion
   - Acute myeloid leukaemia with RBM15::MRTFA fusion
   - Acute myeloid leukaemia with BCR::ABL1 fusion
   - Acute myeloid leukaemia with KMT2A rearrangement
   - Acute myeloid leukaemia with MECOM rearrangement
   - Acute myeloid leukaemia with NUP98 rearrangement
   - Acute myeloid leukaemia with NPM1 mutation
   - Acute myeloid leukaemia with CEBPA mutation
   - Acute myeloid leukaemia, myelodysplasia-related
   - Acute myeloid leukaemia with other defined genetic alterations
 Acute myeloid leukaemia, defined by differentiation
   - Acute myeloid leukaemia with minimal differentiation
   - Acute myeloid leukaemia without maturation
   - Acute myeloid leukaemia with maturation
   - Acute basophilic leukaemia
   - Acute myelomonocytic leukaemia
   - Acute monocytic leukaemia
   - Acute erythroid leukaemia
   - Acute megakaryoblastic leukaemia
 Myeloid sarcoma
   - Myeloid sarcoma

Myeloid neoplasms, secondary

 Myeloid neoplasms and proliferations associated with antecedent or predisposing conditions
   - Myeloid neoplasm post cytotoxic therapy
   - Myeloid neoplasms associated with germline predisposition
   - Myeloid proliferations associated with Down syndrome

Myeloid/lymphoid neoplasms

 Myeloid/lymphoid neoplasms with eosinophilia and defining gene rearrangement
   - Myeloid/lymphoid neoplasm with PDGFRA rearrangement
   - Myeloid/lymphoid neoplasm with PDGFRB rearrangement
   - Myeloid/lymphoid neoplasm with FGFR1 rearrangement
   - Myeloid/lymphoid neoplasm with JAK2 rearrangement
   - Myeloid/lymphoid neoplasm with FLT3 rearrangement
   - Myeloid/lymphoid neoplasm with ETV6::ABL1 fusion
   - Myeloid/lymphoid neoplasms with other tyrosine kinase fusion genes

Acute leukaemias of mixed or ambiguous lineage

 Acute leukaemia of ambiguous lineage with defining genetic abnormalities
   - Mixed-phenotype acute leukaemia with BCR::ABL1 fusion
   - Mixed-phenotype acute leukaemia with KMT2A rearrangement
   - Acute leukaemia of ambiguous lineage with other defined genetic alterations 
 Acute leukaemia of ambiguous lineage, immunophenotypically defined
   - Mixed-phenotype acute leukaemia, B/myeloid
   - Mixed-phenotype acute leukaemia, T/myeloid
   - Mixed-phenotype acute leukaemia, rare types
   - Acute leukaemia of ambiguous lineage, NOS
   - Acute undifferentiated leukaemia

Histiocytic/Dendritic cell neoplasms (Overview Page Link)

Plasmacytoid dendritic cell neoplasms

 Plasmacytoid dendritic cell neoplasms
   - Mature plasmacytoid dendritic cell proliferation associated with myeloid neoplasm
   - Blastic plasmacytoid dendritic cell neoplasm

Langerhans cell and other dendritic cell neoplasms

 Langerhans cells neoplasms
   - Langerhans cell histiocytosis
   - Langerhans cell sarcoma
 Other dendritic cell neoplasms
   - Indeterminate dendritic cell tumour
   - Interdigitating dendritic cell sarcoma

Histiocyte/macrophage neoplasms

 Histiocytic neoplasms
   - Juvenile xanthogranuloma
   - Erdheim-Chester disease
   - Rosai-Dorfman Disease
   - ALK-positive histiocytosis
   - Histiocytic sarcoma

B-cell lymphoid proliferations and lymphomas (Overview Page Link)

Tumour like lesions with B-cell predominance

   - Reactive B-cell rich lymphoid proliferations that can mimic lymphoma
   - IgG4-related disease
   - Unicentric Castleman disease
   - Idiopathic multicentric Castleman disease
   - KSHV/HHV8-associated multicentric Castleman disease

Precursor B-cell neoplasms

 B-lymphoblastic leukaemias/lymphomas
   - B-lymphoblastic leukaemia/lymphoma
   - B-lymphoblastic leukaemia/lymphoma with high hyperdiploidy
   - B-lymphoblastic leukaemia/lymphoma with hypodiploidy
   - B-lymphoblastic leukaemia/lymphoma with iAMP21
   - B-lymphoblastic leukaemia/lymphoma with BCR::ABL1 fusion
   - B-lymphoblastic leukaemia/lymphoma with BCR::ABL1-like features
   - B lymphoblastic leukaemia/lymphoma with KMT2A rearrangement
   - B lymphoblastic leukaemia/lymphoma with ETV6::RUNX1 fusion
   - B-lymphoblastic leukaemia/lymphoma with ETV6::RUNX1-like features
   - B lymphoblastic leukaemia/lymphoma with TCF3::PBX1 fusion
   - B lymphoblastic leukaemia/lymphoma with IGH::IL3 fusion 
   - B lymphoblastic leukaemia/lymphoma with TCF3::HLF fusion
   - B-lymphoblastic leukaemia/lymphoma with other defined genetic alterations
   - B-lymphoblastic leukaemia/lymphoma, NOS

Mature B-cell neoplasms

 Pre-neoplastic and neoplastic small lymphocytic proliferations 
   - Monoclonal B-cell lymphocytosis
   - Chronic lymphocytic leukaemia/small lymphocytic lymphoma
 Splenic B-cell lymphomas and leukaemias
   - Hairy cell leukaemia
   - Splenic marginal zone lymphoma
   - Splenic diffuse red pulp small B-cell lymphoma
   - Splenic B-cell lymphoma/leukaemia with prominent nucleoli
 Lymphoplasmacytic lymphoma
   - Lymphoplasmacytic lymphoma
 Marginal zone lymphoma
   - Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue
   - Primary cutaneous marginal zone lymphoma 
   - Nodal marginal zone lymphoma
   - Paediatric nodal marginal zone lymphoma
 Follicular lymphoma
   - In situ follicular B-cell neoplasm
   - Follicular lymphoma
   - Paediatric-type follicular lymphoma
   - Duodenal-type follicular lymphoma
 Cutaneous follicle centre lymphoma
   - Primary cutaneous follicle centre lymphoma
 Mantle cell lymphoma
   - In situ mantle cell neoplasm
   - Mantle cell lymphoma
   - Leukaemic non-nodal mantle cell lymphoma
 Transformations of indolent B-cell lymphomas
   - Transformations of indolent B-cell lymphomas
 Large B-cell lymphomas
   - Diffuse large B-cell lymphoma, NOS
   - T-cell/histiocyte-rich large B-cell lymphoma
   - Diffuse large B-cell lymphoma / high grade B-cell lymphoma with MYC and BCL2 rearrangements
   - ALK-positive large B-cell lymphoma
   - Large B-cell lymphoma with IRF4 rearrangement
   - High grade B-cell lymphoma with 11q aberrations
   - Lymphomatoid granulomatosis
   - EBV-positive diffuse large B-cell lymphoma
   - Diffuse large B-cell lymphoma associated with chronic inflammation
   - Fibrin-associated large B-cell lymphoma
   - Fluid overload-associated large B-cell lymphoma
   - Plasmablastic lymphoma
   - Primary large B-cell lymphoma of immune-privileged sites
   - Primary cutaneous diffuse large B-cell lymphoma, leg type
   - Intravascular large B-cell lymphoma
   - Primary mediastinal large B-cell lymphoma
   - Mediastinal grey zone lymphoma
   - High-grade B-cell lymphoma, NOS
 Burkitt lymphoma
   - Burkitt lymphoma
 KSHV/HHV8-associated B-cell lymphoid proliferations and lymphomas
   - Primary effusion lymphoma
   - KSHV/HHV8-positive diffuse large B-cell lymphoma
   - KSHV/HHV8-positive germinotropic lymphoproliferative disorder
 Lymphoid proliferations and lymphomas associated with immune deficiency and dysregulation
   - Hyperplasias arising in immune deficiency/dysregulation
   - Polymorphic lymphoproliferative disorders arising in immune deficiency / dysregulation 
   - EBV-positive mucocutaneous ulcer
   - Lymphomas arising in immune deficiency / dysregulation 
   - Inborn error of immunity-associated lymphoid proliferations and lymphomas

Hodgkin lymphoma

   - Classic Hodgkin lymphoma 
   - Nodular lymphocyte predominant Hodgkin lymphoma

Plasma cell neoplasms and other diseases with paraproteins

 Monoclonal gammopathies
   - Cold agglutinin disease 
   - IgM monoclonal gammopathy of undetermined significance
   - Non-IgM monoclonal gammopathy of undetermined significance
   - Monoclonal gammopathy of renal significance
 Diseases with monoclonal immunoglobulin deposition
   - Immunoglobulin-related (AL) amyloidosis
   - Monoclonal immunoglobulin deposition disease
 Heavy chain diseases
   - Mu heavy chain disease
   - Gamma heavy chain disease
   - Alpha heavy chain disease
 Plasma cell neoplasms
   - Plasmacytoma
   - Plasma cell myeloma / multiple myeloma
   - Plasma cell neoplasms with associated paraneoplastic syndrome

T-cell and NK-cell lymphoid proliferations and lymphomas (Overview Page Link)

Tumour-like lesions with T-cell predominance

   - Kikuchi-Fujimoto disease
   - Autoimmune lymphoproliferative syndrome
   - Indolent T-lymphoblastic proliferation

Precursor T-cell neoplasms

 T-lymphoblastic leukaemia / lymphoma
   - T-lymphoblastic leukaemia / lymphoma, NOS
   - Early T-precursor lymphoblastic leukaemia / lymphoma 

Mature T-cell and NK-cell neoplasms

 Mature T-cell and NK-cell leukaemias
   - T-prolymphocytic leukaemia
   - T-large granular lymphocytic leukaemia
   - NK-large granular lymphocytic leukaemia
   - Adult T-cell leukaemia/lymphoma
   - Sezary syndrome
   - Aggressive NK-cell leukaemia
 Primary cutaneous T-cell lymphoid proliferations and lymphomas
   - Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder
   - Primary cutaneous acral CD8-positive T-cell lymphoproliferative disorder
   - Mycosis fungoides
   - Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Lymphomatoid papulosis
   - Primary cutaneous CD30-positive T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma
   - Subcutaneous panniculitis-like T-cell lymphoma
   - Primary cutaneous gamma/delta T-cell lymphoma
   - Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma
   - Primary cutaneous peripheral T-cell lymphoma, NOS
 Intestinal T-cell and NK-cell lymphoid proliferations and lymphomas
   - Indolent T-cell lymphoma of the gastrointestinal tract
   - Indolent NK-cell lymphoproliferative disorder of the gastrointestinal tract
   - Enteropathy-associated T-cell lymphoma
   - Monomorphic epitheliotropic intestinal T-cell lymphoma
   - Intestinal T-cell lymphoma, NOS
 Hepatosplenic T-cell lymphoma
   - Hepatosplenic T-cell lymphoma
 Anaplastic large cell lymphoma
   - ALK-positive anaplastic large cell lymphoma
   - ALK-negative anaplastic large cell lymphoma
   - Breast implant-associated anaplastic large cell lymphoma
 Nodal T-follicular helper (TFH) cell lymphoma
   - Nodal TFH cell lymphoma, angioimmunoblastic-type
   - Nodal TFH cell lymphoma, follicular-type
   - Nodal TFH cell lymphoma, NOS
 Other peripheral T-cell lymphomas
   - Peripheral T-cell lymphoma, NOS
 EBV-positive NK-cell and T-cell lymphomas
   - EBV-positive nodal T- and NK-cell lymphoma
   - Extranodal NK/T-cell lymphoma
 EBV-positive T-cell and NK-cell lymphoid proliferations and lymphomas of childhood
   - Severe mosquito bite allergy
   - Hydroa vacciniforme lymphoproliferative disorder
   - Systemic chronic active EBV disease
   - Systemic EBV-positive T-cell lymphoma of childhood

Stroma-derived neoplasms of lymphoid tissues (Overview Page Link)

Mesenchymal dendritic cell neoplasms

 Follicular dendritic cell neoplasms
   - Follicular dendritic cell sarcoma
   - EBV-positive inflammatory follicular dendritic cell sarcoma
   - Fibroblastic reticular cell tumour

Myofibroblastic tumours

 Myofibroblastic tumour
   - Intranodal palisaded myofibroblastoma

Spleen-specific vascular-stromal tumours

 Splenic vascular-stromal tumours
   - Littoral cell angioma
   - Splenic hamartoma
   - Sclerosing angiomatoid nodular transformation (SANT) of spleen

Genetic tumour syndromes (Overview Page Link)

   - Fanconi anaemia
   - Bloom syndrome
   - Ataxia-telangiectasia syndrome
   - RASopathies