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Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray (view source)
Revision as of 09:15, 17 November 2018
, 09:15, 17 November 2018no edit summary
|Activation of MYC pathway is often seen with loss of 9p (CDKN2A/B), and 14q (MAX gene) and is reported to have a worse prognosis
|Activation of MYC pathway is often seen with loss of 9p (CDKN2A/B), and 14q (MAX gene) and is reported to have a worse prognosis
|PMID:27090007; PMID:26061753; PMID:25263767 PMID:26061754; PMID:24335697; PMID:25664944;PMID:26061753; PMID:26941959; PMID:26824661 PMID:26061751
|PMID:27090007; PMID:26061753; PMID:25263767 PMID:26061754; PMID:24335697; PMID:25664944;PMID:26061753; PMID:26941959; PMID:26824661 PMID:26061751
|-
|Glioblastoma , grade IV, IDH mutant
|'''Gain:''' 1/1q, 6p<br>
'''Loss:''' 3p, 10, 13, 14, 15, 22 (3, 4q, 19q, 16p, 21q, 5p seen in age <40)<br>
'''Amplification:''' CDK6, cyclin E2, CDK4, MET<br>
'''Chromothripsis'''
|'''Gain or Amplification:''' CDK4, CDK6, cyclin E2<br>
'''Loss:''' PTEN
|About 10% of glioblastomas; correspond closely to secondary glioblastoma with history of prior glioma. These cases often involve loss of 10q , gain of CDK4, CDK6, cyclin E2, and increase in copy number alterations.
|PMID:26061754; PMID:25754088; PMID:28535583 PMID:25931051; PMID:26091668; PMID:25461780; PMID:27157931; PMID:25727226; PMID:26323991 PMID:26061751; PMID:29687258
|-
|
|Glioblastoma , grade IV, IDH wildtype
|'''Loss:''' 4, 9p, 10, 13, 14, 15, 22 , (3, 4q, 19q, 16p, 21q, 5p loss in age <40)<br>
'''Gain:''' 7, 19, 20 (1q, 12p, 11q, 9q, 4, 10p gain in age <40) <br>
'''Amplification:''' EGFR, MDM4, CDK4, MET
|'''Loss:''' homozygous CDKN2A/B, PTEN, RB1<br>
'''Mutation:''' TERT, EGFR, PTEN, NF1, RB1, PIK3CA or PIK3R1, TP53<br>
'''Amplification:''' EGFR, MDM4, MDM2, CDK4, PDGFRA, MET
|Overall poor prognosis. Gain of 19q, amplification of EGFR, and homozygous loss of CDKN2A are seen primarily in patients over age 40. Co-gain of 19 and 20 may be associated with longer survival.
|PMID:26061754; PMID:25754088; PMID:28535583 PMID:25931051; PMID:26091668; PMID:25461780; PMID:27157931; PMID:25727226; PMID:26061751
|-
|'''MENINGIOMA'''
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|Grade 1
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