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Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray (view source)
Revision as of 08:59, 17 November 2018
, 08:59, 17 November 2018no edit summary
{| class="wikitable"
{| class="wikitable"
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! ADULT TUMOR
! TUMOR
! SUBTYPES
! SUBTYPES
! BROAD ABERRATIONS (>10Mb)
! BROAD ABERRATIONS (>10Mb)
|Adults and pediatric tumors show similar CNVs; CDKN2A/CDKN2B loss may correlate with anaplastic histology
|Adults and pediatric tumors show similar CNVs; CDKN2A/CDKN2B loss may correlate with anaplastic histology
|PMID:23442159; PMID:28181325
|PMID:23442159; PMID:28181325
|-
|
|Ganglioglioma
|'''Gain:''' polysomy 5, polysomy 7, 10p<br>
'''Loss:''' 1p loss, monosomy (with focal CDKN2A loss)
|'''Mutation:''' BRAF V600E , TSC1, TSC2, FGFR1, FGFR2, KRAS
|Generally indolent tumors; surgical resection can be curative
|PMID:23442159; PMID:25764012; PMID:29880043
|-
|
|Angiocentric glioma
|'''Loss:''' 6q24-q25
|'''Fusion:''' MYB-QKI rearrangement/deletion (classic histology)<br>
'''Rearrangement:''' MYB alone (atypical histology)<br>
'''Amplification:''' MYB (atypical histology)
|Generally indolent tumors; surgical resection can be curative
|PMID:26829751
|-
|
|Dysembryoplastic neuroepithelial tumor (DNET)
|No specific changes
|'''Mutation:''' intragenic duplication or mutation FGFR1; BRAF V600E
|Rare in adults; Benign with excellent prognosis even with subtotal resection
|PMID:26920151; PMID:23442159; PMID:21937911
|-
|
|Rosette forming glioneuronal tumor
|'''Gain:'''1q , 7, 9, 16<br>
'''Loss:''' 1p<br>
'''Amplification:''' 9q34.2, 19p13.3
|'''Fusion:''' KIAA1549-BRAF fusion (via 3'BRAF duplication)<br>
'''Mutation:''' PIK3CA, FGFR1<br>
'''Amplification:''' SBNO2
|Generally indolent tumors; surgical resection can be curative
|PMID:27893178; PMID:26371886
|-
|Infiltrating Gliomas
|-