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Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray (view source)
Revision as of 14:10, 16 November 2018
, 14:10, 16 November 2018no edit summary
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|Low grade gliomas, WHO grade I-II
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|Pilocytic astrocytoma
|'''Gain:''' 5, 7, 6, 11<br>
'''Loss:''' 1, 2, 3, 13, 14, 16, 17, 19
|'''Fusion:''' KIAA1549-BRAF fusion (via 3'BRAF duplication), other BRAF partners reported; NTRK fusions (rare)<br>
'''Mutation:''' FGFR1
|Aneuploidy is more predominant in adult PA; Infratentorial tumors are more likely to have BRAF fusions/dup and be wildtype for BRAF mutations; Extra-cerebellar tumors are more likely to be BRAF V600E+, but negative for fusion; Surgical resection can be curative
|PMID: 24470550; PMID:26378811; PMID: 25664944; PMID:26992069
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|Pleomorphic xanthoastrocytoma (PXA)
|'''Gain:''' 7, 2, 5, 21, 20, 12, 15<br>
'''Loss:''' monosomy 9 / 9p deletion most common, 22, 14, 13, 10<br>
'''CN-LOH:''' 9p, 22
|'''Loss:''' homozygous loss CDKN2A/B<br>
Mutation: BRAF V600E
|Adults and pediatric tumors show similar CNVs; CDKN2A/CDKN2B loss may correlate with anaplastic histology
|PMID:23442159; PMID:28181325