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HAEM5:Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder (view source)
Revision as of 13:17, 11 June 2024
, 11 June→Immunophenotype
Solitary skin nodule/papule/plaque<ref name=":1" /><ref name=":0" />
Solitary skin nodule/papule/plaque<ref name=":1" /><ref name=":0" />
Multiple lesions in a small number of patients<ref name=":1" /><ref name=":0" />
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|'''Laboratory Findings'''
|'''Laboratory Findings'''
==Morphologic Features==
==Morphologic Features==
* Dense dermal lymphoid infiltrate, often with nodular or diffuse pattern
*Dense dermal lymphoid infiltrate, often with nodular or diffuse pattern<ref name=":2">{{Cite journal|last=Beltraminelli|first=Helmut|last2=Leinweber|first2=Bernd|last3=Kerl|first3=Helmut|last4=Cerroni|first4=Lorenzo|date=2009-06|title=Primary cutaneous CD4+ small-/medium-sized pleomorphic T-cell lymphoma: a cutaneous nodular proliferation of pleomorphic T lymphocytes of undetermined significance? A study of 136 cases|url=https://pubmed.ncbi.nlm.nih.gov/19461234|journal=The American Journal of Dermatopathology|volume=31|issue=4|pages=317–322|doi=10.1097/DAD.0b013e31819f19bb|issn=1533-0311|pmid=19461234}}</ref><ref name=":3">{{Cite journal|last=Cetinözman|first=Fatma|last2=Jansen|first2=Patty M.|last3=Willemze|first3=Rein|date=2012-01|title=Expression of programmed death-1 in primary cutaneous CD4-positive small/medium-sized pleomorphic T-cell lymphoma, cutaneous pseudo-T-cell lymphoma, and other types of cutaneous T-cell lymphoma|url=https://pubmed.ncbi.nlm.nih.gov/21989349|journal=The American Journal of Surgical Pathology|volume=36|issue=1|pages=109–116|doi=10.1097/PAS.0b013e318230df87|issn=1532-0979|pmid=21989349}}</ref>
* Tends to extend to subcutaneous tissue
*Tends to extend to subcutaneous tissue<ref name=":3" /><ref name=":2" />
* Lack significant epidermotropism
*Lack significant epidermotropism and folliculotropism<ref name=":3" />
* Predominantly small/medium-size T-cells with pleomorphism
*Predominantly small/medium-size T-cells with pleomorphism<ref name=":3" /><ref name=":2" /><ref name=":1" /><ref name=":0" />
* Low number of large lymphocytes allow (<30%)
*Low number of large lymphocytes allowed (<30%)<ref name=":0" /><ref name=":2" /><ref name=":3" />
* Often mixed background of CD8+ T-cells, B-cells plasma cells, histiocytes, +/-multinucleated giant cells<br />
*Often mixed background containing CD8+ T-cells, B-cells, plasma cells, histiocytes, +/-multinucleated giant cells or granulomatous change<ref name=":3" /><ref name=":2" />
*Absent/few eosinophils<ref name=":3" /><br />
==Immunophenotype==
==Immunophenotype==