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| {| class="wikitable" | | {| class="wikitable" |
| |'''Signs and Symptoms''' | | |'''Signs and Symptoms''' |
− | |<span class="blue-text">EXAMPLE:</span> Asymptomatic (incidental finding on complete blood counts) | + | |Asymptomatic |
− | <span class="blue-text">EXAMPLE:</span> B-symptoms (weight loss, fever, night sweats)
| + | Slow growing |
| | | |
− | <span class="blue-text">EXAMPLE:</span> Lymphadenopathy (uncommon) | + | Solitary skin nodule/papule/plaque<ref name=":1" /><ref name=":0" /> |
| |- | | |- |
| |'''Laboratory Findings''' | | |'''Laboratory Findings''' |
− | |<span class="blue-text">EXAMPLE:</span> Cytopenias | + | |N/A |
− | <span class="blue-text">EXAMPLE:</span> Lymphocytosis (low level)
| |
| |} | | |} |
| ==Sites of Involvement== | | ==Sites of Involvement== |
− | Skin, commonly involving head and neck region and upper body. <ref>{{Cite journal|last=Surmanowicz|first=Philip|last2=Doherty|first2=Sean|last3=Sivanand|first3=Arunima|last4=Parvinnejad|first4=Nikoo|last5=Deschenes|first5=Jean|last6=Schneider|first6=Michelle|last7=Hardin|first7=Jori|last8=Gniadecki|first8=Robert|date=2020-12-16|title=The Clinical Spectrum of Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferative Disorder: An Updated Systematic Literature Review and Case Series|url=https://doi.org/10.1159/000511473|journal=Dermatology|volume=237|issue=4|pages=618–628|doi=10.1159/000511473|issn=1018-8665}}</ref> | + | Skin, commonly involving head and neck region and upper body. <ref name=":1">{{Cite journal|last=Surmanowicz|first=Philip|last2=Doherty|first2=Sean|last3=Sivanand|first3=Arunima|last4=Parvinnejad|first4=Nikoo|last5=Deschenes|first5=Jean|last6=Schneider|first6=Michelle|last7=Hardin|first7=Jori|last8=Gniadecki|first8=Robert|date=2020-12-16|title=The Clinical Spectrum of Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferative Disorder: An Updated Systematic Literature Review and Case Series|url=https://doi.org/10.1159/000511473|journal=Dermatology|volume=237|issue=4|pages=618–628|doi=10.1159/000511473|issn=1018-8665}}</ref> |
| ==Morphologic Features== | | ==Morphologic Features== |
− | <br /> | + | |
| + | * Dense dermal lymphoid infiltrate, often with nodular or diffuse pattern |
| + | * Tends to extend to subcutaneous tissue |
| + | * Lack significant epidermotropism |
| + | * Predominantly small/medium-size T-cells with pleomorphism |
| + | * Low number of large lymphocytes allow (<30%) |
| + | * Often mixed background of CD8+ T-cells, B-cells plasma cells, histiocytes, +/-multinucleated giant cells<br /> |
| + | |
| ==Immunophenotype== | | ==Immunophenotype== |
| Put your text here and fill in the table <span style="color:#0070C0">(''Instruction: Can include references in the table. Do not delete table.'') </span> | | Put your text here and fill in the table <span style="color:#0070C0">(''Instruction: Can include references in the table. Do not delete table.'') </span> |