Difference between revisions of "MECOM"
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Brian Davis, PhD | Brian Davis, PhD | ||
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| + | UNDER REVIEW 4/30/19 | ||
__TOC__ | __TOC__ | ||
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==Genomic Location== | ==Genomic Location== | ||
| − | '''Cytoband:''' | + | '''Cytoband:''' 3q26.2 (from GeneCards) |
'''Genomic Coordinates:''' | '''Genomic Coordinates:''' | ||
| − | + | chr3:169,083,499-169,663,786(GRCh38/hg38) (from GeneCards) | |
| − | |||
| − | |||
| − | + | chr3:168,801,287-169,381,563(GRCh37/hg19) (from GeneCards) | |
==Cancer Category/Type== | ==Cancer Category/Type== | ||
| Line 37: | Line 37: | ||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
|- | |- | ||
| − | ! Copy Number Loss | + | !Copy Number Loss!!Copy Number Gain!!LOH!!Loss-of-Function Mutation!!Gain-of-Function Mutation!!Translocation/Fusion |
|- | |- | ||
| − | | EXAMPLE: X ||EXAMPLE: X | + | |EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X |
|} | |} | ||
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'''[http://www.omim.org/entry/165215 ''MECOM'' by OMIM]''' - compendium of human genes and genetic phenotypes | '''[http://www.omim.org/entry/165215 ''MECOM'' by OMIM]''' - compendium of human genes and genetic phenotypes | ||
| − | '''[https://databases.lovd.nl/shared/genes/MECOM | + | '''[https://databases.lovd.nl/shared/genes/MECOM ''MECOM'' by LOVD(3)]''' - Leiden Open Variation Database |
'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=MECOM ''MECOM'' by TICdb]''' - database of Translocation breakpoints In Cancer | '''[http://www.unav.es/genetica/TICdb/results.php?hgnc=MECOM ''MECOM'' by TICdb]''' - database of Translocation breakpoints In Cancer | ||
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==References== | ==References== | ||
| − | === EXAMPLE Book === | + | ===EXAMPLE Book=== |
| + | |||
#Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118. | #Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118. | ||
| − | === EXAMPLE Journal Article === | + | ===EXAMPLE Journal Article=== |
| + | |||
#Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691. | #Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691. | ||
| − | == Notes == | + | ==Notes== |
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome. | <nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome. | ||
[[Category:Cancer Genes M]] | [[Category:Cancer Genes M]] | ||
Latest revision as of 16:13, 30 April 2019
Primary Author(s)*
Brian Davis, PhD
UNDER REVIEW 4/30/19
Synonyms
Put your text here
EXAMPLE: Tumor protein p53, LFS1, p53, BCC7, TRP53
Genomic Location
Cytoband: 3q26.2 (from GeneCards)
Genomic Coordinates:
chr3:169,083,499-169,663,786(GRCh38/hg38) (from GeneCards)
chr3:168,801,287-169,381,563(GRCh37/hg19) (from GeneCards)
Cancer Category/Type
Put your text here
Gene Overview
Put your text here.
Common Alteration Types
Put your text here and/or fill in the table with an X where applicable
| Copy Number Loss | Copy Number Gain | LOH | Loss-of-Function Mutation | Gain-of-Function Mutation | Translocation/Fusion |
|---|---|---|---|---|---|
| EXAMPLE: X | EXAMPLE: X | EXAMPLE: X | EXAMPLE: X | EXAMPLE: X | EXAMPLE: X |
Internal Pages
Put your text here
EXAMPLE Germline Cancer Predisposition Genes
External Links
MECOM by Atlas of Genetics and Cytogenetics in Oncology and Haematology - detailed gene information
MECOM by COSMIC - sequence information, expression, catalogue of mutations
No Entry for MECOM at CIViC - general knowledge and evidence-based variant specific information
MECOM by St. Jude ProteinPaint mutational landscape and matched expression data.
MECOM by Precision Medicine Knowledgebase (Weill Cornell) - manually vetted interpretations of variants and CNVs
MECOM by Cancer Index - gene, pathway, publication information matched to cancer type
No Entry for MECOM at OncoKB - mutational landscape, mutation effect, variant classification
MECOM by NCBI Gene - brief gene overview
MECOM by My Cancer Genome - brief gene overview
MECOM by UniProt - protein and molecular structure and function
MECOM by Pfam - gene and protein structure and function information
MECOM by GeneCards - general gene information and summaries
MECOM by OMIM - compendium of human genes and genetic phenotypes
MECOM by LOVD(3) - Leiden Open Variation Database
MECOM by TICdb - database of Translocation breakpoints In Cancer
References
EXAMPLE Book
- Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.
EXAMPLE Journal Article
- Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.
Notes
*Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.