Difference between revisions of "MECOM"

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==Primary Author(s)*==
 
==Primary Author(s)*==
  
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Put your text here
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Brian Davis, PhD
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UNDER REVIEW 4/30/19
  
 
__TOC__
 
__TOC__
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==Genomic Location==
 
==Genomic Location==
  
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'''Cytoband:''' Put your text here. EXAMPLE: 17p13.1
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'''Cytoband:''' 3q26.2 (from GeneCards)
  
 
'''Genomic Coordinates:'''  
 
'''Genomic Coordinates:'''  
  
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Put your text here
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chr3:169,083,499-169,663,786(GRCh38/hg38) (from GeneCards)
  
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EXAMPLE: chr17:7,571,720-7,590,868 [hg19]
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chr3:168,801,287-169,381,563(GRCh37/hg19) (from GeneCards)
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EXAMPLE: chr17:7,668,402-7,687,538 [hg38]
 
  
 
==Cancer Category/Type==
 
==Cancer Category/Type==
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{| class="wikitable sortable"
 
{| class="wikitable sortable"
 
|-
 
|-
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! Copy Number Loss   !! Copy Number Gain   !! LOH   !!   Loss-of-Function Mutation   !! Gain-of-Function Mutation !! Translocation/Fusion  
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!Copy Number Loss!!Copy Number Gain!!LOH!!Loss-of-Function Mutation!!Gain-of-Function Mutation!!Translocation/Fusion
 
|-
 
|-
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| EXAMPLE: X ||EXAMPLE: X || EXAMPLE: X || EXAMPLE: X || EXAMPLE: X || EXAMPLE: X
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|EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X
 
|}
 
|}
  
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==External Links==
 
==External Links==
  
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Put your text here - Include as applicable links to: 1) Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2) COSMIC, 3) CIViC, 4) St. Jude ProteinPaint, 5) Precision Medicine Knnowledgebase (Weill Cornell), 6) Cancer Index, 7) OncoKB, 8) My Cancer Genome, 9) UniProt, 10) Pfam, 11) GeneCards, 12) GeneReviews, and 13) Any gene-specific databases.
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'''[http://atlasgeneticsoncology.org/Genes/EVI103q26ID19.html ''MECOM'' by Atlas of Genetics and Cytogenetics in Oncology and Haematology]''' - detailed gene information
  
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EXAMPLES
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'''[https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=MECOM ''MECOM'' by COSMIC]''' - sequence information, expression, catalogue of mutations
  
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'''[http://atlasgeneticsoncology.org/Genes/P53ID88.html ''TP53'' by Atlas of Genetics and Cytogenetics in Oncology and Haematology]''' - detailed gene information
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'''No Entry for MECOM at CIViC''' - general knowledge and evidence-based variant specific information
  
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'''[https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TP53 ''TP53'' by COSMIC]''' - sequence information, expression, catalogue of mutations
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'''[https://pecan.stjude.cloud/proteinpaint/MECOM ''MECOM'' by St. Jude ProteinPaint]''' mutational landscape and matched expression data.
  
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'''[https://civicdb.org/events/genes/45/summary/variants/1300/summary ''TP53'' by CIViC]''' - general knowledge and evidence-based variant specific information
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'''[https://pmkb.weill.cornell.edu/variants/2561 ''MECOM'' by Precision Medicine Knowledgebase (Weill Cornell)]''' - manually vetted interpretations of variants and CNVs
  
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'''[http://p53.iarc.fr/ ''TP53'' by IARC]''' - ''TP53'' database with reference sequences and mutational landscape
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'''[http://www.cancerindex.org/geneweb/EVI1.htm ''MECOM'' by Cancer Index]''' - gene, pathway, publication information matched to cancer type
  
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'''[https://pecan.stjude.cloud/proteinpaint/tp53 ''TP53'' by St. Jude ProteinPaint]''' mutational landscape and matched expression data.
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'''No Entry for MECOM at OncoKB''' - mutational landscape, mutation effect, variant classification
  
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'''[https://pmkb.weill.cornell.edu/search?utf8=%E2%9C%93&search=tp53 ''TP53'' by Precision Medicine Knowledgebase (Weill Cornell)]''' - manually vetted interpretations of variants and CNVs
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'''[https://www.ncbi.nlm.nih.gov/gene/2122 ''MECOM'' by NCBI Gene]''' - brief gene overview
  
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'''[http://www.cancerindex.org/geneweb/TP53.htm ''TP53'' by Cancer Index]''' - gene, pathway, publication information matched to cancer type
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'''[https://www.mycancergenome.org/content/gene/MECOM/ ''MECOM'' by My Cancer Genome]''' - brief gene overview
  
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'''[http://oncokb.org/#/gene/TP53 ''TP53'' by OncoKB]''' - mutational landscape, mutation effect, variant classification
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'''[https://www.uniprot.org/uniprot/Q03112 ''MECOM'' by UniProt]''' - protein and molecular structure and function
  
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'''[https://www.mycancergenome.org/content/gene/tp53/ ''TP53'' by My Cancer Genome]''' - brief gene overview
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'''[http://pfam.xfam.org/protein/Q03112 ''MECOM'' by Pfam]''' - gene and protein structure and function information
  
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'''[http://www.uniprot.org/uniprot/P04637 ''TP53'' by UniProt]''' - protein and molecular structure and function
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'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=MECOM ''MECOM'' by GeneCards]''' - general gene information and summaries
  
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'''[https://pfam.xfam.org/family/p53 ''TP53'' by Pfam]''' - gene and protein structure and function information
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'''[http://www.omim.org/entry/165215 ''MECOM'' by OMIM]''' - compendium of human genes and genetic phenotypes
  
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'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=tp53 ''TP53'' by GeneCards]''' - general gene information and summaries
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'''[https://databases.lovd.nl/shared/genes/MECOM ''MECOM'' by LOVD(3)]''' - Leiden Open Variation Database
  
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'''[https://www.ncbi.nlm.nih.gov/books/NBK1311/ GeneReviews]''' - information on Li Fraumeni Syndrome
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'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=MECOM ''MECOM'' by TICdb]''' - database of Translocation breakpoints In Cancer
  
 
==References==
 
==References==
  
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=== EXAMPLE Book ===
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===EXAMPLE Book===
 +
 
 
#Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.
 
#Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.
  
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=== EXAMPLE Journal Article ===
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===EXAMPLE Journal Article===
 +
 
 
#Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.
 
#Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.
  
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== Notes ==
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==Notes==
 
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.
 
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.
  
 
[[Category:Cancer Genes M]]
 
[[Category:Cancer Genes M]]

Latest revision as of 16:13, 30 April 2019

Primary Author(s)*

Brian Davis, PhD

UNDER REVIEW 4/30/19

Synonyms

Put your text here

EXAMPLE: Tumor protein p53, LFS1, p53, BCC7, TRP53

Genomic Location

Cytoband: 3q26.2 (from GeneCards)

Genomic Coordinates:

chr3:169,083,499-169,663,786(GRCh38/hg38) (from GeneCards)

chr3:168,801,287-169,381,563(GRCh37/hg19) (from GeneCards)

Cancer Category/Type

Put your text here

Gene Overview

Put your text here.

Common Alteration Types

Put your text here and/or fill in the table with an X where applicable

Copy Number Loss Copy Number Gain LOH Loss-of-Function Mutation Gain-of-Function Mutation Translocation/Fusion
EXAMPLE: X EXAMPLE: X EXAMPLE: X EXAMPLE: X EXAMPLE: X EXAMPLE: X

Internal Pages

Put your text here

EXAMPLE Germline Cancer Predisposition Genes

External Links

MECOM by Atlas of Genetics and Cytogenetics in Oncology and Haematology - detailed gene information

MECOM by COSMIC - sequence information, expression, catalogue of mutations

No Entry for MECOM at CIViC - general knowledge and evidence-based variant specific information

MECOM by St. Jude ProteinPaint mutational landscape and matched expression data.

MECOM by Precision Medicine Knowledgebase (Weill Cornell) - manually vetted interpretations of variants and CNVs

MECOM by Cancer Index - gene, pathway, publication information matched to cancer type

No Entry for MECOM at OncoKB - mutational landscape, mutation effect, variant classification

MECOM by NCBI Gene - brief gene overview

MECOM by My Cancer Genome - brief gene overview

MECOM by UniProt - protein and molecular structure and function

MECOM by Pfam - gene and protein structure and function information

MECOM by GeneCards - general gene information and summaries

MECOM by OMIM - compendium of human genes and genetic phenotypes

MECOM by LOVD(3) - Leiden Open Variation Database

MECOM by TICdb - database of Translocation breakpoints In Cancer

References

EXAMPLE Book

  1. Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.

EXAMPLE Journal Article

  1. Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.

Notes

*Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.

Retrieved from "https://ccga.io/index.php?title=MECOM&oldid=5444"