Difference between revisions of "IKZF1"

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(Created page with "== Contributors == Linda B. Baughn, PhD == Description == Deletion of IKZF1 is a predictor of poor outcome and high risk of relapse in pediatric acute lymphoblastic leukemia =...")
 
 
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== Contributors ==
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{{Under Construction}}
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Linda B. Baughn, PhD
 
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== Description ==
 
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Deletion of IKZF1 is a predictor of poor outcome and high risk of relapse in pediatric acute lymphoblastic leukemia
 
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== Tumor Types ==
 
  
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== Prevalence ==
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See '''[https://ccga.io/index.php/Author_Instructions ''Author Instructions'']''' and '''[https://ccga.io/index.php/How_to_Curate_a_Gene_Page ''How to Curate a Gene Page'']'''
  
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== Genes Involved ==
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==Primary Author(s)*==
  
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Linda B. Baughn, PhD, Mayo Clinic
  
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==Diagnostic Testing==
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__TOC__
  
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==Synonyms==
  
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Put your text here
 +
EXAMPLE: Tumor protein p53, 'LFS1, p53, BCC7, TRP53
  
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== Clinical Significance ==
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==Genomic Location==
  
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'''Cytoband:''' Put your text here. EXAMPLE: 17p13.1
  
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'''Genomic Coordinates:'''
  
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== Therapeutics ==
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Put your text here
  
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EXAMPLE: chr17:7,571,720-7,590,868 [hg19]
  
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EXAMPLE: chr17:7,668,402-7,687,538 [hg38]
  
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== Links ==
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==Cancer Category/Type==
  
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Put your text here
  
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== References ==
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==Gene Overview==
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Mullighan, Charles G., et al. "Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia." New England Journal of Medicine 360.5 (2009): 470-480.
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Deletion of IKZF1 is a predictor of poor outcome and high risk of relapse in pediatric acute lymphoblastic leukemia.<ref>{{Cite journal|last=Mullighan|first=Charles G.|last2=Su|first2=Xiaoping|last3=Zhang|first3=Jinghui|last4=Radtke|first4=Ina|last5=Phillips|first5=Letha A.A.|last6=Miller|first6=Christopher B.|last7=Ma|first7=Jing|last8=Liu|first8=Wei|last9=Cheng|first9=Cheng|date=2009-01-29|title=Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia|url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674612/|journal=The New England journal of medicine|volume=360|issue=5|pages=470–480|doi=10.1056/NEJMoa0808253|issn=0028-4793|pmc=2674612|pmid=19129520}}</ref>
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==Common Alteration Types==
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Put your text here and fill in the table with an X where applicable
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{| class="wikitable sortable"
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|-
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!Copy Number Loss!!Copy Number Gain!!LOH!!Loss-of-Function Mutation!!Gain-of-Function Mutation!!Translocation/Fusion
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|-
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|EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X||EXAMPLE: X
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|}
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 +
==Internal Pages==
 +
 
 +
Put your links here (use "Link" icon at top of page)
 +
 +
==External Links==
 +
 
 +
Put your text here - Include as applicable links to:
 +
1) Atlas of Genetics and Cytogenetics in Oncology and Haematology,
 +
2) COSMIC,
 +
3) CIViC,
 +
4) St. Jude ProteinPaint,
 +
5) Precision Medicine Knowledgebase (Weill Cornell),
 +
6) Cancer Index,
 +
7) OncoKB,
 +
8) NCBI Gene
 +
9) My Cancer Genome,
 +
10) UniProt,
 +
11) Pfam,
 +
12) GeneCards,
 +
13) OMIM
 +
14) LOVD(3) - Leiden Open Variation Database
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15) TICdb - database of Translocation breakpoints In Cancer
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16) GeneReviews, and
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17) Any gene-specific databases.
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 +
EXAMPLES (these may be filled in already)
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'''[http://atlasgeneticsoncology.org/Genes/P53ID88.html ''TP53'' by Atlas of Genetics and Cytogenetics in Oncology and Haematology]''' - detailed gene information
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'''[https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=TP53 ''TP53'' by COSMIC]''' - sequence information, expression, catalogue of mutations
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'''[https://civicdb.org/events/genes/45/summary/variants/1300/summary ''TP53'' by CIViC]''' - general knowledge and evidence-based variant specific information
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'''[http://p53.iarc.fr/ ''TP53'' by IARC]''' - ''TP53'' database with reference sequences and mutational landscape
 +
 
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'''[https://pecan.stjude.cloud/proteinpaint/tp53 ''TP53'' by St. Jude ProteinPaint]''' mutational landscape and matched expression data.
 +
 
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'''[https://pmkb.weill.cornell.edu/search?utf8=%E2%9C%93&search=tp53 ''TP53'' by Precision Medicine Knowledgebase (Weill Cornell)]''' - manually vetted interpretations of variants and CNVs
 +
 
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'''[http://www.cancerindex.org/geneweb/TP53.htm ''TP53'' by Cancer Index]''' - gene, pathway, publication information matched to cancer type
 +
 
 +
'''[http://oncokb.org/#/gene/TP53 ''TP53'' by OncoKB]''' - mutational landscape, mutation effect, variant classification
 +
 
 +
'''[https://www.ncbi.nlm.nih.gov/gene/2122 ''MECOM'' by NCBI Gene]''' - brief gene overview
 +
 
 +
'''[https://www.mycancergenome.org/content/gene/tp53/ ''TP53'' by My Cancer Genome]''' - brief gene overview
 +
 
 +
'''[http://www.uniprot.org/uniprot/P04637 ''TP53'' by UniProt]''' - protein and molecular structure and function
 +
 
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'''[https://pfam.xfam.org/family/p53 ''TP53'' by Pfam]''' - gene and protein structure and function information
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'''[http://www.genecards.org/cgi-bin/carddisp.pl?gene=tp53 ''TP53'' by GeneCards]''' - general gene information and summaries
 +
 
 +
'''[http://www.omim.org/entry/165215 ''MECOM'' by OMIM]''' - compendium of human genes and genetic phenotypes
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'''[https://databases.lovd.nl/shared/genes/MECOM ''MECOM'' by LOVD(3)]''' - Leiden Open Variation Database
 +
 
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'''[http://www.unav.es/genetica/TICdb/results.php?hgnc=MECOM ''MECOM'' by TICdb]''' - database of Translocation breakpoints In Cancer
 +
 
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'''[https://www.ncbi.nlm.nih.gov/books/NBK1311/ GeneReviews]''' - information on Li Fraumeni Syndrome
 +
 
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==References==
 +
(use "Cite" icon at top of page)
 +
<references />
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===EXAMPLE Book===
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#Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p129-171.
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===EXAMPLE Internet Resource===
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#author name(s).  Date (if possible). page title, website title, web address, and date accessed.
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#Cingam, S. R. and Koshy, N.V. (2017). Cancer, Leukemia, Promyelocytic, Acute (APL, APML). https://www.ncbi.nlm.nih.gov/books/NBK459352/ Accessed August 3, 2018.
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==Notes==
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<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.

Latest revision as of 17:04, 18 March 2021

See Author Instructions and How to Curate a Gene Page

Primary Author(s)*

Linda B. Baughn, PhD, Mayo Clinic

Synonyms

Put your text here EXAMPLE: Tumor protein p53, 'LFS1, p53, BCC7, TRP53

Genomic Location

Cytoband: Put your text here. EXAMPLE: 17p13.1

Genomic Coordinates:

Put your text here

EXAMPLE: chr17:7,571,720-7,590,868 [hg19]

EXAMPLE: chr17:7,668,402-7,687,538 [hg38]

Cancer Category/Type

Put your text here

Gene Overview

Deletion of IKZF1 is a predictor of poor outcome and high risk of relapse in pediatric acute lymphoblastic leukemia.[1]

Common Alteration Types

Put your text here and fill in the table with an X where applicable

Copy Number Loss Copy Number Gain LOH Loss-of-Function Mutation Gain-of-Function Mutation Translocation/Fusion
EXAMPLE: X EXAMPLE: X EXAMPLE: X EXAMPLE: X EXAMPLE: X EXAMPLE: X

Internal Pages

Put your links here (use "Link" icon at top of page)

External Links

Put your text here - Include as applicable links to: 1) Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2) COSMIC, 3) CIViC, 4) St. Jude ProteinPaint, 5) Precision Medicine Knowledgebase (Weill Cornell), 6) Cancer Index, 7) OncoKB, 8) NCBI Gene 9) My Cancer Genome, 10) UniProt, 11) Pfam, 12) GeneCards, 13) OMIM 14) LOVD(3) - Leiden Open Variation Database 15) TICdb - database of Translocation breakpoints In Cancer 16) GeneReviews, and 17) Any gene-specific databases.

EXAMPLES (these may be filled in already)

TP53 by Atlas of Genetics and Cytogenetics in Oncology and Haematology - detailed gene information

TP53 by COSMIC - sequence information, expression, catalogue of mutations

TP53 by CIViC - general knowledge and evidence-based variant specific information

TP53 by IARC - TP53 database with reference sequences and mutational landscape

TP53 by St. Jude ProteinPaint mutational landscape and matched expression data.

TP53 by Precision Medicine Knowledgebase (Weill Cornell) - manually vetted interpretations of variants and CNVs

TP53 by Cancer Index - gene, pathway, publication information matched to cancer type

TP53 by OncoKB - mutational landscape, mutation effect, variant classification

MECOM by NCBI Gene - brief gene overview

TP53 by My Cancer Genome - brief gene overview

TP53 by UniProt - protein and molecular structure and function

TP53 by Pfam - gene and protein structure and function information

TP53 by GeneCards - general gene information and summaries

MECOM by OMIM - compendium of human genes and genetic phenotypes

MECOM by LOVD(3) - Leiden Open Variation Database

MECOM by TICdb - database of Translocation breakpoints In Cancer

GeneReviews - information on Li Fraumeni Syndrome

References

(use "Cite" icon at top of page)

  1. ↑ Mullighan, Charles G.; et al. (2009-01-29). "Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia". The New England journal of medicine. 360 (5): 470–480. doi:10.1056/NEJMoa0808253. ISSN 0028-4793. PMC 2674612. PMID 19129520.

EXAMPLE Book

  1. Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p129-171.

EXAMPLE Internet Resource

  1. author name(s). Date (if possible). page title, website title, web address, and date accessed.
  2. Cingam, S. R. and Koshy, N.V. (2017). Cancer, Leukemia, Promyelocytic, Acute (APL, APML). https://www.ncbi.nlm.nih.gov/books/NBK459352/ Accessed August 3, 2018.

Notes

*Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.

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