Difference between revisions of "HAEM5:Hairy cell leukaemia"
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{{DISPLAYTITLE:Hairy cell leukaemia}} | {{DISPLAYTITLE:Hairy cell leukaemia}} | ||
− | [[HAEM5:Table_of_Contents|Haematolymphoid Tumours (5th ed.)]] | + | |
+ | [[HAEM5:Table_of_Contents|Haematolymphoid Tumours (WHO Classification, 5th ed.)]] | ||
{{Under Construction}} | {{Under Construction}} | ||
− | <blockquote class= | + | <blockquote class="blockedit">{{Box-round|title=Content Update To WHO 5th Edition Classification Is In Process; Content Below is Based on WHO 4th Edition Classification|This page was converted to the new template on 2023-12-07. The original page can be found at [[HAEM4:Hairy Cell Leukemia]]. |
}}</blockquote> | }}</blockquote> | ||
− | <span style="color:#0070C0">(General Instructions – The main focus of these pages is the clinically significant genetic alterations in each disease type. Use [https://www.genenames.org/ <u>HUGO-approved gene names and symbols</u>] (italicized when appropriate), [https://varnomen.hgvs.org/ HGVS-based nomenclature for variants], as well as generic names of drugs and testing platforms or assays if applicable. Please complete tables whenever possible and do not delete them (add N/A if not applicable in the table and delete the examples). Please do not delete or alter the section headings. The use of bullet points alongside short blocks of text rather than only large paragraphs is encouraged. Additional instructions below in italicized blue text should not be included in the final page content. Please also see </span><u>[[Author_Instructions]]</u><span style="color:#0070C0"> and [[Frequently Asked Questions (FAQs)|<u>FAQs</u>]] as well as contact your [[Leadership|<u>Associate Editor</u>]] or [mailto:CCGA@cancergenomics.org <u>Technical Support</u>])</span> | + | <span style="color:#0070C0">(General Instructions – The main focus of these pages is the clinically significant genetic alterations in each disease type. Use [https://www.genenames.org/ <u>HUGO-approved gene names and symbols</u>] (italicized when appropriate), [https://varnomen.hgvs.org/ HGVS-based nomenclature for variants], as well as generic names of drugs and testing platforms or assays if applicable. Please complete tables whenever possible and do not delete them (add N/A if not applicable in the table and delete the examples); to add (or move) a row or column to a table, click within the table and select the > symbol that appears to be given options. Please do not delete or alter the section headings. The use of bullet points alongside short blocks of text rather than only large paragraphs is encouraged. Additional instructions below in italicized blue text should not be included in the final page content. Please also see </span><u>[[Author_Instructions]]</u><span style="color:#0070C0"> and [[Frequently Asked Questions (FAQs)|<u>FAQs</u>]] as well as contact your [[Leadership|<u>Associate Editor</u>]] or [mailto:CCGA@cancergenomics.org <u>Technical Support</u>])</span> |
==Primary Author(s)*== | ==Primary Author(s)*== | ||
− | * | + | *Michael Lack, DO, Shivani Golem, PhD FACMG |
__TOC__ | __TOC__ | ||
− | == | + | ==WHO Classification of Disease== |
− | + | {| class="wikitable" | |
− | + | !Structure | |
− | + | !Disease | |
− | + | |- | |
− | + | |Book | |
+ | |Haematolymphoid Tumours (5th ed.) | ||
+ | |- | ||
+ | |Category | ||
+ | |B-cell lymphoid proliferations and lymphomas | ||
+ | |- | ||
+ | |Family | ||
+ | |Mature B-cell neoplasms | ||
+ | |- | ||
+ | |Type | ||
+ | |Splenic B-cell lymphomas and leukaemias | ||
+ | |- | ||
+ | |Subtype(s) | ||
+ | |Hairy cell leukaemia | ||
+ | |} | ||
==Definition / Description of Disease== | ==Definition / Description of Disease== | ||
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*Incidence (age adjusted) ~ 0.3/100,000 | *Incidence (age adjusted) ~ 0.3/100,000 | ||
*2% of lymphoid leukemias | *2% of lymphoid leukemias | ||
− | *Median age: | + | *Median age: 58 years, rarely in patients in their 20s |
− | *Males:Females: 4 | + | *Males:Females: 4:1 |
*Whites >> Blacks | *Whites >> Blacks | ||
*78% to 92% 5yr survival | *78% to 92% 5yr survival | ||
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− | <blockquote class= | + | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":1" /><ref>{{Cite journal|last=Lr|first=Teras|last2=Ce|first2=DeSantis|last3=Jr|first3=Cerhan|last4=Lm|first4=Morton|last5=A|first5=Jemal|last6=Cr|first6=Flowers|date=2016|title=2016 US Lymphoid Malignancy Statistics by World Health Organization Subtypes|url=https://pubmed.ncbi.nlm.nih.gov/27618563/|language=en|pmid=27618563}}</ref></blockquote> |
==Clinical Features== | ==Clinical Features== | ||
− | |||
− | |||
{| class="wikitable" | {| class="wikitable" | ||
|'''Signs and Symptoms''' | |'''Signs and Symptoms''' | ||
− | | | + | | |
− | + | *Asymptomatic (incidental finding on complete blood counts) | |
− | + | *B-symptoms (weight loss, fever, night sweats) | |
− | + | *Fatigue | |
− | + | *Splenic enlargement and discomfort | |
− | + | *Recurrent infections | |
− | + | *Lymphadenopathy (rare) | |
|- | |- | ||
|'''Laboratory Findings''' | |'''Laboratory Findings''' | ||
− | | | + | |Pancytopenia (monocytopenia is characteristic) |
− | + | Lymphocytosis (low level) | |
− | |||
|} | |} | ||
− | <blockquote class= | + | <blockquote class="blockedit">{{Box-round|title=v4:Clinical Features|The content below was from the old template. Please incorporate above.}} |
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*B-symptoms (weight loss, fever, night sweats) | *B-symptoms (weight loss, fever, night sweats) | ||
*Fatigue | *Fatigue | ||
− | * | + | *LUQ pain (splenomegaly) |
− | |||
*Lymphadenopathy (uncommon) | *Lymphadenopathy (uncommon) | ||
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*Monocytopenia | *Monocytopenia | ||
*Lymphocytosis (low level) | *Lymphocytosis (low level) | ||
− | + | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":1" /><ref name=":2">{{Cite journal|last=Grever|first=Michael R.|last2=Abdel-Wahab|first2=Omar|last3=Andritsos|first3=Leslie A.|last4=Banerji|first4=Versha|last5=Barrientos|first5=Jacqueline|last6=Blachly|first6=James S.|last7=Call|first7=Timothy G.|last8=Catovsky|first8=Daniel|last9=Dearden|first9=Claire|date=2017|title=Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia|url=https://ashpublications.org/blood/article/129/5/553/36153/Consensus-guidelines-for-the-diagnosis-and|journal=Blood|language=en|volume=129|issue=5|pages=553–560|doi=10.1182/blood-2016-01-689422|issn=0006-4971|pmc=PMC5290982|pmid=27903528}}</ref></blockquote> | |
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</blockquote> | </blockquote> | ||
==Sites of Involvement== | ==Sites of Involvement== | ||
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*Spleen (red pulp) | *Spleen (red pulp) | ||
*Bone marrow | *Bone marrow | ||
− | * | + | *Liver |
− | *Blood | + | *Blood (small number) |
− | + | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":1" /><ref name=":2" /></blockquote> | |
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− | <blockquote class= | ||
==Morphologic Features== | ==Morphologic Features== | ||
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− | <blockquote class= | + | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":1" /><ref name=":2" /></blockquote> |
==Immunophenotype== | ==Immunophenotype== | ||
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{| class="wikitable sortable" | {| class="wikitable sortable" | ||
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!Finding!!Marker | !Finding!!Marker | ||
|- | |- | ||
− | |Positive ( | + | |Positive (B-cell lineage markersl)||CD19, CD20 (bright), CD22, PAX5, FMC7, sIg (bright, monoclonal) |
|- | |- | ||
− | |Positive ( | + | |Positive||CD200 (bright), CD11c, CD103, CD123, CD25, CD72, annexin‐A1, BRAF V600E, phospho-ERK |
|- | |- | ||
− | |Negative | + | |Negative||CD5, CD10 (10-20% may be positive), CD23, CD27 |
− | |||
− | |||
|} | |} | ||
− | <blockquote class= | + | <blockquote class="blockedit">{{Box-round|title=v4:Immunophenotype|The content below was from the old template. Please incorporate above.}} |
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− | <blockquote class= | + | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}<ref name=":1" /><ref name=":2" /></blockquote> |
</blockquote> | </blockquote> | ||
==Chromosomal Rearrangements (Gene Fusions)== | ==Chromosomal Rearrangements (Gene Fusions)== | ||
− | + | *No consistent gene fusions | |
− | + | *Single case report of IGH-BRAF fusion positive, BRAF p.Val600Glu mutation negative HCL<ref name=":3" /> | |
− | + | *Single case report of IGH-CCND1 fusion positive, BRAF p.Val600Glu mutation positive HCL<ref name=":4" /> | |
− | + | <blockquote class="blockedit">{{Box-round|title=v4:Chromosomal Rearrangements (Gene Fusions)|The content below was from the old template. Please incorporate above.}} | |
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*No consistent gene fusions | *No consistent gene fusions | ||
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− | <blockquote class= | + | <blockquote class="blockedit">{{Box-round|title=v4:Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications).|Please incorporate this section into the relevant tables found in: |
* Chromosomal Rearrangements (Gene Fusions) | * Chromosomal Rearrangements (Gene Fusions) | ||
* Individual Region Genomic Gain/Loss/LOH | * Individual Region Genomic Gain/Loss/LOH | ||
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==Individual Region Genomic Gain / Loss / LOH== | ==Individual Region Genomic Gain / Loss / LOH== | ||
− | + | {| class="wikitable" | |
− | + | !chromosome<ref name=":5" /><ref name=":6" /> | |
− | + | !Alteration | |
+ | !Consequence | ||
+ | !Prevalence | ||
+ | |- | ||
+ | |14q22-32 | ||
+ | |Heterozygous deletion | ||
+ | |Uncertain | ||
+ | |33% | ||
|- | |- | ||
− | + | |7q | |
− | + | |Heterozygous deletion | |
− | + | |LOH of BRAF p.Val600Glu | |
− | + | |9-21% | |
− | |||
|- | |- | ||
− | | | + | |13q |
− | + | |Deletion | |
− | + | |Loss of RB1, miR-15a, and miR-16-1 | |
− | | | + | |6% |
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|- | |- | ||
− | | | + | |5 |
− | + | |Gain | |
− | + | |Uncertain | |
− | | | + | |9-15% |
− | | | + | |} |
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− | |||
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− | |||
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− | |||
− | |||
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− | |||
− | |} | ||
− | <blockquote class= | + | <blockquote class="blockedit">{{Box-round|title=v4:Genomic Gain/Loss/LOH|The content below was from the old template. Please incorporate above.}} |
*Recurrent gains and losses were found to be absent in HCLs from Chinese patients<ref>{{Cite journal|last=Zhang|first=Rui|last2=Wu|first2=Yongli|last3=Wang|first3=Xianfu|last4=Lu|first4=Xianglan|last5=Li|first5=Yan|last6=Li|first6=Shibo|last7=Yan|first7=Xiaojing|date=2020|title=Difference of genomic copy numbers alterations between hairy cell leukemia-variant and classical hairy cell leukemia: a pilot retrospective study in Chinese|url=https://www.ncbi.nlm.nih.gov/pubmed/32132867|journal=International Journal of Medical Sciences|volume=17|issue=3|pages=325–331|doi=10.7150/ijms.39307|issn=1449-1907|pmc=7053350|pmid=32132867}}</ref> | *Recurrent gains and losses were found to be absent in HCLs from Chinese patients<ref>{{Cite journal|last=Zhang|first=Rui|last2=Wu|first2=Yongli|last3=Wang|first3=Xianfu|last4=Lu|first4=Xianglan|last5=Li|first5=Yan|last6=Li|first6=Shibo|last7=Yan|first7=Xiaojing|date=2020|title=Difference of genomic copy numbers alterations between hairy cell leukemia-variant and classical hairy cell leukemia: a pilot retrospective study in Chinese|url=https://www.ncbi.nlm.nih.gov/pubmed/32132867|journal=International Journal of Medical Sciences|volume=17|issue=3|pages=325–331|doi=10.7150/ijms.39307|issn=1449-1907|pmc=7053350|pmid=32132867}}</ref> | ||
{| class="wikitable" | {| class="wikitable" | ||
− | !chromosome<ref>{{Cite journal|last=Durham|first=Benjamin H.|last2=Getta|first2=Bartlomiej|last3=Dietrich|first3=Sascha|last4=Taylor|first4=Justin|last5=Won|first5=Helen|last6=Bogenberger|first6=James M.|last7=Scott|first7=Sasinya|last8=Kim|first8=Eunhee|last9=Chung|first9=Young Rock|date=2017|title=Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations|url=https://www.ncbi.nlm.nih.gov/pubmed/28801450|journal=Blood|volume=130|issue=14|pages=1644–1648|doi=10.1182/blood-2017-01-765107|issn=1528-0020|pmc=5630011|pmid=28801450}}</ref><ref>{{Cite journal|last=A|first=Nordgren|last2=M|first2=Corcoran|last3=A|first3=Sääf|last4=A|first4=Bremer|last5=Hc|first5=Kluin-Nelemans|last6=J|first6=Schoumans|last7=D|first7=Grandér|date=2010|title=Characterisation of Hairy Cell Leukaemia by Tiling Resolution Array-Based Comparative Genome Hybridisation: A Series of 13 Cases and Review of the Literature|url=https://pubmed.ncbi.nlm.nih.gov/19682064/|language=en|pmid=19682064}}</ref> | + | !chromosome<ref name=":5">{{Cite journal|last=Durham|first=Benjamin H.|last2=Getta|first2=Bartlomiej|last3=Dietrich|first3=Sascha|last4=Taylor|first4=Justin|last5=Won|first5=Helen|last6=Bogenberger|first6=James M.|last7=Scott|first7=Sasinya|last8=Kim|first8=Eunhee|last9=Chung|first9=Young Rock|date=2017|title=Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations|url=https://www.ncbi.nlm.nih.gov/pubmed/28801450|journal=Blood|volume=130|issue=14|pages=1644–1648|doi=10.1182/blood-2017-01-765107|issn=1528-0020|pmc=5630011|pmid=28801450}}</ref><ref name=":6">{{Cite journal|last=A|first=Nordgren|last2=M|first2=Corcoran|last3=A|first3=Sääf|last4=A|first4=Bremer|last5=Hc|first5=Kluin-Nelemans|last6=J|first6=Schoumans|last7=D|first7=Grandér|date=2010|title=Characterisation of Hairy Cell Leukaemia by Tiling Resolution Array-Based Comparative Genome Hybridisation: A Series of 13 Cases and Review of the Literature|url=https://pubmed.ncbi.nlm.nih.gov/19682064/|language=en|pmid=19682064}}</ref> |
!Alteration | !Alteration | ||
!Consequence | !Consequence | ||
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==Characteristic Chromosomal Patterns== | ==Characteristic Chromosomal Patterns== | ||
− | + | IGHV4-34 (Immunoglobulin heavy chain variable segment) utilization is seen only in 10%<ref name=":0" /> of HCL but has predictive and prognostic implications<ref name=":7" />. | |
− | + | <blockquote class="blockedit">{{Box-round|title=v4:Characteristic Chromosomal Aberrations / Patterns|The content below was from the old template. Please incorporate above.}} | |
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− | + | *IGHV4-34 (Immunoglobulin heavy chain variable segment) utilization is seen only in 10%<ref name=":0" /> of HCL but has predictive and prognostic implications<ref name=":7">{{Cite journal|last=Arons|first=Evgeny|last2=Kreitman|first2=Robert J.|date=2011|title=Molecular variant of hairy cell leukemia with poor prognosis|url=https://www.ncbi.nlm.nih.gov/pubmed/21599610|journal=Leukemia & Lymphoma|volume=52 Suppl 2|pages=99–102|doi=10.3109/10428194.2011.565841|issn=1029-2403|pmid=21599610}}</ref>. | |
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− | *IGHV4-34 (Immunoglobulin heavy chain variable segment) utilization is seen only in 10%<ref name=":0" /> of HCL but has predictive and prognostic implications<ref>{{Cite journal|last=Arons|first=Evgeny|last2=Kreitman|first2=Robert J.|date=2011|title=Molecular variant of hairy cell leukemia with poor prognosis|url=https://www.ncbi.nlm.nih.gov/pubmed/21599610|journal=Leukemia & Lymphoma|volume=52 Suppl 2|pages=99–102|doi=10.3109/10428194.2011.565841|issn=1029-2403|pmid=21599610}}</ref>. | ||
</blockquote> | </blockquote> | ||
==Gene Mutations (SNV / INDEL)== | ==Gene Mutations (SNV / INDEL)== | ||
− | + | {| class="wikitable" | |
− | + | |- | |
− | + | !Gene<sup>‡</sup>!!Oncogene/Tumor Suppressor/Other!!Presumed Mechanism | |
− | + | (LOF/GOF/Other) | |
+ | !Prevalence<ref name=":1" /> | ||
+ | |- | ||
+ | |[[BRAF]]||Oncogene||GOF||70-100%* | ||
+ | |- | ||
+ | |[[MAP2K1]] | ||
+ | |Oncogene | ||
+ | |GOF | ||
+ | |0-22%* | ||
+ | |- | ||
+ | |[[TP53]] | ||
+ | |Tumor Suppressor | ||
+ | |LOF | ||
+ | |2-28% | ||
+ | |- | ||
+ | |KLF2 | ||
+ | |Oncogene/Tumor Suppressor | ||
+ | |context dependent<ref name=":8" /> | ||
+ | |13-16% | ||
+ | |- | ||
+ | |CDKN1B | ||
+ | |Tumor Suppressor | ||
+ | |LOF | ||
+ | |10-16% | ||
+ | |- | ||
+ | |ARID1A | ||
+ | |Tumor Suppressor | ||
+ | |LOF | ||
+ | |4-5% | ||
|- | |- | ||
− | + | |KMT2C | |
− | + | |Tumor Suppressor | |
− | + | |LOF | |
− | + | |15% | |
− | |||
|- | |- | ||
− | | | + | |CREBBP |
+ | |Tumor Suppressor | ||
+ | |LOF | ||
+ | |5-6% | ||
+ | |} | ||
− | |||
− | + | <sup>‡</sup>Specific mutations in these genes can be found in [https://www.cbioportal.org/ cBioPortal] and [https://cancer.sanger.ac.uk/cosmic COSMIC]. | |
− | + | '''*'''The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain. These seem to be more similar molecularly and clinically to [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|HCLv]]. | |
− | |||
− | | | ||
− | + | *BRAF and MAP2K1 activating mutations are mutually exclusive | |
− | + | *BRAF p.Val600Glu and MAP2K1 account for the primary oncogene drivers in the majority of HCL (~95%) | |
− | + | *BRAF p.Val600Glu (p.V600E) accounts for the majority of BRAF mutations, but other have been reported<ref name=":9" /> | |
− | + | *HCLs that utilize the IGVH4-34 segment lack BRAF p.Val600Glu mutations<ref name=":10" /> and instead harbor MAP2K1 mutations in most cases<ref name=":11" /> | |
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{| class="wikitable" | {| class="wikitable" | ||
|- | |- | ||
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|KLF2 | |KLF2 | ||
|Oncogene/Tumor Suppressor | |Oncogene/Tumor Suppressor | ||
− | |context dependent<ref>{{Cite journal|last=Wang|first=Chunmei|last2=Li|first2=Liang|last3=Duan|first3=Qiuhui|last4=Wang|first4=Qingqing|last5=Chen|first5=Jinlian|date=2017|title=Krüppel-like factor 2 suppresses human gastric tumorigenesis through inhibiting PTEN/AKT signaling|url=https://www.ncbi.nlm.nih.gov/pubmed/29245984|journal=Oncotarget|volume=8|issue=59|pages=100358–100370|doi=10.18632/oncotarget.22229|issn=1949-2553|pmc=5725026|pmid=29245984}}</ref> | + | |context dependent<ref name=":8">{{Cite journal|last=Wang|first=Chunmei|last2=Li|first2=Liang|last3=Duan|first3=Qiuhui|last4=Wang|first4=Qingqing|last5=Chen|first5=Jinlian|date=2017|title=Krüppel-like factor 2 suppresses human gastric tumorigenesis through inhibiting PTEN/AKT signaling|url=https://www.ncbi.nlm.nih.gov/pubmed/29245984|journal=Oncotarget|volume=8|issue=59|pages=100358–100370|doi=10.18632/oncotarget.22229|issn=1949-2553|pmc=5725026|pmid=29245984}}</ref> |
|13-16% | |13-16% | ||
|- | |- | ||
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*BRAF and MAP2K1 activating mutations are mutually exclusive | *BRAF and MAP2K1 activating mutations are mutually exclusive | ||
*BRAF p.Val600Glu and MAP2K1 account for the primary oncogene drivers in the majority of HCL (~95%) | *BRAF p.Val600Glu and MAP2K1 account for the primary oncogene drivers in the majority of HCL (~95%) | ||
− | *BRAF p.Val600Glu (p.V600E) accounts for the majority of BRAF mutations, but other have been reported<ref>{{Cite journal|last=Tschernitz|first=Sebastian|last2=Flossbach|first2=Lucia|last3=Bonengel|first3=Margrit|last4=Roth|first4=Sabine|last5=Rosenwald|first5=Andreas|last6=Geissinger|first6=Eva|date=2014|title=Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias|url=https://www.ncbi.nlm.nih.gov/pubmed/24433452|journal=British Journal of Haematology|volume=165|issue=4|pages=529–533|doi=10.1111/bjh.12735|issn=1365-2141|pmid=24433452}}</ref> | + | *BRAF p.Val600Glu (p.V600E) accounts for the majority of BRAF mutations, but other have been reported<ref name=":9">{{Cite journal|last=Tschernitz|first=Sebastian|last2=Flossbach|first2=Lucia|last3=Bonengel|first3=Margrit|last4=Roth|first4=Sabine|last5=Rosenwald|first5=Andreas|last6=Geissinger|first6=Eva|date=2014|title=Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias|url=https://www.ncbi.nlm.nih.gov/pubmed/24433452|journal=British Journal of Haematology|volume=165|issue=4|pages=529–533|doi=10.1111/bjh.12735|issn=1365-2141|pmid=24433452}}</ref> |
− | *HCLs that utilize the IGVH4-34 segment lack BRAF p.Val600Glu mutations<ref>{{Cite journal|last=Xi|first=Liqiang|last2=Arons|first2=Evgeny|last3=Navarro|first3=Winnifred|last4=Calvo|first4=Katherine R.|last5=Stetler-Stevenson|first5=Maryalice|last6=Raffeld|first6=Mark|last7=Kreitman|first7=Robert J.|date=2012|title=Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation|url=https://www.ncbi.nlm.nih.gov/pubmed/22210875|journal=Blood|volume=119|issue=14|pages=3330–3332|doi=10.1182/blood-2011-09-379339|issn=1528-0020|pmc=3321859|pmid=22210875}}</ref> and instead harbor MAP2K1 mutations in most cases<ref>{{Cite journal|last=Waterfall|first=Joshua J.|last2=Arons|first2=Evgeny|last3=Walker|first3=Robert L.|last4=Pineda|first4=Marbin|last5=Roth|first5=Laura|last6=Killian|first6=J. Keith|last7=Abaan|first7=Ogan D.|last8=Davis|first8=Sean R.|last9=Kreitman|first9=Robert J.|date=2014|title=High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias|url=https://www.ncbi.nlm.nih.gov/pubmed/24241536|journal=Nature Genetics|volume=46|issue=1|pages=8–10|doi=10.1038/ng.2828|issn=1546-1718|pmc=3905739|pmid=24241536}}</ref> | + | *HCLs that utilize the IGVH4-34 segment lack BRAF p.Val600Glu mutations<ref name=":10">{{Cite journal|last=Xi|first=Liqiang|last2=Arons|first2=Evgeny|last3=Navarro|first3=Winnifred|last4=Calvo|first4=Katherine R.|last5=Stetler-Stevenson|first5=Maryalice|last6=Raffeld|first6=Mark|last7=Kreitman|first7=Robert J.|date=2012|title=Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation|url=https://www.ncbi.nlm.nih.gov/pubmed/22210875|journal=Blood|volume=119|issue=14|pages=3330–3332|doi=10.1182/blood-2011-09-379339|issn=1528-0020|pmc=3321859|pmid=22210875}}</ref> and instead harbor MAP2K1 mutations in most cases<ref name=":11">{{Cite journal|last=Waterfall|first=Joshua J.|last2=Arons|first2=Evgeny|last3=Walker|first3=Robert L.|last4=Pineda|first4=Marbin|last5=Roth|first5=Laura|last6=Killian|first6=J. Keith|last7=Abaan|first7=Ogan D.|last8=Davis|first8=Sean R.|last9=Kreitman|first9=Robert J.|date=2014|title=High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias|url=https://www.ncbi.nlm.nih.gov/pubmed/24241536|journal=Nature Genetics|volume=46|issue=1|pages=8–10|doi=10.1038/ng.2828|issn=1546-1718|pmc=3905739|pmid=24241536}}</ref> |
</blockquote> | </blockquote> | ||
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==Genes and Main Pathways Involved== | ==Genes and Main Pathways Involved== | ||
− | |||
− | |||
{| class="wikitable sortable" | {| class="wikitable sortable" | ||
|- | |- | ||
− | ! | + | !Molecular feature!!Pathway!!Pathophysiologic outcome |
|- | |- | ||
− | | | + | |BRAF & MAP2K1 activating mutations |
− | | | + | (IGH-BRAF fusion, 1 report<ref name=":3" />) |
− | | | + | |MAPK signaling |
+ | |Increased cell growth and proliferation | ||
|- | |- | ||
− | | | + | |CDKN1B inactivating mutations |
− | | | + | (IGH-CCND1 fusion, 1 report<ref name=":4" />) |
− | | | + | |Cell cycle regulation |
+ | |Unregulated cell division | ||
|- | |- | ||
− | | | + | |KMT2C & ARID1A inactivating mutaitons |
− | | | + | |Histone modification, chromatin remodeling |
− | | | + | |Abnormal gene expression program |
|} | |} | ||
− | <blockquote class= | + | <blockquote class="blockedit">{{Box-round|title=v4:Genes and Main Pathways Involved|The content below was from the old template. Please incorporate above.}} |
{| class="wikitable" | {| class="wikitable" | ||
!Molecular feature | !Molecular feature | ||
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(use the "Cite" icon at the top of the page) <span style="color:#0070C0">(''Instructions: Add each reference into the text above by clicking on where you want to insert the reference, selecting the “Cite” icon at the top of the page, and using the “Automatic” tab option to search such as by PMID to select the reference to insert. The reference list in this section will be automatically generated and sorted.''</span> <span style="color:#0070C0">''If a PMID is not available, such as for a book, please use the “Cite” icon, select “Manual” and then “Basic Form”, and include the entire reference''</span><span style="color:#0070C0">''.''</span><span style="color:#0070C0">) </span> <references /> | (use the "Cite" icon at the top of the page) <span style="color:#0070C0">(''Instructions: Add each reference into the text above by clicking on where you want to insert the reference, selecting the “Cite” icon at the top of the page, and using the “Automatic” tab option to search such as by PMID to select the reference to insert. The reference list in this section will be automatically generated and sorted.''</span> <span style="color:#0070C0">''If a PMID is not available, such as for a book, please use the “Cite” icon, select “Manual” and then “Basic Form”, and include the entire reference''</span><span style="color:#0070C0">''.''</span><span style="color:#0070C0">) </span> <references /> | ||
− | + | <br /> | |
==Notes== | ==Notes== | ||
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome. | <nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome. | ||
<nowiki>*</nowiki>''Citation of this Page'': “Hairy cell leukaemia”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/HAEM5:Hairy_cell_leukaemia</nowiki>. | <nowiki>*</nowiki>''Citation of this Page'': “Hairy cell leukaemia”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated {{REVISIONMONTH}}/{{REVISIONDAY}}/{{REVISIONYEAR}}, <nowiki>https://ccga.io/index.php/HAEM5:Hairy_cell_leukaemia</nowiki>. | ||
− | [[Category:HAEM5]][[Category:DISEASE]][[Category:Diseases H]] | + | [[Category:HAEM5]] |
+ | [[Category:DISEASE]] | ||
+ | [[Category:Diseases H]] |
Latest revision as of 17:27, 6 September 2024
Haematolymphoid Tumours (WHO Classification, 5th ed.)
![]() | This page is under construction |
editContent Update To WHO 5th Edition Classification Is In Process; Content Below is Based on WHO 4th Edition ClassificationThis page was converted to the new template on 2023-12-07. The original page can be found at HAEM4:Hairy Cell Leukemia.
(General Instructions – The main focus of these pages is the clinically significant genetic alterations in each disease type. Use HUGO-approved gene names and symbols (italicized when appropriate), HGVS-based nomenclature for variants, as well as generic names of drugs and testing platforms or assays if applicable. Please complete tables whenever possible and do not delete them (add N/A if not applicable in the table and delete the examples); to add (or move) a row or column to a table, click within the table and select the > symbol that appears to be given options. Please do not delete or alter the section headings. The use of bullet points alongside short blocks of text rather than only large paragraphs is encouraged. Additional instructions below in italicized blue text should not be included in the final page content. Please also see Author_Instructions and FAQs as well as contact your Associate Editor or Technical Support)
Primary Author(s)*
- Michael Lack, DO, Shivani Golem, PhD FACMG
WHO Classification of Disease
Structure | Disease |
---|---|
Book | Haematolymphoid Tumours (5th ed.) |
Category | B-cell lymphoid proliferations and lymphomas |
Family | Mature B-cell neoplasms |
Type | Splenic B-cell lymphomas and leukaemias |
Subtype(s) | Hairy cell leukaemia |
Definition / Description of Disease
- Hairy cell leukemia (HCL) is a rare indolent neoplasm of B-cell origin seen mostly in adults
- Name derives from the the hair-like projections of the cytoplasm that surround the cells
- Hairy cells most closely resemble mature lymphoid cells
- Marked splenomegaly and marrow infiltration result in left flank discomfort, fatigue, and susceptibility to infections
- Most respond well to monotherapy with a purine analog or interferon alpha
Synonyms / Terminology
- Leukemic reticuloendotheliosis
Epidemiology / Prevalence
- Incidence (age adjusted) ~ 0.3/100,000
- 2% of lymphoid leukemias
- Median age: 58 years, rarely in patients in their 20s
- Males:Females: 4:1
- Whites >> Blacks
- 78% to 92% 5yr survival
editUnassigned ReferencesThe following referenees were placed in the header. Please place them into the appropriate locations in the text.
Clinical Features
Signs and Symptoms |
|
Laboratory Findings | Pancytopenia (monocytopenia is characteristic)
Lymphocytosis (low level) |
editv4:Clinical FeaturesThe content below was from the old template. Please incorporate above.
Signs & Symptoms
- Asymptomatic (incidental finding on complete blood counts)
- B-symptoms (weight loss, fever, night sweats)
- Fatigue
- LUQ pain (splenomegaly)
- Lymphadenopathy (uncommon)
Laboratory findings
- Cytopenias
- Monocytopenia
- Lymphocytosis (low level)
editUnassigned ReferencesThe following referenees were placed in the header. Please place them into the appropriate locations in the text.
Sites of Involvement
- Spleen (red pulp)
- Bone marrow
- Liver
- Blood (small number)
editUnassigned ReferencesThe following referenees were placed in the header. Please place them into the appropriate locations in the text.
Morphologic Features
- Small lymphoid cells
- Abundant pale blue-grey lacey cytoplasm
- Ovoid nuclei ± indentation or folding
- Inconspicuous nucleoli
- Circumferential hairy projections (smear preparations)
- "Fried egg" appearance of cells (tissue sections)
- Marrow (reticulin) fibrosis
editUnassigned ReferencesThe following referenees were placed in the header. Please place them into the appropriate locations in the text.
Immunophenotype
Finding | Marker |
---|---|
Positive (B-cell lineage markersl) | CD19, CD20 (bright), CD22, PAX5, FMC7, sIg (bright, monoclonal) |
Positive | CD200 (bright), CD11c, CD103, CD123, CD25, CD72, annexin‐A1, BRAF V600E, phospho-ERK |
Negative | CD5, CD10 (10-20% may be positive), CD23, CD27 |
editv4:ImmunophenotypeThe content below was from the old template. Please incorporate above.
Finding Marker Positive (B-cell lineage markers) CD19, CD20 (bright), CD22, PAX5, FMC7, sIg (bright, monoclonal) Positive CD200 (bright), CD11c, CD103, CD123, CD25, CD72, annexin‐A1, BRAF V600E, phospho-ERK Negative CD5, CD10 (10-20% may be positive), CD23, CD27
editUnassigned ReferencesThe following referenees were placed in the header. Please place them into the appropriate locations in the text.
Chromosomal Rearrangements (Gene Fusions)
- No consistent gene fusions
- Single case report of IGH-BRAF fusion positive, BRAF p.Val600Glu mutation negative HCL[4]
- Single case report of IGH-CCND1 fusion positive, BRAF p.Val600Glu mutation positive HCL[5]
editv4:Chromosomal Rearrangements (Gene Fusions)The content below was from the old template. Please incorporate above.
editv4:Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications).Please incorporate this section into the relevant tables found in:
- Chromosomal Rearrangements (Gene Fusions)
- Individual Region Genomic Gain/Loss/LOH
- Characteristic Chromosomal Patterns
- Gene Mutations (SNV/INDEL)
Alteration Clinical Significance Note BRAF p.Val600Glu Predictive* vemurafenib for 2nd line; vemurafenib ± rituximab for 3rd line (NCCN, v 1.2020, pg. HCL-A)[6] BRAF p.Val600Glu Diagnostic May be useful when immunophenotype is equivocal; Excludes HCLv MAP2K1 Predictive Certain mutations may confer sensitivity to ERK inhibitors IGHV4-34 utilization Predictive Reduced response to purine analogs[7] IGHV4-34 utilization Prognostic Less favorable prognosis[7] *Not all BRAF mutations confer sensitivity to BRAF inhibitors, even if they are activating mutations[8].
Individual Region Genomic Gain / Loss / LOH
chromosome[9][10] | Alteration | Consequence | Prevalence |
---|---|---|---|
14q22-32 | Heterozygous deletion | Uncertain | 33% |
7q | Heterozygous deletion | LOH of BRAF p.Val600Glu | 9-21% |
13q | Deletion | Loss of RB1, miR-15a, and miR-16-1 | 6% |
5 | Gain | Uncertain | 9-15% |
editv4:Genomic Gain/Loss/LOHThe content below was from the old template. Please incorporate above.
- Recurrent gains and losses were found to be absent in HCLs from Chinese patients[11]
chromosome[9][10] Alteration Consequence Prevalence 14q22-32 Heterozygous deletion Uncertain 33% 7q Heterozygous deletion LOH of BRAF p.Val600Glu 9-21% 13q Deletion Loss of RB1, miR-15a, and miR-16-1 6% 5 Gain Uncertain 9-15%
Characteristic Chromosomal Patterns
IGHV4-34 (Immunoglobulin heavy chain variable segment) utilization is seen only in 10%[7] of HCL but has predictive and prognostic implications[12].
editv4:Characteristic Chromosomal Aberrations / PatternsThe content below was from the old template. Please incorporate above.
Gene Mutations (SNV / INDEL)
Gene‡ | Oncogene/Tumor Suppressor/Other | Presumed Mechanism
(LOF/GOF/Other) |
Prevalence[1] |
---|---|---|---|
BRAF | Oncogene | GOF | 70-100%* |
MAP2K1 | Oncogene | GOF | 0-22%* |
TP53 | Tumor Suppressor | LOF | 2-28% |
KLF2 | Oncogene/Tumor Suppressor | context dependent[13] | 13-16% |
CDKN1B | Tumor Suppressor | LOF | 10-16% |
ARID1A | Tumor Suppressor | LOF | 4-5% |
KMT2C | Tumor Suppressor | LOF | 15% |
CREBBP | Tumor Suppressor | LOF | 5-6% |
‡Specific mutations in these genes can be found in cBioPortal and COSMIC.
*The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain. These seem to be more similar molecularly and clinically to HCLv.
- BRAF and MAP2K1 activating mutations are mutually exclusive
- BRAF p.Val600Glu and MAP2K1 account for the primary oncogene drivers in the majority of HCL (~95%)
- BRAF p.Val600Glu (p.V600E) accounts for the majority of BRAF mutations, but other have been reported[14]
- HCLs that utilize the IGVH4-34 segment lack BRAF p.Val600Glu mutations[15] and instead harbor MAP2K1 mutations in most cases[16]
editv4:Gene Mutations (SNV/INDEL)The content below was from the old template. Please incorporate above.
Gene‡ Oncogene/Tumor Suppressor/Other Presumed Mechanism (LOF/GOF/Other)
Prevalence[1] BRAF Oncogene GOF 70-100%* MAP2K1 Oncogene GOF 0-22%* TP53 Tumor Suppressor LOF 2-28% KLF2 Oncogene/Tumor Suppressor context dependent[13] 13-16% CDKN1B Tumor Suppressor LOF 10-16% ARID1A Tumor Suppressor LOF 4-5% KMT2C Tumor Suppressor LOF 15% CREBBP Tumor Suppressor LOF 5-6% ‡Specific mutations in these genes can be found in cBioPortal and COSMIC.
*The WHO states that BRAF p.Val600Glu is detected in virtually all cases and notes that the classification of B-cell leukemias that are immunophenotypically and morphologically classified as HCL but lack BRAF activating mutations (but instead have MAP2K1 activating mutations and use the IGHV4-34 gene segment) is uncertain. These seem to be more similar molecularly and clinically to HCLv.
- BRAF and MAP2K1 activating mutations are mutually exclusive
- BRAF p.Val600Glu and MAP2K1 account for the primary oncogene drivers in the majority of HCL (~95%)
- BRAF p.Val600Glu (p.V600E) accounts for the majority of BRAF mutations, but other have been reported[14]
- HCLs that utilize the IGVH4-34 segment lack BRAF p.Val600Glu mutations[15] and instead harbor MAP2K1 mutations in most cases[16]
Epigenomic Alterations
- Altered epigenetic regulation is expected due to alterations in KMT2C and ARID1A in a subset of HCLs
- KMT2C is a histone methyltransferase
- ARID1A is a SWI/SNF family member
Genes and Main Pathways Involved
Molecular feature | Pathway | Pathophysiologic outcome |
---|---|---|
BRAF & MAP2K1 activating mutations
(IGH-BRAF fusion, 1 report[4]) |
MAPK signaling | Increased cell growth and proliferation |
CDKN1B inactivating mutations
(IGH-CCND1 fusion, 1 report[5]) |
Cell cycle regulation | Unregulated cell division |
KMT2C & ARID1A inactivating mutaitons | Histone modification, chromatin remodeling | Abnormal gene expression program |
editv4:Genes and Main Pathways InvolvedThe content below was from the old template. Please incorporate above.
Molecular feature Pathway Pathophysiologic outcome BRAF & MAP2K1 activating mutations (IGH-BRAF fusion, 1 report[4])
MAPK signaling Increased cell growth and proliferation CDKN1B inactivating mutations (IGH-CCND1 fusion, 1 report[5])
Cell cycle regulation Unregulated cell division KMT2C & ARID1A inactivating mutaitons Histone modification, chromatin remodeling Abnormal gene expression program
Genetic Diagnostic Testing Methods
- Morphology and immunophenotyping (IHC or flow cytometry) are adequate for diagnosis in nearly all cases
- BRAF p.Val600Glu testing may be useful diagnostically in rare situations where clinicopathologic findings are equivocal
- BRAF p.Val600Glu may be detected by IHC using a mutant-specific antibody[17][18] or various molecular methods (NGS, real-time PCR, massARRAY, etc.)
- The mutant-specific antibody does not detect other BRAF mutations
- BRAF p.Val600Glu and Non-p.Val600Glu mutations and MAP2K1 mutations can be interrogated with NGS in a single assay[1]
- IGHV4-34 utilization can be detected by NGS
Familial Forms
- Familial association has been reported in several case reports
- Some linked to various HLA type[19]
- Others to familial occupation[20]
Additional Information
- N/A
Links
- HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli
- HAEM5:Splenic diffuse red pulp small B-cell lymphoma
References
(use the "Cite" icon at the top of the page) (Instructions: Add each reference into the text above by clicking on where you want to insert the reference, selecting the “Cite” icon at the top of the page, and using the “Automatic” tab option to search such as by PMID to select the reference to insert. The reference list in this section will be automatically generated and sorted. If a PMID is not available, such as for a book, please use the “Cite” icon, select “Manual” and then “Basic Form”, and include the entire reference.)
- ↑ 1.0 1.1 1.2 1.3 1.4 1.5 1.6 1.7 Maitre, Elsa; et al. (2019). "Hairy cell leukemia: 2020 update on diagnosis, risk stratification, and treatment". American Journal of Hematology. 94 (12): 1413–1422. doi:10.1002/ajh.25653. ISSN 1096-8652. PMID 31591741.
- ↑ Lr, Teras; et al. (2016). "2016 US Lymphoid Malignancy Statistics by World Health Organization Subtypes". PMID 27618563.
- ↑ 3.0 3.1 3.2 3.3 Grever, Michael R.; et al. (2017). "Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia". Blood. 129 (5): 553–560. doi:10.1182/blood-2016-01-689422. ISSN 0006-4971. PMC 5290982. PMID 27903528.CS1 maint: PMC format (link)
- ↑ 4.0 4.1 4.2 4.3 Thompson, Ella R.; et al. (2020). "Detection of an IGH-BRAF fusion in a patient with BRAF Val600Glu negative hairy cell leukemia". Leukemia & Lymphoma: 1–3. doi:10.1080/10428194.2020.1753045. ISSN 1029-2403. PMID 32319330 Check
|pmid=
value (help). - ↑ 5.0 5.1 5.2 5.3 Rahman, Zaid Abdel; et al. (2020). "Hairy cell leukemia with CCND1/IGH fusion gene and BRAF V600E mutation". Leukemia Research Reports. 13: 100197. doi:10.1016/j.lrr.2020.100197. ISSN 2213-0489. PMC 7096740 Check
|pmc=
value (help). PMID 32257795 Check|pmid=
value (help). - ↑ National Comprehensive Cancer Network (January 2020). "NCCN Clinical Practice Guidelines in Oncology: Hairy Cell Leukemia" (PDF).CS1 maint: display-authors (link)
- ↑ 7.0 7.1 7.2 7.3 Arons, Evgeny; et al. (2009). "VH4-34+ hairy cell leukemia, a new variant with poor prognosis despite standard therapy". Blood. 114 (21): 4687–4695. doi:10.1182/blood-2009-01-201731. ISSN 1528-0020. PMC 2780305. PMID 19745070.
- ↑ Bracht, Jillian Wilhelmina Paulina; et al. (2019). "BRAF Mutations Classes I, II, and III in NSCLC Patients Included in the SLLIP Trial: The Need for a New Pre-Clinical Treatment Rationale". Cancers. 11 (9). doi:10.3390/cancers11091381. ISSN 2072-6694. PMC 6770188. PMID 31533235.
- ↑ 9.0 9.1 Durham, Benjamin H.; et al. (2017). "Genomic analysis of hairy cell leukemia identifies novel recurrent genetic alterations". Blood. 130 (14): 1644–1648. doi:10.1182/blood-2017-01-765107. ISSN 1528-0020. PMC 5630011. PMID 28801450.
- ↑ 10.0 10.1 A, Nordgren; et al. (2010). "Characterisation of Hairy Cell Leukaemia by Tiling Resolution Array-Based Comparative Genome Hybridisation: A Series of 13 Cases and Review of the Literature". PMID 19682064.
- ↑ Zhang, Rui; et al. (2020). "Difference of genomic copy numbers alterations between hairy cell leukemia-variant and classical hairy cell leukemia: a pilot retrospective study in Chinese". International Journal of Medical Sciences. 17 (3): 325–331. doi:10.7150/ijms.39307. ISSN 1449-1907. PMC 7053350 Check
|pmc=
value (help). PMID 32132867 Check|pmid=
value (help). - ↑ 12.0 12.1 Arons, Evgeny; et al. (2011). "Molecular variant of hairy cell leukemia with poor prognosis". Leukemia & Lymphoma. 52 Suppl 2: 99–102. doi:10.3109/10428194.2011.565841. ISSN 1029-2403. PMID 21599610.
- ↑ 13.0 13.1 Wang, Chunmei; et al. (2017). "Krüppel-like factor 2 suppresses human gastric tumorigenesis through inhibiting PTEN/AKT signaling". Oncotarget. 8 (59): 100358–100370. doi:10.18632/oncotarget.22229. ISSN 1949-2553. PMC 5725026. PMID 29245984.
- ↑ 14.0 14.1 Tschernitz, Sebastian; et al. (2014). "Alternative BRAF mutations in BRAF V600E-negative hairy cell leukaemias". British Journal of Haematology. 165 (4): 529–533. doi:10.1111/bjh.12735. ISSN 1365-2141. PMID 24433452.
- ↑ 15.0 15.1 Xi, Liqiang; et al. (2012). "Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation". Blood. 119 (14): 3330–3332. doi:10.1182/blood-2011-09-379339. ISSN 1528-0020. PMC 3321859. PMID 22210875.
- ↑ 16.0 16.1 Waterfall, Joshua J.; et al. (2014). "High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias". Nature Genetics. 46 (1): 8–10. doi:10.1038/ng.2828. ISSN 1546-1718. PMC 3905739. PMID 24241536.
- ↑ Ritterhouse, Lauren L.; et al. (2015). "BRAF V600E mutation-specific antibody: A review". Seminars in Diagnostic Pathology. 32 (5): 400–408. doi:10.1053/j.semdp.2015.02.010. ISSN 0740-2570. PMID 25744437.
- ↑ Loo, Eric; et al. (2018). "BRAF V600E Mutation Across Multiple Tumor Types: Correlation Between DNA-based Sequencing and Mutation-specific Immunohistochemistry". Applied immunohistochemistry & molecular morphology: AIMM. 26 (10): 709–713. doi:10.1097/PAI.0000000000000516. ISSN 1533-4058. PMID 29271794.
- ↑ Villemagne, Bruno; et al. (2005). "Two new cases of familial hairy cell leukemia associated with HLA haplotypes A2, B7, Bw4, Bw6". Leukemia & Lymphoma. 46 (2): 243–245. doi:10.1080/10428190400013589. ISSN 1042-8194. PMID 15621808.
- ↑ Casado, L. F.; et al. (1998). "Familial hairy cell leukemia: a HLA-linked disease or farmers-linked disease?". Haematologica. 83 (8): 751–752. ISSN 0390-6078. PMID 9793263.
Notes
*Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome. *Citation of this Page: “Hairy cell leukaemia”. Compendium of Cancer Genome Aberrations (CCGA), Cancer Genomics Consortium (CGC), updated 09/6/2024, https://ccga.io/index.php/HAEM5:Hairy_cell_leukaemia.