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**''TET2'' (50-80%)

**''DNMT3A'' (20-30%)

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~~==Genes and Main Pathways Involved==~~

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~~{| class="wikitable"~~

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~~!Molecular Features~~

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~~!Pathway~~

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~~!Pathophysiologic Outcome~~

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~~|''FYN'', ''PLCG1'', and ''CD28'' mutations~~

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~~|T-cell receptor signaling pathway<ref name=":4" /><ref name=":6" /><ref name=":3" /><ref name=":13" />~~

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~~|Increased proliferation and survival~~

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~~|''IDH2'', ''TET2'', and ''DNMT3A'' mutations~~

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~~|Histone modification and chromatin remodeling<ref name=":4" /><ref name=":5" /><ref name=":11" /><ref name=":12" />~~

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~~|Abnormal gene expression program~~

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|}

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==Diagnostic Testing Methods==

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