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Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray (view source)
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==Recurrent Genomic Alterations in Pediatric and Adult CNS Detected by Chromosomal Microarray (Literature Review)==
+==Recurrent Genomic Alterations in Pediatric and Adult CNS Detected by Chromosomal Microarray
−Table 1 - Pediatric Central Nervous System Tumors. Table derived from Ligon et al., 2018 [ ] with permission from Cancer Genetics.
+Table 1 - Pediatric Central Nervous System Tumors. Table derived from CGC CNS Workgroup 2018.
{| class="wikitable"
{| class="wikitable"
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| Generally indolent tumors for which surgical resection can be curative
| Generally indolent tumors for which surgical resection can be curative
| PMID:25461780; PMID:23583981; PMID:11996800 PMID:23609006; PMID:29880043
| PMID:25461780; PMID:23583981; PMID:11996800 PMID:23609006; PMID:29880043
+|-
+|Low grade glioma, WHO grade II
+|Diffuse astrocytoma
+|No diagnostic aberrations
+| '''Rearrangement:''' MYBL1 truncating rearrangements and tandem duplication, FGFR1 rearrangements; '''Mutation:''' FGFR1
+| Anaplastic features associated with decreased progression free survival
+| PMID:25664944; PMID:23633565; PMID:26061751 PMID:26824661; PMID:26004297; PMID:25461780 PMID:23583981
|-
|-
|
|
+| Pleomorphic xanthoastrocytoma (PXA)
+| Polysomy 3, polysomy 7 observed; '''Loss:''' monosomy 9 / 9p deletion
+| '''Mutations:''' BRAF V600E in ~60%; TP53 (5%); '''Loss:''' CDKN2A/CDKN2B
+|
+| PMID:25461780; PMID:23583981; PMID:16909113; PMID:12484572
+|-