Changes

'''[[Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms]]'''

'''[[Acute Myeloid Leukemia (AML) and Related Precursor Neoplasms]]'''

Mutations in ''SRSF2'', mostly affecting proline 95 (NM_003016.4), are found in ~7% of acute myeloid leukemia (AML) with myelodysplasia-related changes but rarely (<1%) in patients with de novo AML (Yoshida et al., 2011). One study found that ''SRSF2'' variants correlated with older age but no other prognostic markers in AML; however, AML sub-types were not separated (Yang et al., 2016).

Mutations in ''SRSF2'', mostly affecting proline 95 (NM_003016.4), are found in ~7% of acute myeloid leukemia (AML) with myelodysplasia-related changes but rarely (<1%) in patients with de novo AML (Yoshida et al., 2011). One study found that ''SRSF2'' variants correlated with older age but no other prognostic markers in AML; however, AML sub-types were not separated (Yang et al., 2016). Another study reported decreased survival in patients with ''SRSF2''-mutated AML, and concurrent ''SRSF2'' and ''ASXL1'' variants resulted in poorer probability of survival than either variant alone (Papaemmanuil et al., 2016).

==Gene Overview==

==Gene Overview==