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WT1 (view source)

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→‎Common Alteration Types

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==Common Alteration Types==

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The most common WT1 alterations are missense mutations in and around residue Arg394 (NM_024426.2) or nonsense mutations which truncate some or all of the C-terminal zinc finger DNA-binding domains, but a spectrum of genetic aberrations can be observed (source: COSMIC, https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=WT1, retrieved 2018-08-13).

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Paul.Defazio

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