BCR

Primary Author(s)*

Brian Davis, PhD

Synonyms

BCR, RhoGEF and GTPase activating protein; Breakpoint Cluster Region; BCR1; ALL; CML; PHL; D22S11; D22S662

Genomic Location

Cytoband: 22q11.23

Genomic Coordinates:

GRCh38.p12 23180365..23318037

Cancer Category/Type

Chronic Myeloid Leukemia (Chronic Myelogenous Leukemia)

Acute Lymphoid Leukemia

Gene Overview

The function of the normal BCR gene product is as a GTPase-activating protein for RAC1 and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. The protein has serine/threonine kinase activity. (1)

Mention that is haas coiled coil domain and prob. aggregates as Fusion BRC-ABL1.

Common Alteration Types

Put your text here and/or fill in the table with an X where applicable

Copy Number Loss	Copy Number Gain	LOH	Loss-of-Function Mutation	Gain-of-Function Mutation	Translocation/Fusion
EXAMPLE: X	EXAMPLE: X	EXAMPLE: X	EXAMPLE: X	EXAMPLE: X	EXAMPLE: X

Internal Pages

Put your text here

EXAMPLE Germline Cancer Predisposition Genes

External Links

Put your text here - Include as applicable links to: 1) Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2) COSMIC, 3) CIViC, 4) St. Jude ProteinPaint, 5) Precision Medicine Knnowledgebase (Weill Cornell), 6) Cancer Index, 7) OncoKB, 8) My Cancer Genome, 9) UniProt, 10) Pfam, 11) GeneCards, 12) GeneReviews, and 13) Any gene-specific databases.

EXAMPLES

BCR by Atlas of Genetics and Cytogenetics in Oncology and Haematology - detailed gene information

BCR by COSMIC - sequence information, expression, catalogue of mutations

BCR-ABL1 by CIViC - general knowledge and evidence-based variant specific information

BCR by St. Jude ProteinPaint mutational landscape and matched expression data.

BCR by Precision Medicine Knowledgebase (Weill Cornell) - manually vetted interpretations of variants and CNVs

BCR by Cancer Index - gene, pathway, publication information matched to cancer type

BCR-ABL1 by OncoKB - mutational landscape, mutation effect, variant classification

BCR by My Cancer Genome - brief gene overview

BCR by UniProt - protein and molecular structure and function

BCR by Pfam - gene and protein structure and function information

BCR by GeneCards - general gene information and summaries

BCR by OMIM - compendium of human genes and genetic phenotypes

References

1. Diekmann D. et al. (1991). Bcr encodes a GTPase-activating protein for p21rac. Nature 35: 400-2. PMID 1903516 DOI: 10.1038/351400a0

Notes

*Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.