ABL1

Primary Author(s)*

Brian Davis, PhD

Synonyms

ABL proto-oncogene 1 non-receptor tyrosine kinase, Abelson tyrosine-protein kinase 1, ABL, JTK7, p150, c-ABL, v-abl, CHDSKM, c-ABL1; bcr/abl

Genomic Location

Cytoband: 9q34.12

Genomic Coordinates:

chr9:130,713,881-130,887,675(GRCh38/hg38)

chr9:133,589,268-133,763,062(GRCh37/hg19)

Cancer Category/Type

Acute Lymphoid Leukemia

Chronic Myelogenous Leukemia

Gene Overview

Put your text here.

Common Alteration Types

Put your text here and/or fill in the table with an X where applicable

Copy Number Loss	Copy Number Gain	LOH	Loss-of-Function Mutation	Gain-of-Function Mutation	Translocation/Fusion
EXAMPLE: X	EXAMPLE: X	EXAMPLE: X	EXAMPLE: X	EXAMPLE: X	EXAMPLE: X

Internal Pages

Put your text here

EXAMPLE Germline Cancer Predisposition Genes

External Links

Put your text here - Include as applicable links to: 1) Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2) COSMIC, 3) CIViC, 4) St. Jude ProteinPaint, 5) Precision Medicine Knnowledgebase (Weill Cornell), 6) Cancer Index, 7) OncoKB, 8) My Cancer Genome, 9) UniProt, 10) Pfam, 11) GeneCards, 12) GeneReviews, and 13) Any gene-specific databases.

EXAMPLES

ABL1 by Atlas of Genetics and Cytogenetics in Oncology and Haematology - detailed gene information

ABL1 by COSMIC - sequence information, expression, catalogue of mutations

ABL1 by CIViC - general knowledge and evidence-based variant specific information

ABL1 by St. Jude ProteinPaint mutational landscape and matched expression data.

ABL1 by Precision Medicine Knowledgebase (Weill Cornell) - manually vetted interpretations of variants and CNVs

ABL1 by Cancer Index - gene, pathway, publication information matched to cancer type

ABL1 by OncoKB - mutational landscape, mutation effect, variant classification

ABL1 by My Cancer Genome - brief gene overview

ABL1 by UniProt - protein and molecular structure and function

ABL1 by Pfam - gene and protein structure and function information

ABL1 by GeneCards - general gene information and summaries

GeneReviews - information on Li Fraumeni Syndrome

References

EXAMPLE Book

1. Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.

EXAMPLE Journal Article

1. Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.

Notes

*Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome.