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Diffuse midline glioma, H3 K27M–mutant (view source)

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==Cancer Sub-Classification / Subtype==

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H3 K27M-mutant glioma

==Definition / Description of Disease==

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An infiltrative midline high-grade glioma with predominantly astrocytic differentiation and a K27M mutation in either H3F3A or HIST1H3B/C 1.

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H3 K27M-mutant diffuse midline glioma predominates in children, but can be seen in adults. It is a grade IV tumor even when mitotic figures, microvascular proliferation and necrosis are absent.

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In adults, this is a distinct subgroup of IDH wild-type gliomas characterized by a constant midline location, low rate of MGMT promoter methylation, and poor prognosis2.

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==Synonyms / Terminology==

Lindacooley

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