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| == Description == | | == Description == |
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− | NUP214-SET gene fusion | + | NUP214-SET is a fusion of the genes ''NUP214'' (Nucleoporin 214kDa) and ''SET'' (SET Nuclear Proto-Oncogene), located at 9q34.13 and 9q34.11, respectively. The fusion has been described as resulting from a recurrent cryptic deletion, del(9)(q34.11q34.13) and a chromosomal translocation, t(9;9)(q34;q34) [5,6]. In [[T-ALL| T-cell acute lymphoblastic leukemia]], the fusion has been shown to mediate elevated expression of [[HOXA| ''HOXA'']] cluster genes [7]. |
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| == Tumor Types == | | == Tumor Types == |
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− | [T-cell Acute Lymphoblastic Leukemia | + | [[T-ALL|T-cell Acute Lymphoblastic Leukemia/Lymphoma]] |
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− | <ref> Reference: Ann Clin Lab Sci. 2011 Summer;41(3):267-72.
| + | [[AML| Acute Myeloid Leukemia]] (single case report) |
− | T-cell acute lymphoblastic leukemia associated with complex karyotype and SET-NUP214 rearrangement: a case study and review of the literature.
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− | Lee SG1, Park TS, Cho SY, Lim G, Park GJ, Oh SH, Cho EH, Chong SY, Huh JY. PMID: 22075511 http://www.ncbi.nlm.nih.gov/pubmed/22075511</ref>
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− | <ref>Ann Hematol. 2012 Feb;91(2):193-201. doi: 10.1007/s00277-011-1289-x. Epub 2011 Jul 1.</ref>
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− | <ref>
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− | Phenotypic and genetic characterization of adult T-cell acute lymphoblastic leukemia with del(9)(q34);SET-NUP214 rearrangement.
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− | Chae H1, Lim J, Kim M, Park J, Kim Y, Han K, Lee S, Min WS. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21720744 Oncol Lett. 2014 Sep; 8(3): 959–962.
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− | Published online 2014 Jun 18. doi: 10.3892/ol.2014.2263 PMCID: PMC4114590</ref>
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− | <ref>
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− | NUP214 fusion genes in acute leukemia (Review)
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− | MIN-HANG ZHOU and QING-MING YANG PMID: http://www.ncbi.nlm.nih.gov/pubmed/25120641
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− | </ref>
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− | Rare: <ref>B-cell Lymphoid Leukemia Test Reference: Oncol Lett. 2016 Apr;11(4):2644-2650. Epub 2016 Feb 23.
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− | B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature.
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− | Zhu HH1, Zhao XS1, Qin YZ1, Lai YY1, Jiang H1 PMID:[http://www.ncbi.nlm.nih.gov/pubmed/ 27073532] </ref>
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| == Prevalence == | | == Prevalence == |
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| ==References== | | ==References== |
| + | <ref> Reference: Ann Clin Lab Sci. 2011 Summer;41(3):267-72. |
| + | T-cell acute lymphoblastic leukemia associated with complex karyotype and SET-NUP214 rearrangement: a case study and review of the literature. |
| + | Lee SG1, Park TS, Cho SY, Lim G, Park GJ, Oh SH, Cho EH, Chong SY, Huh JY. PMID: 22075511 http://www.ncbi.nlm.nih.gov/pubmed/22075511</ref> |
| + | |
| + | <ref>Ann Hematol. 2012 Feb;91(2):193-201. doi: 10.1007/s00277-011-1289-x. Epub 2011 Jul 1.</ref> |
| + | |
| + | <ref> |
| + | Phenotypic and genetic characterization of adult T-cell acute lymphoblastic leukemia with del(9)(q34);SET-NUP214 rearrangement. |
| + | Chae H1, Lim J, Kim M, Park J, Kim Y, Han K, Lee S, Min WS. PMID: http://www.ncbi.nlm.nih.gov/pubmed/21720744 Oncol Lett. 2014 Sep; 8(3): 959–962. |
| + | Published online 2014 Jun 18. doi: 10.3892/ol.2014.2263 PMCID: PMC4114590</ref> |
| + | |
| + | <ref> |
| + | NUP214 fusion genes in acute leukemia (Review) |
| + | MIN-HANG ZHOU and QING-MING YANG PMID: http://www.ncbi.nlm.nih.gov/pubmed/25120641 |
| + | </ref> |
| + | |
| + | <ref> SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines. Quentmeier H, Schneider B, Röhrs S, et al. J Hematol Oncol. 2009;2:3. PMID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636835/#B1 </ref> |
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| + | <ref> Characterization of the translocation breakpoint sequences of two DEK-CAN fusion genes present in t(6;9) acute myeloid leukemia and a SET-CAN fusion gene found in a case of acute undifferentiated leukemia. Genes Chromosomes Cancer. Von Lindern M, Breems D, van Baal S, Adriaansen H, Grosveld G. Genes Chromosomes Cancer. 1992;5:227–234. doi: 10.1002/gcc.2870050309. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1384675</ref> |
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| + | <ref> The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia. Van Vlierberghe, van Grotel M, Tchinda J, Lee C, Beverloo HB, van der Spek PJ, Stubbs A, Cools J, Nagata K, Fornerod M, Buijs-Gladdines J, Horstmann M, van Wering ER, Soulier J, Pieters R, Meijerink JP. Blood. 2008 May 1;111(9):4668-80. doi: 10.1182/blood-2007-09-111872. Epub 2008 Feb 25. PMID: http://www.ncbi.nlm.nih.gov/pubmed/18299449 </ref> |
| + | |
| + | Rare: <ref>B-cell Lymphoid Leukemia Test Reference: Oncol Lett. 2016 Apr;11(4):2644-2650. Epub 2016 Feb 23. |
| + | B-cell acute lymphoblastic leukemia associated with SET-NUP214 rearrangement: A case report and review of the literature. |
| + | Zhu HH1, Zhao XS1, Qin YZ1, Lai YY1, Jiang H1 PMID:[http://www.ncbi.nlm.nih.gov/pubmed/ 27073532] </ref> |