Compendium of Cancer Genome Aberrations

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Translocations et al. in Hematological Cancers (view source)

Revision as of 11:45, 26 August 2016

57 bytes removed ,  11:45, 26 August 2016
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__TOC__
 
__TOC__
   −
==Translocations Long List==
+
==Translocations==
    
{| class="wikitable"
 
{| class="wikitable"
Line 30: Line 30:  
|-
 
|-
 
|[[t(1;5)(q22;q33)]]
 
|[[t(1;5)(q22;q33)]]
−
|[[MPD with eosinophilia]],[[ CEL]],[[ B-ALL]]
+
|[[MPD]],[[ CEL]],[[ B-ALL]]
 
|[[PDE4DIP-PDGFRB]]
 
|[[PDE4DIP-PDGFRB]]
 
|-
 
|-
Line 42: Line 42:  
|-
 
|-
 
|[[t(1;14)(q21;q32)]]
 
|[[t(1;14)(q21;q32)]]
−
|[[B-ALL]],[[ NHL]]
+
|[[B-ALL]],[[NHL]]
 
|[[IGH-BCL9]],[[IGH-FCGR2B]],[[IGH-FCRL4]],[[IGH-MUC1]]
 
|[[IGH-BCL9]],[[IGH-FCGR2B]],[[IGH-FCRL4]],[[IGH-MUC1]]
 
|-
 
|-
Line 58: Line 58:  
|-
 
|-
 
|[[t(2;5)(p23;q35)]]
 
|[[t(2;5)(p23;q35)]]
−
|[[ALCL]],[[ NHL]]
+
|[[ALCL]],[[NHL]]
 
|[[NPM1-ALK]]
 
|[[NPM1-ALK]]
 
|-
 
|-
 
|[[t(2;8)(p12;q24.1)]]
 
|[[t(2;8)(p12;q24.1)]]
−
|[[BL]],[[ B-ALL]],[[ NHL ]]
+
|[[BL]],[[ B-ALL]],[[NHL]]
 
|[[MYC]]
 
|[[MYC]]
 
|-
 
|-
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|
 
|
 
|-
 
|-
−
|[[Translocation t(3;3)(q21;q26.2) and Inversion inv(3)(q21q26.2)|t(3;3)(q21;q26.2) ]]
+
|[[Translocation t(3;3)(q21;q26.2) and Inversion inv(3)(q21q26.2)|t(3;3)(q21;q26.2)]]
 
|[[MDS]],[[AML]]
 
|[[MDS]],[[AML]]
 
|[[RPN1-MECOM(EVI1)]]
 
|[[RPN1-MECOM(EVI1)]]
Line 98: Line 98:  
|-
 
|-
 
|[[t(4;5;5)(q23;q31;q33)]]
 
|[[t(4;5;5)(q23;q31;q33)]]
−
|[[chronic basophilic leukemia]]
+
|[[Chronic Basophilic Leukemia]]
 
|[[PRKG2-PDGFRB]]
 
|[[PRKG2-PDGFRB]]
 
|-
 
|-
Line 114: Line 114:  
|-
 
|-
 
|[[t(5;12)(q33;q24)]]
 
|[[t(5;12)(q33;q24)]]
−
|[[MPD with eosinophilia  ]]
+
|[[MPD]]
 
|[[GIT2-PDGFRB]]
 
|[[GIT2-PDGFRB]]
 
|-
 
|-
 
|[[t(5;12)(q33;p13)]]
 
|[[t(5;12)(q33;p13)]]
−
|[[CMML]],[[ MDS]],[[ MPD]]
+
|[[CMML]],[[MDS]],[[MPD]]
 
|[[ETV6(TEL)-PDGFRB]]
 
|[[ETV6(TEL)-PDGFRB]]
 
|-
 
|-
 
|[[t(5;14)(q33;q24)]]
 
|[[t(5;14)(q33;q24)]]
−
|[[MPD]],[[ atypical MPD]]
+
|[[MPD]],[[MPD]]
 
|[[NIN-PDGFRB]]
 
|[[NIN-PDGFRB]]
 
|-
 
|-
Line 130: Line 130:  
|-
 
|-
 
|[[t(5;15)(q33;q22)]]
 
|[[t(5;15)(q33;q22)]]
−
|[[CMML atypical MPD]]
+
|[[CMML]],[[MPD]]
 
|[[TP53BP1-PDGFRB]]
 
|[[TP53BP1-PDGFRB]]
 
|-
 
|-
Line 142: Line 142:  
|-
 
|-
 
|[[der(5;17)(p10;q10)]]
 
|[[der(5;17)(p10;q10)]]
−
|[[MDS]],[[ AML]]
+
|[[MDS]],[[AML]]
 
|[[NPM1(NPM)-RARA]]
 
|[[NPM1(NPM)-RARA]]
 
|-
 
|-
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|-
 
|-
 
|[[t(5;17)(q33;p13)]]
 
|[[t(5;17)(q33;p13)]]
−
|[[CMML]],[[ atypical MPD]]
+
|[[CMML]],[[MPD]]
 
|[[RABEP1-PDGFRB ]]
 
|[[RABEP1-PDGFRB ]]
 
|-
 
|-
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|-
 
|-
 
|[[t(6;11)(q27;q23) ]]
 
|[[t(6;11)(q27;q23) ]]
−
|[[AML]],[[ t-AML]],[[ T-ALL]]
+
|[[AML]],[[ t-AML]],[[T-ALL]]
 
|[[KMT2A-MLLT4]]
 
|[[KMT2A-MLLT4]]
 
|-
 
|-
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|[[IGH-MYC]]
 
|[[IGH-MYC]]
 
|-
 
|-
−
|[[t(8;16)(p11.2;p13.3) A]]
+
|[[t(8;16)(p11.2;p13.3)]]
 
|[[AML]],[[t-MDS]]
 
|[[AML]],[[t-MDS]]
 
|[[KAT6A(MYST3)-CREBBP(CBP)]]
 
|[[KAT6A(MYST3)-CREBBP(CBP)]]
 
|-
 
|-
 
|[[t(8;21)(q22;q22) A ]]
 
|[[t(8;21)(q22;q22) A ]]
−
|[[AML M2 mostly]],[[ rarely M1]],[[ M4]]
+
|[[AML]]
 
|[[RUNX1(AML)-RUNX1T1(ETO)]]
 
|[[RUNX1(AML)-RUNX1T1(ETO)]]
 
|-
 
|-
 
|[[t(8;22)(q24.1;q11.2) ]]
 
|[[t(8;22)(q24.1;q11.2) ]]
−
|[[BL]],[[ B-ALL]],[[ NHL]],[[ MM]]
+
|[[BL]],[[ B-ALL]],[[NHL]],[[ MM]]
 
|[[IGL-MYC]]
 
|[[IGL-MYC]]
 
|-
 
|-
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|-
 
|-
 
|[[t(9;14)(p13;q32)]]
 
|[[t(9;14)(p13;q32)]]
−
|[[MM]],[[CLL]],[[DLBCL]],[[ FL]],[[MCL splenic MZL]]
+
|[[MM]],[[CLL]],[[DLBCL]],[[FL]],[[MCL splenic MZL]]
 
|[[PAX5-IGH]]
 
|[[PAX5-IGH]]
 
|-
 
|-
 
|[[t(9;22)(q34;q11.2)]]
 
|[[t(9;22)(q34;q11.2)]]
−
|[[CML]],[[ B-ALL]],[[ T-ALL]]
+
|[[CML]],[[ B-ALL]],[[T-ALL]]
 
|[[ABL1(ABL)-BCR]]
 
|[[ABL1(ABL)-BCR]]
 
|-
 
|-
 
|[[t(11;14)(q13;q32)]]
 
|[[t(11;14)(q13;q32)]]
 
|[[MCL]],[[ MM]]
 
|[[MCL]],[[ MM]]
−
|[[CCND1(BCL1)- IGH]]
+
|[[IGH-CCND1]]
 
|-
 
|-
 
|[[t(11;14)(q23;q32)]]
 
|[[t(11;14)(q23;q32)]]
−
|[[t-AML]]
+
|[[AML]]
 
|[[KMT2A-KIAA0284]]
 
|[[KMT2A-KIAA0284]]
 
|-
 
|-
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|'''GENES'''
 
|'''GENES'''
 
|-
 
|-
−
|[[inv(3)(q21q26.2) ]]
+
|[[Translocation t(3;3)(q21;q26.2) and Inversion inv(3)(q21q26.2)|inv(3)(q21q26.2)]]
 
|[[MDS]],[[ AML]]
 
|[[MDS]],[[ AML]]
 
|[[RPN1-MECOM(EVI1)]]
 
|[[RPN1-MECOM(EVI1)]]
Line 356: Line 356:  
|-
 
|-
 
|[[i(11)(q10) ]]
 
|[[i(11)(q10) ]]
−
|[[AML M2]],[[AML M4]],[[ MDS]]
+
|[[AML]],[[AML]],[[ MDS]]
 
|
 
|
 
|-
 
|-
 
|[[i(17)(q10)]]
 
|[[i(17)(q10)]]
−
|[[MDS]],[[ MPD]],[[ AML]],[[ CML]],[[ B-ALL]],[[ CLL]],[[ Hodgkin and NHL]]
+
|[[MDS]],[[ MPD]],[[ AML]],[[ CML]],[[ B-ALL]],[[CLL]],[[ Hodgkin and NHL]]
 
|
 
|
 
|-
 
|-
 
|[[i(21)(q10)]]
 
|[[i(21)(q10)]]
−
|[[B-ALL]],[[ MDS]],[[ NHL]],[[ AML]],[[ CMML]]
+
|[[B-ALL]],[[ MDS]],[[ NHL]],[[AML]],[[ CMML]]
 
|
 
|
 
|-
 
|-
 
|[[idic(X)(q13)]]
 
|[[idic(X)(q13)]]
−
|[[AML M1]],[[ M2]],[[ M4]],[[ MDS]],[[ RARS]]
+
|[[AML]],[[MDS]],[[RARS]]
 
|[[XIST]]
 
|[[XIST]]
 
|}
 
|}
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|[[t(X;14) and t(Y;14)]]
 
|[[t(X;14) and t(Y;14)]]
 
|[[B-ALL]]
 
|[[B-ALL]]
−
|[[IGH-CRLF2]]
+
|[[T(X;14) and t(Y;14)|IGH-CRLF2]]
 
|-
 
|-
 
|[[t(5;14)(q35;q32)]]
 
|[[t(5;14)(q35;q32)]]
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|
 
|
 
|-
 
|-
−
|[[del(20)(q11.2q13.1)
+
|[[del(20)(q11.2q13.1)]]
 +
|
 +
|
 +
|-
 
|[[del(20)(q11.2q13.3)]]
 
|[[del(20)(q11.2q13.3)]]
 
|[[AML]],[[MDS]],[[MPD]]
 
|[[AML]],[[MDS]],[[MPD]]
 +
|
 
|-
 
|-
 
|[[ider(20)(p11.1)del(20)(q11.2q13.3)]]
 
|[[ider(20)(p11.1)del(20)(q11.2q13.3)]]
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|-
 
|-
 
|[[+15]]
 
|[[+15]]
−
|Age related when sole anomaly or with -Y
+
|[[Age Related]] when sole anomaly or with [[-Y]]
 
|-
 
|-
 
|[[+19]]
 
|[[+19]]
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|-
 
|-
 
|[[-Y ]]
 
|[[-Y ]]
−
|age related when sole anomaly
+
|[[Age Related]] when sole anomaly
    
|}
 
|}
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