Difference between revisions of "IGH Rearrangements"
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| + | [[Category:Translocations in B-ALL]] | ||
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Immunoglobulin locus rearrangements occur in tumors arising from the B-cell lineage [[B-ALL|ALL]], [[Lymphoma]] and [[Multiple Myeloma]]. | Immunoglobulin locus rearrangements occur in tumors arising from the B-cell lineage [[B-ALL|ALL]], [[Lymphoma]] and [[Multiple Myeloma]]. | ||
IGH/K/L partner genes are numerous and include: | IGH/K/L partner genes are numerous and include: | ||
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*FGFR3 | *FGFR3 | ||
*CEBPA | *CEBPA | ||
| + | *[[DUX4]] | ||
*BCL11A | *BCL11A | ||
*IRF4 | *IRF4 | ||
| Line 25: | Line 28: | ||
*BCL7A | *BCL7A | ||
*MYC | *MYC | ||
| − | *CRLF2 | + | *[[CRLF2]] |
*BCL8 | *BCL8 | ||
*[[IGH-EPOR|EPOR]] | *[[IGH-EPOR|EPOR]] | ||
Latest revision as of 12:05, 11 August 2016
Immunoglobulin locus rearrangements occur in tumors arising from the B-cell lineage ALL, Lymphoma and Multiple Myeloma.
IGH/K/L partner genes are numerous and include:
- BCL11B
- BACH2
- CCND1
- BCL2
- BANK1
- CCND3
- CCND2
- BCL10
- FGFR3
- CEBPA
- DUX4
- BCL11A
- IRF4
- CEBPB
- BCL2
- MAF
- CEBPD
- BCL3
- MAFB
- CEBPE
- BCL6
- MMSET
- CEBPG
- BCL7A
- MYC
- CRLF2
- BCL8
- EPOR
- CBAFA2T3
- HOXA
- CCND1
- ID4
- CCND2
- IGF2BP1
- CCNE1
- IL3
- CD44
- LCK
- CDK6
- LMO1
- CND3
- LMO2
- FCGR2A
- LYL1
- FCGR2B
- MYC
- FOXP1
- NOTCH1
- GPR34
- OLIG2
- IRF4
- TAL1
- IRF8
- TAL2
- IRTA1
- TCL1
- LHX2
- TLX1
- MALT1
- TLX3
- MUC1
- MYC
- NFKB2
- PAFAH1A2
- PAX5
- RCK
- SPIB
- ZPP36L1