Difference between revisions of "Collecting duct carcinoma"
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Positive: [[vimentin]], [[CK7]], [[CA-IX]], [[E-cadherin]], [[EMA]], [[PAX8]], [[PAX2]], [[CD117]], [[CD10]]. | Positive: [[vimentin]], [[CK7]], [[CA-IX]], [[E-cadherin]], [[EMA]], [[PAX8]], [[PAX2]], [[CD117]], [[CD10]]. | ||
| − | Negative: [[RCC]], [[AMACR]]. | + | Negative: [[RCC]], [[AMACR]], [[CD117]], [[CD10]], [[PAX2]]. |
== Genomic Gain/Loss/LOH == | == Genomic Gain/Loss/LOH == | ||
Revision as of 09:40, 5 August 2016
Contributors
Daynna Wolff PhD FACMG Yajuan Liu, PhD Rajyasree Emmadi, MD Banumathy Gowrishankar, PhD Jane Houldsworth, PhD
Tumor Type
Renal Cell Carcinoma
Tumor Classification
Collecting Duct Carcinoma
Description
Collecting Duct Carcinoma is a rare tumor in renal medulla from the distal collecting (Bellini's) ducts and accounts for <1% of renal epithelial tumors (Diaz JI, Mora LB, Hakam A. The Mainz Classification of Renal Cell Tumors. Cancer Control. 1999 Nov;6(6):571-579).
IHC Markers
Positive: vimentin, CK7, CA-IX, E-cadherin, EMA, PAX8, PAX2, CD117, CD10.
Negative: RCC, AMACR, CD117, CD10, PAX2.
Genomic Gain/Loss/LOH
| Chromosome | Gain/Loss/Amp | Region |
|---|---|---|
| 1 | Loss | Chr1 |
| 6 | Loss | Chr6 |
| 8 | Loss | 8p |
| 13 | Loss | 13q |
| 14 | Loss | 14q |
| 15 | Loss | 15q |
| 22 | Loss | Chr22 |
Rearrangements
Unknown
Mutations (SNV/INDEL)
From Cosmic Mutated in >20%
Mutated in 10-20%
Mutated in 5-10%
Mutated in 2-5%
mtDNA
Epigenomics (methylation)
Main Pathways Involved
Oncogenic signalling pathway
Diagnosis
Prognosis
Therapeutics
Familial Forms
Links
References
1. Crotty TB, Lawrence KM, Moertel CA, Bartelt DH Jr, Batts KP, Dewald GW, Farrow GM, Jenkins RB. Cytogenetic analysis of six renal oncocytomas and a chromophobe cell renal carcinoma. Evidence that -Y, -1 may be a characteristic anomaly in renal oncocytomas. Cancer Genet Cytogenet. 1992 Jul 1;61(1):61-6.
2. Antonelli A, Portesi E, Cozzoli A, Zanotelli T, Tardanico R, Balzarini P, Grigolato PG, Cosciani Cunico S. The collecting duct carcinoma of the kidney: a cytogenetical study. Eur Urol. 2003 Jun;43(6):680-5.