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HAEM5:ALK-positive anaplastic large cell lymphoma (view source)
Revision as of 10:13, 28 June 2024
, Friday at 10:13→Individual Region Genomic Gain / Loss / LOH
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|'''Laboratory Findings'''
|'''Laboratory Findings'''
|Noncontributory
|Noncontributory
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|Positive (universal) - Cellular location of ALK staining varies depending on ALK translocation partner. In the most common t(2;5), most cases show both cytoplasmic and nuclear||ALK
|Positive (universal) - Cellular location of ALK staining varies depending on ALK translocation partner. In the most common t(2;5), most cases show both cytoplasmic and nuclear||ALK
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|Positive (subset) ||EMA
|Positive (subset)||EMA
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|Negative - >75% of cases are CD3-negative||CD3
|Negative - >75% of cases are CD3-negative||CD3
|Granzyme B
|Granzyme B
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|Positive
|Positive
|Perforin
|Perforin
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|Variably positive
|Variably positive
|CD45
|CD45
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|t(2;5)(p23;q35)||3' ''ALK'' / 5' ''NPM1''<ref name=":20" />||''NPM1::ALK'' fusion protein||84%<ref name=":0" />
|t(2;5)(p23;q35)||3' ''ALK'' / 5' ''NPM1''<ref name=":20" />||''NPM1::ALK'' fusion protein||84%<ref name=":0" />
|No
|No
|No
|No
|Yes
|Yes
|2q
|2q
|Gain
|Gain
|EXAMPLE
|Chr 2:29,192,774-29,921,586
|EXAMPLE
|EXAMPLE
chr7
chr7
|Yes
|No
|Yes
|Yes
|No
|No