Line 1: |
Line 1: |
− | {{DISPLAYTITLE:Follicular lymphoma}}
| |
− |
| |
| [[HAEM5:Table_of_Contents|Haematolymphoid Tumours (5th ed.)]] | | [[HAEM5:Table_of_Contents|Haematolymphoid Tumours (5th ed.)]] |
| | | |
Line 76: |
Line 74: |
| | | |
| Put your text here and fill in the table <span style="color:#0070C0">(''Instruction: Can include references in the table'') </span> | | Put your text here and fill in the table <span style="color:#0070C0">(''Instruction: Can include references in the table'') </span> |
− | {| class="wikitable"
| |
− | |'''Signs and Symptoms'''
| |
− | |EXAMPLE Asymptomatic (incidental finding on complete blood counts)
| |
| | | |
− | EXAMPLE B-symptoms (weight loss, fever, night sweats)
| + | *FL commonly presents as painless lymphadenopathy<ref name=":12" /> |
− | | + | *May wax and wane over years before diagnosis |
− | EXAMPLE Fatigue
| + | *Majority of cases have widespread involvement at diagnosis<ref name=":12" /> |
− | | + | *Bone marrow involvement in 40-70% of cases at diagnosis |
− | EXAMPLE Lymphadenopathy (uncommon)
| + | *May not require treatment depending staging and other parameters. |
− | |-
| |
− | |'''Laboratory Findings'''
| |
− | |EXAMPLE Cytopenias
| |
− | | |
− | EXAMPLE Lymphocytosis (low level)
| |
− | |}
| |
| | | |
| | | |
Line 96: |
Line 85: |
| | | |
| | | |
− | *FL commonly presents as painless lymphadenopathy<ref name=":1" />
| |
− | *May wax and wane over years before diagnosis
| |
− | *Majority of cases have widespread involvement at diagnosis<ref name=":1" />
| |
− | *Bone marrow involvement in 40-70% of cases at diagnosis
| |
− | *May not require treatment depending staging and other parameters.
| |
| | | |
| | | |
Line 130: |
Line 114: |
| | | |
| | | |
− | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}[1, 2, 3, 4]</blockquote>
| |
| ==Immunophenotype== | | ==Immunophenotype== |
| | | |
| | | |
− | Typical FL has CD10+, BL2+. Atypical FL subgroups CD10- and/or BCL2 - all FL are STMN+ - useful differentiator between atypical FL and MZL [9]
| + | Typically, FL is CD10+, BL2+. Atypical FL subgroups CD10- and/or BCL2 - all FL are STMN+ - useful differentiator between atypical FL and MZL [9] |
| | | |
| {| class="wikitable sortable" | | {| class="wikitable sortable" |
Line 150: |
Line 133: |
| | | |
| | | |
− | <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}[1, 9, 10]</blockquote>
| |
| ==Chromosomal Rearrangements (Gene Fusions)== | | ==Chromosomal Rearrangements (Gene Fusions)== |
| | | |
− | Put your text here and fill in the table
| + | <br /> |
| | | |
| {| class="wikitable sortable" | | {| class="wikitable sortable" |
Line 163: |
Line 145: |
| !Notes | | !Notes |
| |- | | |- |
− | |EXAMPLE t(9;22)(q34;q11.2)||EXAMPLE 3'ABL1 / 5'BCR||EXAMPLE der(22)||EXAMPLE 20% (COSMIC) | + | |t(14;18)(q32;q21)||5' IGH / 3' BCL2||der(18)||80%~90% |
− | EXAMPLE 30% (add reference)
| + | |No |
− | |Yes | + | |No |
| |No | | |No |
− | |Yes | + | |Rarely, BCL2 rearrangement may also be observed with IGK at 2p11.2 or IGL at 22q11.22. Additional info and example karyotypes can be found here. |
− | |EXAMPLE
| |
− | | |
− | The t(9;22) is diagnostic of CML in the appropriate morphology and clinical context (add reference). This fusion is responsive to targeted therapy such as Imatinib (Gleevec) (add reference).
| |
| |} | | |} |
| | | |
Line 408: |
Line 387: |
| | | |
| ==Additional Information== | | ==Additional Information== |
− | Progenetix.org Follicular Lymphoma CNV plot: <nowiki>https://progenetix.org/subsets/list?filters=NCIT:C3209&datasetIds=progenetix</nowiki>
| |
− |
| |
| Precursor B cells typically mature in the marrow, where they may become mature naïve B cells or may apoptose. Following antigen exposure, mature B cells may become short lived plasma cells, or may enter the germinal center and undergo somatic hypermutation and heavy chain class switching. | | Precursor B cells typically mature in the marrow, where they may become mature naïve B cells or may apoptose. Following antigen exposure, mature B cells may become short lived plasma cells, or may enter the germinal center and undergo somatic hypermutation and heavy chain class switching. |
| | | |
Line 419: |
Line 396: |
| | | |
| [[HAEM5:Duodenal-type follicular lymphoma]] | | [[HAEM5:Duodenal-type follicular lymphoma]] |
− |
| |
− | [Https://progenetix.org/subsets/list%3Ffilters%3DNCIT:C3209%26datasetIds%3Dprogenetix Progenetix.org Follicular Lymphoma CNV plot] your links here (use "Link" icon at top of page)
| |
| | | |
| ==References== | | ==References== |