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HAEM5:Primary cutaneous CD4-positive small or medium T-cell lymphoproliferative disorder (view source)
Revision as of 13:03, 11 June 2024
, 11 June→Clinical Features
{| class="wikitable"
{| class="wikitable"
|'''Signs and Symptoms'''
|'''Signs and Symptoms'''
|<span class="blue-text">EXAMPLE:</span> Asymptomatic (incidental finding on complete blood counts)
|Asymptomatic
Slow growing
<span class="blue-text">EXAMPLE:</span> Lymphadenopathy (uncommon)
Solitary skin nodule/papule/plaque<ref name=":1" /><ref name=":0" />
|-
|-
|'''Laboratory Findings'''
|'''Laboratory Findings'''
|<span class="blue-text">EXAMPLE:</span> Cytopenias
|N/A
|}
|}
==Sites of Involvement==
==Sites of Involvement==
Skin, commonly involving head and neck region and upper body. <ref>{{Cite journal|last=Surmanowicz|first=Philip|last2=Doherty|first2=Sean|last3=Sivanand|first3=Arunima|last4=Parvinnejad|first4=Nikoo|last5=Deschenes|first5=Jean|last6=Schneider|first6=Michelle|last7=Hardin|first7=Jori|last8=Gniadecki|first8=Robert|date=2020-12-16|title=The Clinical Spectrum of Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferative Disorder: An Updated Systematic Literature Review and Case Series|url=https://doi.org/10.1159/000511473|journal=Dermatology|volume=237|issue=4|pages=618–628|doi=10.1159/000511473|issn=1018-8665}}</ref>
Skin, commonly involving head and neck region and upper body. <ref name=":1">{{Cite journal|last=Surmanowicz|first=Philip|last2=Doherty|first2=Sean|last3=Sivanand|first3=Arunima|last4=Parvinnejad|first4=Nikoo|last5=Deschenes|first5=Jean|last6=Schneider|first6=Michelle|last7=Hardin|first7=Jori|last8=Gniadecki|first8=Robert|date=2020-12-16|title=The Clinical Spectrum of Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferative Disorder: An Updated Systematic Literature Review and Case Series|url=https://doi.org/10.1159/000511473|journal=Dermatology|volume=237|issue=4|pages=618–628|doi=10.1159/000511473|issn=1018-8665}}</ref>
==Morphologic Features==
==Morphologic Features==
<br />
* Dense dermal lymphoid infiltrate, often with nodular or diffuse pattern
* Tends to extend to subcutaneous tissue
* Lack significant epidermotropism
* Predominantly small/medium-size T-cells with pleomorphism
* Low number of large lymphocytes allow (<30%)
* Often mixed background of CD8+ T-cells, B-cells plasma cells, histiocytes, +/-multinucleated giant cells<br />
==Immunophenotype==
==Immunophenotype==
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