17
edits
Changes
mLine 1:
Line 1: − {{DISPLAYTITLE:Follicular lymphoma}} − Line 76:
Line 74: − {| class="wikitable" − |'''Signs and Symptoms''' − |EXAMPLE Asymptomatic (incidental finding on complete blood counts) − EXAMPLE B-symptoms (weight loss, fever, night sweats)+ − + − EXAMPLE Fatigue+ − + − EXAMPLE Lymphadenopathy (uncommon)+ − |- − |'''Laboratory Findings''' − |EXAMPLE Cytopenias − − EXAMPLE Lymphocytosis (low level) − |} Line 96:
Line 85: − *FL commonly presents as painless lymphadenopathy<ref name=":1" /> − *May wax and wane over years before diagnosis − *Majority of cases have widespread involvement at diagnosis<ref name=":1" /> − *Bone marrow involvement in 40-70% of cases at diagnosis − *May not require treatment depending staging and other parameters. Line 130:
Line 114: − <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}[1, 2, 3, 4]</blockquote> − Typical FL has CD10+, BL2+. Atypical FL subgroups CD10- and/or BCL2 - all FL are STMN+ - useful differentiator between atypical FL and MZL [9]+ Line 150:
Line 133: − <blockquote class="blockedit">{{Box-round|title=Unassigned References|The following referenees were placed in the header. Please place them into the appropriate locations in the text.}}[1, 9, 10]</blockquote> − Put your text here and fill in the table+ Line 163:
Line 145: − + − EXAMPLE 30% (add reference)+ − + − + − |EXAMPLE − − The t(9;22) is diagnostic of CML in the appropriate morphology and clinical context (add reference). This fusion is responsive to targeted therapy such as Imatinib (Gleevec) (add reference). Line 408:
Line 387: − Progenetix.org Follicular Lymphoma CNV plot: <nowiki>https://progenetix.org/subsets/list?filters=NCIT:C3209&datasetIds=progenetix</nowiki> − Line 419:
Line 396: − − [Https://progenetix.org/subsets/list%3Ffilters%3DNCIT:C3209%26datasetIds%3Dprogenetix Progenetix.org Follicular Lymphoma CNV plot] your links here (use "Link" icon at top of page)
→Chromosomal Rearrangements (Gene Fusions)
[[HAEM5:Table_of_Contents|Haematolymphoid Tumours (5th ed.)]]
[[HAEM5:Table_of_Contents|Haematolymphoid Tumours (5th ed.)]]
Put your text here and fill in the table <span style="color:#0070C0">(''Instruction: Can include references in the table'') </span>
Put your text here and fill in the table <span style="color:#0070C0">(''Instruction: Can include references in the table'') </span>
*FL commonly presents as painless lymphadenopathy<ref name=":12" />
*May wax and wane over years before diagnosis
*Majority of cases have widespread involvement at diagnosis<ref name=":12" />
*Bone marrow involvement in 40-70% of cases at diagnosis
*May not require treatment depending staging and other parameters.
==Immunophenotype==
==Immunophenotype==
Typically, FL is CD10+, BL2+. Atypical FL subgroups CD10- and/or BCL2 - all FL are STMN+ - useful differentiator between atypical FL and MZL [9]
{| class="wikitable sortable"
{| class="wikitable sortable"
==Chromosomal Rearrangements (Gene Fusions)==
==Chromosomal Rearrangements (Gene Fusions)==
<br />
{| class="wikitable sortable"
{| class="wikitable sortable"
!Notes
!Notes
|-
|-
|EXAMPLE t(9;22)(q34;q11.2)||EXAMPLE 3'ABL1 / 5'BCR||EXAMPLE der(22)||EXAMPLE 20% (COSMIC)
|t(14;18)(q32;q21)||5' IGH / 3' BCL2||der(18)||80%~90%
|No
|Yes
|No
|No
|No
|Yes
|Rarely, BCL2 rearrangement may also be observed with IGK at 2p11.2 or IGL at 22q11.22. Additional info and example karyotypes can be found here.
|}
|}
==Additional Information==
==Additional Information==
Precursor B cells typically mature in the marrow, where they may become mature naïve B cells or may apoptose. Following antigen exposure, mature B cells may become short lived plasma cells, or may enter the germinal center and undergo somatic hypermutation and heavy chain class switching.
Precursor B cells typically mature in the marrow, where they may become mature naïve B cells or may apoptose. Following antigen exposure, mature B cells may become short lived plasma cells, or may enter the germinal center and undergo somatic hypermutation and heavy chain class switching.
[[HAEM5:Duodenal-type follicular lymphoma]]
[[HAEM5:Duodenal-type follicular lymphoma]]
==References==
==References==