View source for Large cell / anaplastic medulloblastoma


==Primary Author(s)*==

__TOC__

==Cancer Category/Type==

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==Cancer Sub-Classification / Subtype==

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==Definition / Description of Disease==

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==Synonyms / Terminology==

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==Epidemiology / Prevalence==

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==Clinical Features==

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==Sites of Involvement==

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==Morphologic Features==

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==Immunophenotype==

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{| class="wikitable sortable"
|-
! Finding   !! Marker
|-
|Positive (universal) || EXAMPLE CD1
|-
|Positive (subset) || EXAMPLE CD2
|-
|Negative (universal) || EXAMPLE CD3
|-
|Negative (subset) || EXAMPLE CD4
|}

==Chromosomal Rearrangements (Gene Fusions)==

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{| class="wikitable sortable"
|-
! Chromosomal Rearrangement !! Genes in Fusion (5’ or 3’ Segments) !! Pathogenic Derivative !! Prevalence
|-
|EXAMPLE t(9;22)(q34;q11.2) || EXAMPLE 3'ABL1 / 5'BCR || EXAMPLE der(22) || EXAMPLE 5%
|-
|EXAMPLE t(8;21)(q22;q22) || EXAMPLE 5'RUNX1 / 3'RUNXT1 || EXAMPLE der(8) || EXAMPLE 5%
|}		
			
==Characteristic Chromosomal Aberrations / Patterns==

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==Genomic Gain/Loss/LOH==

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{| class="wikitable sortable"
|-
! Chromosome Number !! Gain/Loss/Amp/LOH !! Region
|-
|EXAMPLE 8 || EXAMPLE Gain || EXAMPLE chr8:0-1000000
|-
|EXAMPLE 7 || EXAMPLE Loss || EXAMPLE chr7:0-1000000
|}	
		
==Gene Mutations (SNV/INDEL)==

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{| class="wikitable sortable"
|-
! Gene !! Mutation !! Oncogene/Tumor Suppressor/Other !! Presumed Mechanism (LOF/GOF/Other; Driver/Passenger) !! Prevalence (COSMIC/TCGA/Other)
|-
| EXAMPLE TP53 || EXAMPLE R273H || EXAMPLE Tumor Suppressor || EXAMPLE LOF || EXAMPLE 20%
|}	
		
===Other Mutations===
{| class="wikitable sortable"
|-
! Type !! Gene/Region/Other
|-
| Concomitant Mutations || EXAMPLE IDH1 R123H
|-
| Secondary Mutations || EXAMPLE Trisomy 7
|-
|Mutually Exclusive || EXAMPLE EGFR Amplification
|}

==Epigenomics (Methylation)==

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==Genes and Main Pathways Involved==

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==Diagnostic Testing Methods==

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==Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications)==

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==Familial Forms==

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==Other Information==

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==Links==

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==References==

=== EXAMPLE Book ===
#Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4thedition.Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.

=== EXAMPLE Journal Article ===
#Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.

== Notes ==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.