View source for Diffuse large B-cell lymphoma


==Primary Author(s)*==

__TOC__

==Cancer Category/Type==

Breast

==Cancer Sub-Classification / Subtype==

Put your text here

==Definition / Description of Disease==

Put your text here

==Synonyms / Terminology==

Put your text here

==Epidemiology / Prevalence==

Put your text here

==Clinical Features==

Put your text here

==Sites of Involvement==

Put your text here

==Morphologic Features==

Put your text here

==Immunophenotype==

Put your text here and/or fill in the table

{| class="wikitable sortable"
|-
! Finding   !! Marker
|-
|Positive (universal) || EXAMPLE CD1
|-
|Positive (subset) || EXAMPLE CD2
|-
|Negative (universal) || EXAMPLE CD3
|-
|Negative (subset) || EXAMPLE CD4
|}

==Chromosomal Rearrangements (Gene Fusions)==

Put your text here and/or fill in the table

{| class="wikitable sortable"
|-
! Chromosomal Rearrangement !! Genes in Fusion (5’ or 3’ Segments) !! Pathogenic Derivative !! Prevalence
|-
|EXAMPLE t(9;22)(q34;q11.2) || EXAMPLE 3'ABL1 / 5'BCR || EXAMPLE der(22) || EXAMPLE 5%
|-
|EXAMPLE t(8;21)(q22;q22) || EXAMPLE 5'RUNX1 / 3'RUNXT1 || EXAMPLE der(8) || EXAMPLE 5%
|}		
			
==Characteristic Chromosomal Aberrations / Patterns==

Put your text here

==Genomic Gain/Loss/LOH==

Put your text here and/or fill in the table

{| class="wikitable sortable"
|-
! Chromosome Number !! Gain/Loss/Amp/LOH !! Region
|-
|EXAMPLE 8 || EXAMPLE Gain || EXAMPLE chr8:0-1000000
|-
|EXAMPLE 7 || EXAMPLE Loss || EXAMPLE chr7:0-1000000
|}	
		
==Gene Mutations (SNV/INDEL)==

Put your text here and/or fill in the tables

{| class="wikitable sortable"
|-
! Gene !! Mutation !! Oncogene/Tumor Suppressor/Other !! Presumed Mechanism (LOF/GOF/Other; Driver/Passenger) !! Prevalence (COSMIC/TCGA/Other)
|-
| EXAMPLE TP53 || EXAMPLE R273H || EXAMPLE Tumor Suppressor || EXAMPLE LOF || EXAMPLE 20%
|}	
		
===Other Mutations===
{| class="wikitable sortable"
|-
! Type !! Gene/Region/Other
|-
| Concomitant Mutations || EXAMPLE IDH1 R123H
|-
| Secondary Mutations || EXAMPLE Trisomy 7
|-
|Mutually Exclusive || EXAMPLE EGFR Amplification
|}

==Epigenomics (Methylation)==

Put your text here

==Genes and Main Pathways Involved==

Put your text here

==Diagnostic Testing Methods==

Put your text here

==Clinical Significance (Diagnosis, Prognosis and Therapeutic Implications)==

Put your text here

==Familial Forms==

Put your text here

==Other Information==

Put your text here

==Links==

Put your links here

==References==

=== EXAMPLE Book ===
#Arber DA, et al., (2008). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4thedition.Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW, Editors. IARC Press: Lyon, France, p117-118.

=== EXAMPLE Journal Article ===
#Li Y, et al., (2001). Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet 28:220-221, PMID 11431691.

== Notes ==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.