View source for HAEM4:Splenic B-cell Lymphoma/Leukemia, Unclassifiable

==Primary Author(s)*==

* Snehal Patel, MD, PhD
__TOC__

==Graphical Data Links==

* N/A

==General Disease Overview / Description of Cancer Category==

Splenic B-cell lymphoma/leukemia, Unclassifiable (SBLL-U) includes primary splenic lymphomas that cannot be better classified into other [[HAEM4:Mature B-Cell Neoplasms|mature B-cell neoplasms]] and are overall rare, accounting for <1% of lymphomas.  Two entities in this category, [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli|hairy cell leukemia variant]] (HCL-v) and [[HAEM5:Splenic diffuse red pulp small B-cell lymphoma|splenic diffuse red pulp small B-cell lymphoma]] (SDRPL) may represent distinct entities and are designated as provisional entities in the 2017 WHO.  Recent molecular evidence suggests that they are distinct from each other and from [[HAEM5:Splenic marginal zone lymphoma|splenic marginal zone lymphoma]] and [[HAEM5:Hairy cell leukaemia|hairy cell leukemia]], which which the have overlapping clinical, morphologic, and immunophenotypic features.  Primary splenic lymphomas that cannot be classified as HCL-v or SDRPL should be classified as splenic B-cell lymphoma/leukemia, Unclassifiable.

==WHO Classification Pages (Includes Links to Content)==

* [[HAEM5:Splenic diffuse red pulp small B-cell lymphoma]]
* [[HAEM5:Splenic B-cell lymphoma/leukaemia with prominent nucleoli]]

==Other Related Pages (Includes Links to Content)==

Differential diagnosis:  other small B-cell lymphomas with cytoplasmic projections and significant splenic involvement

* [[HAEM5:Splenic marginal zone lymphoma]]
* [[HAEM5:Hairy cell leukaemia]]

==Additional Information==

* N/A

==References==

<references />

===EXAMPLE Book===

#Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p129-171.

==Notes==
<nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page.  If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage).  Additional global feedback or concerns are also welcome.

<nowiki>*</nowiki>The hierarchical tumour classification structure displayed on this page is reproduced from the [https://tumourclassification.iarc.who.int/welcome/ WHO Classification of Tumours] with permission from the copyright holder, ©International Agency for Research on Cancer.