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...ollaborative project to document and describe chromosome and other genomic abnormalities in cancer. This resource is supported by the [http://www.cancergenomics.org ...es V|V]]''' | '''[[:Category:Diseases W|W]]''' | '''[[:Category:Diseases X|X]]''' | '''[[:Category:Diseases Y|Y]]''' | '''[[:Category:Diseases Z|Z]]'''

== Structural == * Structural Abnormalities

...in >50 chromosome (usually <66), typically without translocations or other structural alterations.   ...tology|volume=99|issue=1|pages=93–100|doi=10.1046/j.1365-2141.1997.3493163.x|issn=0007-1048|pmid=9359508}}</ref> <ref>{{Cite journal|last=Reismüller|fi

...et al., (2017). B-Lymphoblastic leukaemia/lymphoma with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic a ...the general population. Additionally, patients with a constitutional ring chromosome 21, r(21), may potentially be predisposed to iAMP21 ALL.<ref name=":0" />

|Fusions involving ''MYB'' with other gene partners or complex structural abnormalities associated with ''MYB'' gene fusion generate more complex karyotypes. Loss ...ns involving ''MYBL1'' with other gene partners or more complex structural abnormalities associated with ''MYBL1'' gene fusion generate more complex karyotypes. Oth

...st2=K.|last3=Comair|first3=Y. G.|date=1995-07|title=Cortical architectural abnormalities and MIB1 immunoreactivity in gangliogliomas: a study of 60 patients with in ...st5=L.|last6=Feng|first6=X.-Y.|last7=Dai|first7=S.-H.|last8=Wang|first8=W.-X.|last9=Sun|first9=Q.-R.|date=2008-01|title=Intracranial ganglioglioma: clin

...mphoblastic leukemias. The majority of cases (>80%) fall within the 44-45 chromosome range. However, beyond this, there are three main groups, that although ra ...edscape Article, Drugs & Diseases, Hematology.</ref>. Hypodiploid ALL with chromosome numbers less than 44 is associated with poor prognosis.

...gression, see the table below for the more commonly implicated cytogenetic abnormalities. !Chromosome Number!!Gain/Loss/Amp/LOH!!Region

...ac|date=2012-09-13|title=Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas|url=http ...rst9=Kip|date=2012|title=Genome-wide analysis reveals recurrent structural abnormalities of TP63 and other p53-related genes in peripheral T-cell lymphomas|url=http

...Options in Oncology|volume=20|issue=1|pages=9|doi=10.1007/s11864-019-0605-x|issn=1534-6277|pmid=30715612}}</ref>. ...et age and shorter median survival<ref name=":5" />. ''RUNX2'', located on chromosome 6p21, is strongly expressed in pDCs and BPDCN cells. The t(6,8) generates m

...noglobulin deposition disease (Randall type). Relationship with structural abnormalities of immunoglobulin chains|url=https://linkinghub.elsevier.com/retrieve/pii/S ...age=en|volume=125|issue=6|pages=681–700|doi=10.1111/j.1365-2141.2004.04970.x|issn=0007-1048}}</ref>

...r C.|last5=Eberhart|first5=Charles G.|date=2008-09|title=Frequent gains at chromosome 7q34 involving BRAF in pilocytic astrocytoma|url=https://pubmed.ncbi.nlm.ni ...gal|first8=S.|last9=Jauch|first9=A.|date=2007-02-15|title=Frequent loss of chromosome 9, homozygous CDKN2A/p14(ARF)/CDKN2B deletion and low TSC1 mRNA expression

...Cytology|volume=21|issue=3|pages=186–190|doi=10.1111/j.1365-2303.2009.0641.x|issn=1365-2303|pmid=19416310}}</ref> |+Table 4: Cytogenetic abnormalities on clinical course and prognosis in multiple myeloma (adapted from Rajan an