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Recurrent Genomic Alterations in Pediatric and Adult Central Nervous System Tumors Detected by Chromosomal Microarray (view source)
Revision as of 12:14, 16 April 2021
, 12:14, 16 April 2021updated citation
'''Amplification:''' GLI2 (TP53-mutant tumors), IGF1R, PPM1D, MYCN (TP53-mutant tumors), YAP1, MIR17/92, MDM4
'''Amplification:''' GLI2 (TP53-mutant tumors), IGF1R, PPM1D, MYCN (TP53-mutant tumors), YAP1, MIR17/92, MDM4
|Common in infants, rare in children, most common type of medulloblastoma in adults; Desmoplastic (or nodular) histology common; TP53 wild-type usually correlate with extensive nodularity or desmoplastic histology; TP53-mutant tumors correlate with metastatic disease
|Common in infants, rare in children, most common type of medulloblastoma in adults; Desmoplastic (or nodular) histology common; TP53 wild-type usually correlate with extensive nodularity or desmoplastic histology; TP53-mutant tumors correlate with metastatic disease
|PMID:24651015; PMID:21681522; <ref name=":28" />PMID:22832581 <ref name=":29" />PMID:24493713; PMID:24077351; <ref name=":30" />PMID:22134537; <ref name=":31" />PMID:22358457 <ref name=":32" />PMID:25043047; <ref name=":33" />PMID:22820256; <ref name=":34" />PMID:26976201 <ref name=":34" />PMID:20823417; <ref name=":35" />PMID:22265402; <ref name=":36" />PMCID:3889646 <ref name=":37" />PMID:16567768; <ref name=":38" />PMID:20940197
|<ref>{{Cite journal|last=Kool|first=Marcel|last2=Jones|first2=David T. W.|last3=Jäger|first3=Natalie|last4=Northcott|first4=Paul A.|last5=Pugh|first5=Trevor J.|last6=Hovestadt|first6=Volker|last7=Piro|first7=Rosario M.|last8=Esparza|first8=L. Adriana|last9=Markant|first9=Shirley L.|date=2014-03-17|title=Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition|url=https://pubmed.ncbi.nlm.nih.gov/24651015|journal=Cancer Cell|volume=25|issue=3|pages=393–405|doi=10.1016/j.ccr.2014.02.004|issn=1878-3686|pmc=4493053|pmid=24651015}}</ref>PMID:24651015; <ref>{{Cite journal|last=Northcott|first=Paul A.|last2=Hielscher|first2=Thomas|last3=Dubuc|first3=Adrian|last4=Mack|first4=Stephen|last5=Shih|first5=David|last6=Remke|first6=Marc|last7=Al-Halabi|first7=Hani|last8=Albrecht|first8=Steffen|last9=Jabado|first9=Nada|date=2011-08|title=Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct|url=https://pubmed.ncbi.nlm.nih.gov/21681522|journal=Acta Neuropathologica|volume=122|issue=2|pages=231–240|doi=10.1007/s00401-011-0846-7|issn=1432-0533|pmc=4538327|pmid=21681522}}</ref>PMID:21681522; <ref name=":28" />PMID:22832581 <ref name=":29" />PMID:24493713; <ref>{{Cite journal|last=Gajjar|first=Amar|last2=Stewart|first2=Clinton F.|last3=Ellison|first3=David W.|last4=Kaste|first4=Sue|last5=Kun|first5=Larry E.|last6=Packer|first6=Roger J.|last7=Goldman|first7=Stewart|last8=Chintagumpala|first8=Murali|last9=Wallace|first9=Dana|date=2013-11-15|title=Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study|url=https://pubmed.ncbi.nlm.nih.gov/24077351|journal=Clinical Cancer Research: An Official Journal of the American Association for Cancer Research|volume=19|issue=22|pages=6305–6312|doi=10.1158/1078-0432.CCR-13-1425|issn=1557-3265|pmc=3856244|pmid=24077351}}</ref>PMID:24077351; <ref name=":30" />PMID:22134537; <ref name=":31" />PMID:22358457 <ref name=":32" />PMID:25043047; <ref name=":33" />PMID:22820256; <ref name=":34" />PMID:26976201 <ref name=":34" />PMID:20823417; <ref name=":35" />PMID:22265402; <ref name=":36" />PMCID:3889646 <ref name=":37" />PMID:16567768; <ref name=":38" />PMID:20940197
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