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| ==Myeloproliferative Neoplasms (MPN)== | | ==Myeloproliferative Neoplasms (MPN)== |
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| *[[Chronic Myeloid Leukemia (CML), BCR-ABL1 Positive]] | | *[[Chronic Myeloid Leukemia (CML), BCR-ABL1 Positive]] |
| *[[Chronic Neutrophilic Leukemia (CNL)]] | | *[[Chronic Neutrophilic Leukemia (CNL)]] |
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| *[[Myeloproliferative Neoplasm (MPN), Unclassifiable]] | | *[[Myeloproliferative Neoplasm (MPN), Unclassifiable]] |
| *[[Some new stuff]] | | *[[Some new stuff]] |
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| + | '''Primary Author(s)*''' |
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| + | '''Cancer Category/Type''' |
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| + | Put your text here |
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| + | '''Cancer Sub-Classification/Subtype''' |
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| + | '''Definition/Description of Disease''' |
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| + | '''Synonyms/Terminology''' |
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| + | '''Epidemiology/Prevalence''' |
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| + | '''Clinical Features''' |
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| + | Put your text here and fill in the table |
| + | <br /> |
| + | {| class="wikitable" |
| + | |'''Signs and Symptoms''' |
| + | |EXAMPLE Asymptomatic (incidental finding on complete blood counts) |
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| + | EXAMPLE B-symptoms (weight loss, fever, night sweats) |
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| + | EXAMPLE Fatigue |
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| + | EXAMPLE Lymphadenopathy (uncommon) |
| + | |- |
| + | |'''Laboratory Findings''' |
| + | |EXAMPLE Cytopenias |
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| + | EXAMPLE Lymphocytosis (low level) |
| + | |} |
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| + | '''Sites of Involvement''' |
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| + | '''Morphologic Features''' |
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| + | '''Immunophenotype''' |
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| + | Put your text here and fill in the table |
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| + | {| class="wikitable" |
| + | |'''Positive (universal)''' |
| + | |EXAMPLE CD1 |
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| + | |'''Positive (subset)''' |
| + | |EXAMPLE CD2 |
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| + | |'''Negative (universal)''' |
| + | |EXAMPLE CD3 |
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| + | |'''Negative (subset)''' |
| + | |EXAMPLE CD4 |
| + | |} |
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| + | '''Chromosomal Rearrangements (Gene Fusions)''' |
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| + | Put your text here and fill in the table |
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| + | {| class="wikitable" |
| + | |'''Chromosomal Rearrangement''' |
| + | |'''Genes in Fusion''' |
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| + | '''(5’ or 3’ Segments)''' |
| + | |'''Pathogenic Derivative''' |
| + | |'''Prevalence''' |
| + | |'''Diagnostic Significance (Yes, No or Unknown)''' |
| + | |'''Prognostic Significance (Yes, No or Unknown)''' |
| + | |'''Therapeutic Significance (Yes, No or Unknown)''' |
| + | |'''Notes''' |
| + | |- |
| + | |EXAMPLE t(9;22)(q34;q11.2) |
| + | |EXAMPLE 3'ABL1 / 5'BCR |
| + | |EXAMPLE der(22) |
| + | |EXAMPLE 20% (COSMIC) |
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| + | EXAMPLE 30% (add reference) |
| + | |Yes |
| + | |No |
| + | |Yes |
| + | |EXAMPLE |
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| + | The t(9;22) is diagnostic of CML in the appropriate morphology and clinical context (add reference). This fusion is responsive to targeted therapy such as Imatinib (Gleevec) (add reference). |
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| + | |} |
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| + | '''Individual Region Genomic Gain/Loss/LOH''' |
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| + | Put your text here and fill in the table |
| + | <br /> |
| + | {| class="wikitable" |
| + | |'''Chr #''' |
| + | |'''Gain/Loss/Amp/LOH''' |
| + | |'''Minimal Region Genomic Coordinates [Genome Build]''' |
| + | |'''Minimal Region Cytoband''' |
| + | |'''Diagnostic Significance (Yes, No or Unknown)''' |
| + | |'''Prognostic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Therapeutic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Notes''' |
| + | |- |
| + | |EXAMPLE |
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| + | 7 |
| + | |EXAMPLE Loss |
| + | |EXAMPLE |
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| + | chr7:1- 159,335,973 [hg38] |
| + | |EXAMPLE |
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| + | chr7 |
| + | |Yes |
| + | |Yes |
| + | |No |
| + | |EXAMPLE |
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| + | Presence of monosomy 7 (or 7q deletion) is sufficient for a diagnosis of AML with MDS-related changes when there is ≥20% blasts and no prior therapy (add reference). Monosomy 7/7q deletion is associated with a poor prognosis in AML (add reference). |
| + | |- |
| + | |EXAMPLE |
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| + | 8 |
| + | |EXAMPLE Gain |
| + | |EXAMPLE |
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| + | chr8:1-145,138,636 [hg38] |
| + | |EXAMPLE |
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| + | chr8 |
| + | |No |
| + | |No |
| + | |No |
| + | |EXAMPLE |
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| + | Common recurrent secondary finding for t(8;21) (add reference). |
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| + | '''Characteristic Chromosomal Patterns''' |
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| + | Put your text here |
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| + | {| class="wikitable" |
| + | |'''Chromosomal Pattern''' |
| + | |'''Diagnostic Significance (Yes, No or Unknown)''' |
| + | |'''Prognostic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Therapeutic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Notes''' |
| + | |- |
| + | |EXAMPLE |
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| + | Co-deletion of 1p and 18q |
| + | |Yes |
| + | |No |
| + | |No |
| + | |EXAMPLE: |
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| + | See chromosomal rearrangements table as this pattern is due to an unbalanced derivative translocation associated with oligodendroglioma (add reference). |
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| + | |} |
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| + | '''Gene Mutations (SNV/INDEL)''' |
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| + | Put your text here and fill in the table |
| + | {| class="wikitable" |
| + | |'''Gene; Genetic Alteration''' |
| + | |'''Presumed Mechanism (Tumor Suppressor Gene (TSG)/Oncogene/Other)''' |
| + | |'''Prevalence (COSMIC/ TCGA/Other)''' |
| + | |'''Concomitant Mutations''' |
| + | |'''Mutually Exclusive Mutations''' |
| + | |'''Diagnostic Significance (Yes, No or Unknown)''' |
| + | |'''Prognostic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Therapeutic Significance''' |
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| + | '''(Yes, No or Unknown)''' |
| + | |'''Notes''' |
| + | |- |
| + | |EXAMPLE: TP53; Variable LOF mutations |
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| + | EXAMPLE: |
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| + | EGFR; Exon 20 mutations |
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| + | EXAMPLE: BRAF; Activating mutations |
| + | |EXAMPLE: TSG |
| + | |EXAMPLE: 20% (COSMIC) |
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| + | EXAMPLE: 30% (add Reference) |
| + | |EXAMPLE: IDH1 R123H |
| + | |EXAMPLE: EGFR amplification |
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| + | |EXAMPLE: Excludes hairy cell leukemia (HCL) (add reference). |
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| + | |} |
| + | Note: A more extensive list of mutations can be found in cBioportal (<nowiki>https://www.cbioportal.org/</nowiki>), COSMIC (<nowiki>https://cancer.sanger.ac.uk/cosmic</nowiki>), ICGC (<nowiki>https://dcc.icgc.org/</nowiki>) and/or other databases. When applicable, gene-specific pages within the CCGA site directly link to pertinent external content. |
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| + | '''Epigenomic Alterations''' |
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| + | Put your text here |
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| + | '''Genes and Main Pathways Involved''' |
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| + | Put your text here and fill in the table |
| + | {| class="wikitable" |
| + | |'''Gene; Genetic Alteration''' |
| + | |'''Pathway''' |
| + | |'''Pathophysiologic Outcome''' |
| + | |- |
| + | |EXAMPLE: BRAF and MAP2K1; Activating mutations |
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| + | EXAMPLE: CDKN2A; Inactivating mutations |
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| + | EXAMPLE: KMT2C and ARID1A; Inactivating mutations |
| + | |EXAMPLE: MAPK signaling |
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| + | EXAMPLE: Cell cycle regulation |
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| + | EXAMPLE: Histone modification, chromatin remodeling |
| + | |EXAMPLE: Increased cell growth and proliferation |
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| + | EXAMPLE: Unregulated cell division |
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| + | EXAMPLE: Abnormal gene expression program |
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| + | |} |
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| + | '''Genetic Diagnostic Testing Methods''' |
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| + | '''Familial Forms''' |
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| + | '''Additional Information''' |
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| + | '''Links''' |
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| + | Put your text placeholder here (use "Link" icon at top of page) |
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| + | '''References''' |
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| + | (use "Cite" icon at top of page) |
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| + | BOOK EXAMPLE: Arber DA, et al., (2017). Acute myeloid leukaemia with recurrent genetic abnormalities, in World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues, Revised 4th edition. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, and Siebert R, Editors. IARC Press: Lyon, France, p130-149. |
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| + | '''Notes''' |
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| + | <nowiki>*</nowiki>Primary authors will typically be those that initially create and complete the content of a page. If a subsequent user modifies the content and feels the effort put forth is of high enough significance to warrant listing in the authorship section, please contact the CCGA coordinators (contact information provided on the homepage). Additional global feedback or concerns are also welcome. |